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Fufangteng extract and its preparation method and anti-HIV application

A technology of extract and Fufangteng, applied in the direction of food ingredients, applications, antiviral agents containing natural extracts, etc., can solve the problems of narrow antiviral spectrum and drug resistance

Active Publication Date: 2021-07-27
GUANGXI MEDICAL UNIVERSITY
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  • Abstract
  • Description
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Problems solved by technology

Recent studies have shown that specific HIV inhibitors usually have a narrow antiviral spectrum and are likely to lead to drug resistance

Method used

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  • Fufangteng extract and its preparation method and anti-HIV application
  • Fufangteng extract and its preparation method and anti-HIV application
  • Fufangteng extract and its preparation method and anti-HIV application

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Embodiment Construction

[0022] One, the preparation of fufangteng extract

[0023] Such as figure 1 Shown, the preparation of Fufangteng extract of the present invention is carried out according to the following steps:

[0024] (1) Take the stems and leaves of Fufangcane, dry them and pulverize them, use 95% ethanol solution to reflux and degrease through a Soxhlet extractor for 5 hours according to the ratio of material to liquid 1:20, and then put them into an oven for drying to obtain dry powder of Fufangcane stems and leaves;

[0025] (2) Take 50g of dried vine stem and leaf dry powder, dissolve it with ultrapure water at a material-to-liquid ratio of 1:60, ultrasonicate for 75 minutes at 80°C, filter under reduced pressure, combine the filtrates, and concentrate under reduced pressure to 150ml to obtain a dark brown concentrated liquid; place the concentrated liquid in a refrigerator at 4°C for overnight refrigeration, and centrifuge the concentrated liquid at 5000r / min the next day to obtain t...

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Abstract

The invention discloses a preparation method of fufangteng extract, in which 15% ethanol extraction parts are obtained. Utilizing the extract, the inventors used two virus infection systems to verify its anti-HIV activity. As a result, both the TZM-b1-HIV-IIIB system and the MT2-HIV-IIIB system showed good anti-HIV activity, and the highest concentration The relative cell viability is greater than 90%, and has a significant inhibitory effect on the replication of HIV‑1. Studies have shown that it can inhibit virus infection in a large concentration range without causing great toxicity to cells, so the extract is the effective part of Fufangteng anti-HIV traditional Chinese medicine. The present invention makes full use of the abundant resources of Fufangteng, a commonly used folk medicine of Zhuang Yao people in Guangxi, provides a more powerful theoretical basis for in-depth research on its medicinal value and clinical significance in the future, and can be applied to the further development and application of anti-HIV drugs.

Description

technical field [0001] The invention belongs to the technical field of Fufangteng of Guangxi Zhuang medicine and Yao medicine, and in particular relates to an extract of Fufangteng and its preparation method and anti-HIV application. Background technique [0002] AIDS (Acquired immunodeficiency syndrome, AIDS) is an acquired immunodeficiency syndrome caused by human immunodeficiency virus (HIV) infection. Since the first AIDS case was discovered in 1983, AIDS is still a worldwide public health problem because no effective cure vaccine or drug has been developed yet. The AIDS epidemic in my country is also relatively severe. As of March 31, 2018, there were 789,617 surviving HIV / AIDS patients reported nationwide, 245,498 reported deaths, 460,551 surviving HIV infections, and 329,066 AIDS patients. [0003] HIV is an RNA virus belonging to the family Retroviridae and the genus Lentivirus. During HIV infection, HIV-1 outer membrane glycoprotein gp120 specifically binds to the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/37A61P31/18A23L33/105
CPCA23V2002/00A61K36/37A61K2236/333A61K2236/53A23L33/105A61P31/18A23V2200/30A23V2250/21
Inventor 梁浩蔡丹昭叶力蒋俊俊刘欣梁冰玉黄颉刚温奇龙周波覃凤翔梁娜
Owner GUANGXI MEDICAL UNIVERSITY
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