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Centrifugal microfluidic device

A microfluidic device and chassis technology, applied in the field of biomedical engineering, can solve problems such as low production efficiency and complex device structure, and achieve the effects of low cost, low operation requirements, simple and efficient multi-form packaging

Pending Publication Date: 2018-11-27
UNIV OF SCI & TECH OF CHINA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In view of this, the object of the present invention is to provide a centrifugal microfluidic device, the structural design of which can effectively solve the problems of complex device structure and low production efficiency when encapsulating cells or drugs

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Embodiment Construction

[0038] The object of the present invention is to provide a centrifugal microfluidic device, the structural design of which can effectively solve the problems of complex device structure and low production efficiency when encapsulating cells or drugs.

[0039] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0040] In the description of the present invention, it should be understood that the orientation or positional relationship indicated by the terms "upper", "lower", "front", "rear", "left" and "right" are based o...

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Abstract

The invention discloses a centrifugal microfluidic device. The centrifugal microfluidic device comprises a bottom disc, multiple nozzles and a driving part. Multiple collecting cavities distributed inthe circumferential direction are formed in the bottom disc. The nozzles can be arranged on the bottom disc and distributed in the circumferential direction. An outlet of any nozzle is communicated with the interior of one collecting cavity, the distances between the outlets of the nozzles and the bottom walls of the collecting cavities are larger than zero, and the nozzles are located on the sides, close to the center of the bottom disc, of the collecting cavities. The driving part can drive the bottom disc to rotate. By means of the centrifugal microfluidic device, when the driving part drives the bottom disc to rotate, a sodium alginate solution and cell suspension liquid in the nozzles enter the collecting cavities respectively, then multiple hydrogel carriers can be formed, and the production efficiency of the hydrogel carriers is greatly improved.

Description

technical field [0001] The invention relates to the technical field of biomedical engineering, in particular to a centrifugal microfluidic device. Background technique [0002] Micron-scale hydrogel capsules or fibers are commonly used as carriers for encapsulating cells and drugs in the field of biomedicine. Through microfluidics, electrostatic spraying and other technical means, stem cells or drugs can be encapsulated in these microcarriers, and then transplanted into the body for disease treatment or cell culture in vitro. [0003] Alginate hydrogel is a widely used encapsulation material, which has the advantages of low cost, good biocompatibility, and mild crosslinking conditions. Encapsulating cells into microcarriers made of alginate hydrogel can provide cells with a spatial structure similar to that in vivo, and better simulate cell proliferation and interaction. In addition, the loose and porous structure of hydrogel also ensures the material exchange between cell...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00B01J13/00C12M1/00
CPCB01J13/0052B01J13/0065C12M45/22B01L3/5027B01L3/502753B01L2200/12B01L2200/0647B01L2400/0409
Inventor 赵刚程跃白雪飞
Owner UNIV OF SCI & TECH OF CHINA
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