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Euonymus fortunei extract, and preparation method and anti-HIV application thereof

A technology of fufangteng and its extract, which is applied in the field of fufangteng extract and its preparation, and anti-HIV application, and can solve problems such as drug resistance and narrow antiviral spectrum

Active Publication Date: 2018-12-04
GUANGXI MEDICAL UNIVERSITY
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

Recent studies have shown that specific HIV inhibitors usually have a narrow antiviral spectrum and are likely to lead to drug resistance

Method used

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  • Euonymus fortunei extract, and preparation method and anti-HIV application thereof
  • Euonymus fortunei extract, and preparation method and anti-HIV application thereof
  • Euonymus fortunei extract, and preparation method and anti-HIV application thereof

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Embodiment Construction

[0022] One, the preparation of fufangteng extract

[0023] like figure 1 Shown, the preparation of Fufangteng extract of the present invention is carried out according to the following steps:

[0024] (1) Take the stems and leaves of Fufangcane, dry and pulverize them, use 95% ethanol solution to reflux and degrease through a Soxhlet extractor for 5 hours according to the ratio of material to liquid 1:20, and then put them into an oven for drying to obtain dry powder of Fufangcane stems and leaves;

[0025] (2) Take 50g of dried vine stem and leaf powder, dissolve it with ultrapure water at a material-to-liquid ratio of 1:60, ultrasonicate for 75 minutes at 80°C, filter under reduced pressure, combine the filtrates, and concentrate under reduced pressure to 150ml to obtain a dark brown concentrated liquid; place the concentrated liquid in a 4°C refrigerator for overnight refrigeration, and centrifuge the concentrated liquid at 5000r / min the next day to obtain the supernatant;...

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Abstract

The invention discloses a preparation method of Euonymus fortunei extract. The method is used to obtain a 15% ethanol extraction part. A result of verification of the anti-HIV activity of the extractby using two virus infection systems shows that a TZM-b1-HIV-IIIB system and an MT2-HIV-IIIB system have good anti-HIV activity, have a relative cell vitality at a highest concentration of above 90%,and have a significant inhibition effect on HIV-1 replication. Studies show that the extract can inhibit viral infection in a large concentration range without causing great toxicity to cells, so theextract is an anti-HIV traditional Chinese medicine effective part of the Euonymus fortunei. The abundant resources of the common folk medicine Euonymus fortunei of the Zhuang and Yao Nationality in Guangxi are fully used, a powerful theoretical foundation is laid for further researching the medicinal values and clinical significance of the Euonymus fortunei, and the extract can be applied to thefurther development and application of anti-HIV drugs.

Description

technical field [0001] The invention belongs to the technical field of Fufangteng of Guangxi Zhuang medicine and Yao medicine, and in particular relates to an extract of Fufangteng and its preparation method and anti-HIV application. Background technique [0002] AIDS (Acquired immunodeficiency syndrome, AIDS) is an acquired immunodeficiency syndrome caused by human immunodeficiency virus (HIV) infection. Since the first AIDS case was discovered in 1983, AIDS is still a worldwide public health problem because no effective cure vaccine or drug has been developed yet. The AIDS epidemic in my country is also relatively severe. As of March 31, 2018, there were 789,617 surviving HIV / AIDS patients reported nationwide, 245,498 reported deaths, 460,551 surviving HIV infections, and 329,066 AIDS patients. [0003] HIV is an RNA virus belonging to the family Retroviridae and the genus Lentivirus. During HIV infection, HIV-1 outer membrane glycoprotein gp120 specifically binds to the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/37A61P31/18A23L33/105
CPCA23V2002/00A61K36/37A61K2236/333A61K2236/53A23L33/105A61P31/18A23V2200/30A23V2250/21
Inventor 梁浩蔡丹昭叶力蒋俊俊刘欣梁冰玉黄颉刚温奇龙周波覃凤翔梁娜
Owner GUANGXI MEDICAL UNIVERSITY
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