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Equipment for preparing lipid nanospheres

A kind of equipment and water phase technology, which is applied in the field of equipment for preparing liposphere colostrum, can solve the problems of undisclosed colostrum storage equipment, inability to adapt to industrial production, separation of oil phase and water phase, etc., and improve equipment utilization efficiency , reduce surface oil slick phenomenon, reduce the effect of phase separation

Pending Publication Date: 2018-12-04
本溪恒康制药有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] CN101496787B discloses a preparation method of lipid microspheres, the preparation method involves the preparation of water phase and the preparation of colostrum, no storage equipment for colostrum is disclosed
The equipment disclosed in the above documents is relatively simple in the preparation of colostrum, and the stability of the prepared colostrum is poor, and the problem of phase separation between the oil phase and the water phase is prone to occur.
In addition, the emulsification head of the above-mentioned equipment is fixed to the middle and lower part of the tank body through the tank top, and there is a technical problem that the emulsification head runs idly during the emptying process, which cannot be adapted to the preparation of special emulsification systems such as microemulsions, nanoemulsions, and lipospheres. Industrial production

Method used

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  • Equipment for preparing lipid nanospheres
  • Equipment for preparing lipid nanospheres
  • Equipment for preparing lipid nanospheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] like figure 1 The described equipment for preparing lipid microsphere emulsion includes a water phase tank 1, an oil phase tank 2, a three-stage online disperser 3, a high-pressure homogenization device 4, and a storage tank 5. The water phase tank 1 and the oil phase tank 2 are connected to the inlet of the three-stage online disperser 3 through a connecting pipe, and the outlet of the three-stage online disperser is connected to the storage tank 5 through a connecting pipe, and the storage tank 5 is connected to the homogenizing equipment 4 . Valves are provided at the outlets of the water phase tank 1, the oil phase tank 2, the connecting pipe of the three-stage online disperser 3, and the storage tank 4. The valves on the connecting pipes of the water phase tank, the oil phase tank and the three-stage online disperser can adjust the mixing volume ratio of the water phase and the oil phase. The water phase tank and the oil phase tank are equipped with turbine agitat...

Embodiment 2

[0051] like figure 2 The described equipment for preparing lipid microsphere emulsion includes a water phase tank 1, an oil phase tank 2, a three-stage online disperser 3, and a homogenization device 4. The water phase tank 1 and the oil phase tank 2 are connected to the inlet of the three-stage online disperser 3 through a connecting pipe, the outlet of the three-stage online disperser is connected to the top of the water phase tank through a connecting pipe, and another outlet is set at the bottom of the water phase tank and passed through the connecting pipe Connected with homogenizing equipment 4. Valves are installed at the outlets of the water phase tank 1, oil phase tank 2, and connecting pipes of the third-stage online disperser 3. The valves on the connecting pipe of the disperser can adjust the flow rate to control the mixing volume ratio of the water phase and the oil phase. There are stirring devices to promote dissolution in both the water phase tank and the oi...

Embodiment 3

[0055] like image 3 In the described equipment for preparing lipid microsphere emulsion, on the basis of the equipment in Example 2, a connecting pipe is added between the bottom of the water phase tank 1 and the top of the oil phase tank, and the connecting pipe is provided with a valve.

[0056] image 3 The equipment completes the configuration of the water phase and the oil phase in the water phase tank 1 and the oil phase tank 2 respectively, by adjusting the valve on the connecting pipe between the water phase tank 2 and the three-stage online disperser 3, and the oil phase tank 2 and the three-stage online The valve on the connecting pipe of the disperser 3 allows the water phase and the oil phase to enter the three-stage online disperser 3 for shear emulsification according to the volume ratio of 5:1, and the sheared mixture flows into the water phase tank 1 through the connecting pipe. After the oil phase tank is emptied, close the valve on the connecting pipe betwe...

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Abstract

The invention provides equipment for preparing lipid nanospheres. The primary emulsion preparation part comprises a water phase tank, an oil phase tank and a multi-stage online dispersion machine; anda high-speed shear emulsification head is installed in the water phase tank. According to the equipment provided by the invention, combined emulsification is performed by the multi-stage online dispersing machine and the high-speed shear emulsification head in the equipment, so that stability of a primary emulsion is improved; the water phase tank in the equipment has the functions of water phasepreparation, emulsification and primary-emulsion final product temporary storage, and connection of the water phase tank and the top of the oil phase tank can realize cyclic shearing of a mixed phasein the multi-stage online dispersion machine while the oil phase tank is washed; and the equipment is simplified, reduces adhesion loss of the primary emulsion in the transfer process, and is suitable for industrialized production of the lipid nanospheres.

Description

technical field [0001] The invention relates to the field of chemical equipment, in particular to a device for preparing lipid microspheres, in particular to a device for preparing lipid microsphere colostrum. Background technique [0002] Lipid nanospheres (lipid nanospheres, LN) are based on vegetable oil, outsourced with phospholipid nanospheres, made of oil phase, emulsifier, and water phase, with a particle size in the range of 100-300nm, stable oil-in-water (O / W) dispersion system. The drug can be encapsulated in the oil phase and the phospholipid interface membrane. The drug-loading system requires that the drug has strong fat solubility, or that the encapsulated drug can be converted into an active substance in a rapid and timely manner after reaching the target site to exert its curative effect. Before the site, leakage release rarely occurs. The conventional preparation method is to dissolve the drug and (or) emulsifier in the water phase or the oil phase, heat ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/04B01F3/08
CPCB01J13/04B01F23/43
Inventor 刘长宏张震吴斌
Owner 本溪恒康制药有限公司
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