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A kind of traditional Chinese medicine composition for hand, foot and mouth disease

A technology of hand, foot and mouth disease and composition, applied in the field of traditional Chinese medicine

Active Publication Date: 2021-05-04
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently no specific treatment for the disease

Method used

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  • A kind of traditional Chinese medicine composition for hand, foot and mouth disease
  • A kind of traditional Chinese medicine composition for hand, foot and mouth disease
  • A kind of traditional Chinese medicine composition for hand, foot and mouth disease

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Effect test

Embodiment 1

[0076] The preparation of embodiment 1 Chinese medicine composition tablet

[0077] Raw material ratio: Houttuynia cordata: 700g, honeysuckle 700g, red peony 600g, mugwort leaves 360g, mint 360g

[0078] Step A: Weigh the Chinese medicinal materials according to the weight ratio of the raw materials, the honeysuckle is cleaned, the red peony is roughly crushed, the whole mint is crushed, and the Houttuynia cordata and Artemisia argyi are directly used for later use.

[0079] Step B: Flos Lonicerae is reflux extracted twice with 12 times the amount of 50% ethanol, each time for 0.5h, the extracts are combined and filtered, and the ethanol is recovered to obtain extract 1, the specific gravity is 1.20-1.30 (60-80°C), dried, and dried Cream powder 1, set aside.

[0080] Step C: Add 8 times of water, heat to 80°C, add Houttuynia cordata, mugwort leaves, and mint in turn, extract volatile oil for 5 hours, add red peony powder to the dregs, add 10 times of water, decoct twice, 1 ho...

Embodiment 2

[0083] The preparation of embodiment 2 Chinese medicine composition granules

[0084] Proportion of raw medicinal materials: Houttuynia cordata 750g, honeysuckle 750g, red peony root 450g, mugwort leaves 300g, mint 150g.

[0085] Step A: Weigh the Chinese medicinal materials according to the weight ratio of the raw materials, the honeysuckle is cleaned, the red peony is roughly crushed, the whole mint is crushed, and the Houttuynia cordata and Artemisia argyi are directly used for later use.

[0086] Step B: Flos Lonicerae is reflux extracted twice with 12 times the amount of 50% ethanol, each time for 0.5h, the extracts are combined and filtered, and the ethanol is recovered to obtain extract 1, the specific gravity is 1.20-1.30 (60-80°C), dried, and dried Cream powder 1, set aside.

[0087] Step C: Add 8 times of water, heat to 80°C, add Houttuynia cordata, mugwort leaves, and mint in turn, extract volatile oil for 5 hours, add red peony powder to the dregs, add 10 times of...

Embodiment 3

[0090] The preparation of embodiment 3 Chinese medicine composition gel

[0091] Proportion of raw medicinal materials: Houttuynia cordata 325g, honeysuckle 325g, red peony root 225g, mugwort leaves 150g, mint 75g.

[0092] Step A: Weigh the Chinese medicinal materials according to the weight ratio of the raw materials, the honeysuckle is cleaned, the red peony is roughly crushed, the whole mint is crushed, and the Houttuynia cordata and Artemisia argyi are directly used for later use.

[0093]Step B: Flos Lonicerae is reflux extracted twice with 12 times the amount of 50% ethanol, each time for 0.5h, the extracts are combined and filtered, the ethanol is recovered to obtain extract 1, the specific gravity is 1.20-1.30 (60-80°C), and thick extract 1 is obtained ,spare.

[0094] Step C: Add 8 times of water, heat to 80°C, add Houttuynia cordata, mugwort leaves, and mint in turn, extract volatile oil for 5 hours, add red peony powder to the dregs, add 10 times of water, decoct ...

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Abstract

The present invention proposes the application of a composition in preparing a medicine for hand, foot and mouth disease, characterized in that the composition is prepared from the following raw materials in parts by weight: 5-30 parts by weight of honeysuckle, Houttuynia cordata 5-30 parts by weight, 5-20 parts by weight of red peony, 5-15 parts by weight of argyi leaves, and 5-15 parts by weight of mint. It is proved by in vitro pharmacodynamics experiments that the composition or its preparation of the present invention has a significant effect in preventing and treating hand, foot and mouth disease, and its inhibitory effect on viruses is significantly stronger than that of ribavirin in both prevention and treatment. Moreover, the medicine of the invention has low cytotoxicity and better safety in clinical application.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating or preventing hand, foot and mouth. Background technique [0002] Hand-foot-mouth disease (HFMD) is a common infectious disease caused by enteroviruses. There are more than 20 types (types) of enteroviruses causing the disease. It manifests as mouth pain, anorexia, low-grade fever, small herpes and small ulcers on the hands, feet, mouth and other parts. Although most patients recover by themselves in about a week, some children still have complications such as myocarditis and pulmonary edema, and even The disease progressed rapidly and resulted in death. There is currently no effective treatment for this disease. [0003] The infection routes of HFMD include digestive tract, respiratory tract and contact transmission. Therefore, the transmission speed is fast in children and the incidence range is wid...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/78A61K9/16A61P31/14
CPCA61K9/1652A61K36/282A61K36/355A61K36/534A61K36/65A61K36/71A61K36/78A61K2236/331A61K2236/333A61K2236/53A61P31/14A61K2300/00
Inventor 肖伟闫明韦迎春刘秋王振中吴云连洁
Owner JIANGSU KANION PHARMA CO LTD