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Bone peptide glucose injection

A technology for glucose injection and glucose, which is applied in the field of bone peptide glucose injection and its preparation, can solve the problems of affecting the safety of medicines, secondary pollution of medicines, generation of pyrogen reactions, etc., so as to reduce the possibility and convenience of medicine pollution. Clinical use, the effect of improving efficiency

Inactive Publication Date: 2018-12-04
郑永刚
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since peptide injections are usually infused intravenously in clinical use, they need to be temporarily dissolved in 200ml of 0.9% sodium chloride injection, which will easily cause secondary pollution of drugs and pyrogenic reactions during static injection. Affect the safety of drug use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0007] Osteopeptide glucose injection, take healthy fresh pig limb bones, add pure water to 1.2 kg / cm2 hot-pressed extraction for 1.5 hours, filter, add pure water to the bone residue and hot-press for 1 hour, filter, combine the filtrates twice, 0-5 Stand in a cold room at ℃ for 12 hours, remove the upper layer of fat, concentrate in vacuum below 70 ℃ to about 1 / 5 of the volume of the filtrate, add 95% ethanol until the final concentrated solution is 70% (v / v), precipitate and filter out impurity proteins to obtain clarification Liquid, vacuum concentrated below 60°C to about 1 / 4, add pure water to 1 / 2 of the total volume, dilute the ethanol-free concentrated solution with water to the total volume, adjust the pH to 4.0±0.1 with HCL, and filter with activated carbon at 100°C To obtain the filtrate, adjust the pH to 7.0-7.2 with NaOH, suction filter at 80°C with activated carbon, cool, and ultrafiltrate the ultrafiltration column with a molecular weight cut-off of 10,000, cool ...

Embodiment 2

[0009] Take healthy and fresh pork limb bones, add pure water to 1.2 kg / cm2 hot-pressed extraction for 1.5 hours, filter, add pure water to the bone residue and hot-press for 1 hour, filter, combine the filtrates twice, and stand in a cold room at 0-5°C for 12 hours , remove the upper layer of fat, concentrate in vacuum below 70°C to about 1 / 5 of the filtrate volume, add 95% ethanol until the final concentration is 70% (v / v), precipitate and filter out impurities to obtain a clear liquid, vacuum below 60°C Concentrate to about 1 / 4, add pure water to 1 / 2 of the total volume, dilute the ethanol-free concentrated solution with water to the total volume, adjust the pH to 4.0±0.1 with HCL, filter with activated carbon at 100°C to obtain the filtrate, adjust it with NaOH PH to 7.0-7.2, activated carbon suction filtration at 80°C, cooling, molecular weight cut-off 10000 ultrafiltration column ultrafiltration, cooling to obtain bone peptide raw material solution; weigh 5kg of glucose, ...

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PUM

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Abstract

The invention discloses a preparation technology for a bone peptide glucose injection. The injection is prepared from adding a certain proportion of glucose on the basis of a bone peptide raw materialliquid; the bone peptide raw material liquid can be prepared from performing hot pressing extraction, concentration, alcohol precipitation, acid-base precipitation and ultrafiltration on limb bones of pigs; and adding the glucose in proportion, and diluting the mixture with injection water so that the injection can be prepared. The injection consists of the bone peptide raw material liquid, the glucose and the injection water; and each 100 ml of the injection contains 50-100 mg of the bone peptide raw material liquid (by polypeptide) and 5 g of the glucose. Thus, a process that a bone peptideinjection is temporarily dissolved in a glucose solution during intravenous drip in the past can be simplified, convenient clinical use can be realized, efficiency can be enhanced, and the probability of drugs being polluted can be reduced; and the injection can be used for promoting fracture healing.

Description

technical field [0001] The invention relates to an osteopeptide glucose injection and a preparation process thereof. Background technique [0002] The main component of osteopeptide is small molecule polypeptide, which is a mixture of small peptides decomposed from collagen. During storage, it can self-polymerize to form larger molecules. With the extension of storage time, the precipitation of polymers increases, thereby producing antigens. Its polymerization increases with the increase of the concentration of peptides, which causes an increase in the incidence of allergic reactions in clinical applications, up to 0.1%. Generally, rashes, fever, and hypotension begin to appear after 5-6 days of medication. Since peptide injections are usually infused intravenously in clinical use, they need to be temporarily dissolved in 200ml of 0.9% sodium chloride injection, which will easily cause secondary pollution of drugs and pyrogenic reactions during static injection. Affect the ...

Claims

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Application Information

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IPC IPC(8): A61K38/01A61K9/08A61K47/26A61P19/08A61P19/10
CPCA61K38/014A61K9/0019A61K9/08A61K47/26
Inventor 郑永刚
Owner 郑永刚
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