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Application of dihydroflavone derivative in herba penthori chinense in preparing drug for resisting liver cell steatosis

A technology of dihydroflavonoids and steatosis, applied in the field of medicine, can solve the problems of non-alcoholic fatty liver with less intervention effect

Inactive Publication Date: 2018-11-30
CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, there are few reports on the intervention effect of non-alcoholic fatty liver disease

Method used

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  • Application of dihydroflavone derivative in herba penthori chinense in preparing drug for resisting liver cell steatosis
  • Application of dihydroflavone derivative in herba penthori chinense in preparing drug for resisting liver cell steatosis
  • Application of dihydroflavone derivative in herba penthori chinense in preparing drug for resisting liver cell steatosis

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Embodiment Construction

[0041] The present invention will be described below through specific examples, but the present invention is not limited thereto.

[0042] The experimental methods used in the following examples are conventional methods unless otherwise specified; the reagents and biological materials used in the following examples can be obtained from commercial sources unless otherwise specified.

[0043] 1. Experimental materials

[0044] 1.1 Reagents

[0045] MCI GEL CHP / CHPMG resin (polystyrene-based reversed-phase resin), Mitsubishi Fine Chemicals; acetonitrile (chromatographically pure), American FISHER Reagent Company; 95% ethanol, Sinopharm Chemical Reagent Co., Ltd.; distilled water, Wahaha purified water; fetal calf Serum (FBS), DMEM high glucose medium, PBS solution (pH 7.4) and 0.25% trypsin containing EDTA, American Gibco Company; MTT, oleic acid (OA), palmitic acid (PA), bovine serum albumin (BSA) , Cell-grade dimethyl sulfoxide (DMSO), Sigma, USA; BCA protein content detection ...

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Abstract

The invention relates to an application of a dihydroflavone derivative in herba penthori chinense in preparing a drug for resisting liver cell steatosis. A structural formula of the dihydroflavone derivative is as shown in formulas I-1, I-2 or I-3. The invention researches an effect of three dihydroflavones in herba penthori chinense extract for resisting the liver cell steatosis. The herba penthori chinense extract is divided into five components by adopting an MCI column, three characteristic dihydroflavones in the component V are selected to obtain pinocembrin (PCB), pinocembrin -7-O-beta-D- glucoside (PCBG) and 5-methoxyl-pinocembrin-7-O-beta-d-glucoside (MPG), the free fatty acid is adopted to induce a HepG2 cell injury model to investigate the influence of the PCBG, PCB and MPG for cell activity, fat content, TC, TG, ALT, AST, MDA, SOD and GSH-Px. The result shows that the three characteristic dihydroflavones in the herba penthori chinense respectively have the activity for resisting the liver cell steatosis.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of dihydroflavone derivatives in C. chinensis in the preparation of drugs for resisting hepatocyte steatosis. Background technique [0002] In recent years, the global incidence of nonalcoholic fatty liver disease (NAFLD) has increased year by year. With the improvement of people's living standards and changes in diet structure, NAFLD has become one of the common chronic liver diseases in my country. The incidence rate in cities has reached 15%-25%. 10% of the patients develop into nonalcoholic steatohepatitis (NASH), nearly 30% of the patients develop into liver cirrhosis, and some patients even develop into liver cancer. At present, it is generally believed that NAFLD is a genetic-environment-metabolic-stress-related disease, which is closely related to obesity, diabetes, hyperlipidemia, metabolic syndrome and insulin resistance (insulin resistance, IR). The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K31/7048A61P1/16C07D311/40C07H17/07C07H1/08
CPCA61K31/352A61K31/7048A61K36/185A61P1/16C07D311/40C07H1/08C07H17/07
Inventor 吴霞郭未蔚
Owner CAPITAL UNIVERSITY OF MEDICAL SCIENCES
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