Medical use of amentoflavone in treatment of chicken necrotic enteritis

Abstract

The invention relates to the medical use of amentoflavone in treatment of chicken necrotic enteritis. The clostridium perfringen sliding motion inhibition test, the biofilm formation inhibition test,the chicken necrotic enteritis model treatment test, and the histopathological section observation and intestinal flora analysis test confirm that the amentoflavone has protective effects against chicken necrotic enteritis caused by clostridium perfringen infection. Due to the abuse of traditional antibiotics and the continuous enhancement of bacterial drug resistance, the amentoflavone has the characteristics of high cure rate, no drug resistance and drug residues. Therefore, the amentoflavone is used for treating chicken necrotic enteritis, which can increase the selectivity of use of drugs,and has an important significance for the development of new drugs.

Description

technical field [0001] The invention discloses the medical use of the biflavonoids of spiky chinensis in treating chicken necrotic enteritis, relates to the application of the biflavones of spiky spiky in the preparation of medicines for treating chicken necrotic enteritis, and belongs to the technical field of medicine. Background technique [0002] Clostridium perfringens is an anaerobic Gram-positive bacillus, which widely exists in soil, water, food, human and animal feces, livestock feed and animal intestines in nature, and is the normal intestinal flora of humans and animals , an opportunistic pathogen. At present, according to the different exotoxins it secretes, it is divided into 5 serotypes, A-E, and poultry are mainly infected with type A and type C Clostridium perfringens, especially type A. After Clostridium perfringens infects poultry, it mainly causes necrotic enteritis, and its symptoms are manifested as listlessness, loose feathers, loss of appetite or wast...

AI Technical Summary

Problems solved by technology

In recent years, a large number of literatures have reported on the pharmacological activity of afenoflavones, but up to now, there is no relevant research on the use of afenoflavones in the treatment of chicken necrotic enteritis caused by Clostridium perfringens at home and abroad.

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