Magnesium alloy and macromolecular wire hybrid composite sticking patch and application thereof

A magnesium alloy and polymer technology, which is applied in the field of magnesium alloy and polymer wire blended composite patch, can solve the problems of non-degradation, increased wounds, partial degradation, etc., and achieves the effect of stable pH and avoiding long-term complications.

Active Publication Date: 2018-11-23
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the above-mentioned patches are mostly made of polymer materials and cannot be degraded or partially degraded
The implantation of these traditional artificial materials in the body will increase the chance of wound infection. Postoperative infection is the biggest complication, and it must be removed by secondary surgery after infection.

Method used

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  • Magnesium alloy and macromolecular wire hybrid composite sticking patch and application thereof
  • Magnesium alloy and macromolecular wire hybrid composite sticking patch and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0027] The preparation method of the magnesium alloy wire in the present invention is: turning the cylindrical blank for wire extrusion of a certain height; performing hot extrusion on the cylindrical blank for wire extrusion at a certain temperature to obtain a wire blank with a diameter of φ1-2mm ;Thin wires with different wire diameters can be obtained by multi-pass drawing, rolling deformation and auxiliary heat treatment on the wire blank. The preparation method of the polymer filament is as follows: the absorbable polymer (polylactic acid, polycaprolactone, collagen) is melted and extruded to prepare the polymer filament.

[0028] The morphology of the biodegradable mixed weaving composite patch prepared in the present invention can be as follows figure 1 As shown, it can also be figure 2 shown.

Embodiment 1

[0030] 1) The Mg-Zn-Zr alloy thin wire with a circular cross-section and a diameter of 0.05 mm prepared by the above method and the polylactic acid polymer wire with a diameter of 0.05 mm are braided into a thin rope on a braiding machine, and then used The rope is woven into a net, and the size of the net can be cut arbitrarily.

[0031] 2) After electrolytic polishing, cleaning, drying, packaging and sterilization, it is ready for use.

[0032] The thickness of the final product is 0.1mm, and the area of ​​a single mesh is 0.1mm 2 .

Embodiment 2

[0034] 1) Mg-Zn-Gd-based alloy filaments with an elliptical cross-section, a major axis of 0.05 mm and a minor axis of 0.04 mm and a circular cross-section with a diameter of 0.1 mm were prepared by the above method. The polycaprolactone polymer thread is woven into a net on the knitting machine, which can be cut arbitrarily.

[0035] 2) After electropolishing and cleaning.

[0036] 3) Degradable coating treatment.

[0037] 4) Dry, package, and sterilize before use.

[0038] The thickness of the final product is 0.2mm, and the area of ​​a single mesh is 1mm 2 .

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Abstract

The invention provides a magnesium alloy and macromolecular wire hybrid composite sticking patch and application thereof. The composite sticking patch is formed through mixed weaving of a magnesium alloy wire material and a degradable macromolecular wire material, and provided with a net structure. The magnesium alloy ad macromolecular wire hybrid composite sticking patch has the advantages that 1, the sticking patch is completely degradable, and absorbed and metabolized by human body in the recovering process from disease, the sticking patch has the good supporting effect in the early implanting stage, and is completely degraded, absorbed and replaced by autologous tissue after tissue recovering is completed in the late stage, and long-term complications caused by a traditional material can be avoided; and 2, by adjusting the size, the appearance and the weaving method of the whole wire material, the composite sticking patches in different types can be obtained, and the sticking patches have different strength and different degradation and absorption time, and can be adaptive to different illness states.

Description

technical field [0001] The invention relates to a composite patch made of magnesium alloy and polymer wire and its application, which belongs to the technical field of medical consumables. Background technique [0002] Mesh has a wide range of clinical applications in disease treatment and plastic surgery. On the one hand, many disease treatments require the use of tissue repair patches. For example, it is very difficult to repair large tissue defects in the chest wall, abdominal wall, etc., and patches are often used in clinical surgical treatment. Secondly, a hernia means that an organ leaves its original location and enters another location through a weak point or defect or a hole in the human body. Mesh is also needed in the process of surgical treatment. Thirdly, female pelvic floor dysfunction is a gynecological disease with stress urinary incontinence, pelvic organ prolapse and chronic pelvic pain as the main symptoms. Compared with hysterectomy, it improves the sa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/32A61L27/18A61L27/04A61L27/50A61L27/58A61L31/10A61L31/08A61L31/06A61L31/02A61L31/14
CPCA61L27/047A61L27/18A61L27/32A61L27/34A61L27/50A61L27/58A61L31/022A61L31/06A61L31/086A61L31/10A61L31/14A61L31/148A61L2430/00C08L67/04
Inventor 黄华袁广银
Owner SHANGHAI JIAO TONG UNIV
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