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Application of biotransformation bear gall powder for preparing antibacterial medicine

A technology for biotransformation and antibacterial drugs, applied in antibacterial drugs, pharmaceutical formulations, medical preparations containing active ingredients, etc.

Pending Publication Date: 2018-12-18
SHANGHAI KAIBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Even more serious is the long-term resistance of animal protection organizations at home and abroad to live bear bile harvesting, especially the recent "Guizhentang" incident that has once again aroused widespread concern from the international and domestic communities, which has greatly affected the production of domestic bear bile powder and the development of related industries. brought unprecedented resistance

Method used

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  • Application of biotransformation bear gall powder for preparing antibacterial medicine
  • Application of biotransformation bear gall powder for preparing antibacterial medicine
  • Application of biotransformation bear gall powder for preparing antibacterial medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The preparation of embodiment 1 biotransformation bear bile powder

[0019] According to the preparation method in the invention patent application 201410588581.5, the biotransformation bear bile powder was prepared. The raw material poultry gall used in the present invention can be (and not limited to) chicken gall, duck gall, goose gall, ox gall, rabbit gall, dog gall, sheep gall, etc. The poultry gall powder described in the present invention can be (and not limited to) poultry gall powder such as chicken gall powder, duck gall powder, goose gall powder, ox gall powder, rabbit gall powder, dog gall powder, sheep gall powder, etc. One or more mixtures of them. Preferably, the main components and mass percentages of poultry bile powder are as follows: cholic acid: 40-65%, amino acid: 4-9%, trace element: 0.5-1%; wherein, the total cholic acid contains TCDCA, The TCDCA accounts for 40-50% by mass of poultry bile powder. In addition to the above main ingredients, poul...

Embodiment 2

[0032] Embodiment 2 in vitro antibacterial experiment

[0033] 1. Materials and methods

[0034] 1.1 Test compound:

[0035] Biotransformation bear bile powder (ABBP, the biotransformation bear bile powder prepared in Example 1) was provided by Shanghai Kaibao Pharmaceutical.

[0036] 1.2 Test bacteria

[0037] The tested strains were clinically isolated strains collected by the Institute of Antibiotics of Huashan Hospital Affiliated to Fudan University, including 3 strains of Streptococcus pyogenes and 3 strains of Streptococcus pneumoniae.

[0038] 2. Results

[0039] The antibacterial effects of ABBP on the tested bacteria are shown in Table 1. According to the results in Table 1, ABBP has an antibacterial effect on Streptococcus bacteria, and the MIC range of ABBP is 0.25-1 mg / ml.

[0040] Table 1 In vitro antibacterial effect

[0041]

Embodiment 3

[0042] Embodiment 3 in vivo antibacterial experiment

[0043] 1. Materials

[0044] 1.1 Experimental animals

[0045] 1.1.1 Basic situation

[0046] (1) Animal strain: ICR mouse

[0047] (2) Age: 2-3 weeks old

[0048] (3) Gender: half male and half male

[0049] (4) Weight range: male: 17.4g-25.7g, female: 16.7g-23.8g.

[0050] (5) Source: Hunan Slack Jingda Experimental Animal Co., Ltd.

[0051] 1.1.2 Animal grouping method:

[0052] Negative control group (20 rats / group), model group (20 rats / group), low, middle and high dose groups of biotransformed bear bile powder (20 rats / group).

[0053] 1.2 Negative control substance and solvent

[0054] 1.2.1 Negative control substance:

[0055] 0.5% sodium carboxymethylcellulose (CMC-Na) (analytically pure), the specification is 500g / bottle, the batch number is 20150806, and the manufacturer is Tianjin Damao Chemical Reagent Factory.

[0056] 1.2.2 Preparation method:

[0057] (1) Preparation environment requirements: There...

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Abstract

The invention discloses an application of biotransformation bear gall powder for preparing an antibacterial medicine. The antimicrobial activity of the biotransformation bear gall powder is researched, and the in-vitro anti-purulency streptococcus and anti-pneumonia streptococcus experiment and the in vivo anti-pneumonia streptococcus experiment of the biotransformation bear gall powder are respectively carried out. Experiment results show the application of the biotransformation bear gall powder in preparing antibacterial medicines, and especially the application of the biotransformation bear gall powder in preparing an anti-purulency streptococcus orand anti-pneumonia streptococcus medicine.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to the application of biotransformed bear bile powder in the preparation of antibacterial drugs. Background technique [0002] Bear bile, obtained from the dried gallbladder bile of black bears or brown bears, has the effects of clearing away heat, calming the liver, and improving eyesight. Its main component is tauroursodeoxycholic acid (TUDCA). Bear bile is one of the four famous and precious animal medicines. It has a history of more than 2,000 years of use, and a large number of prescriptions contain bear bile. my country's annual output of bear bile powder is about 30 tons, which still cannot meet the needs of human health. At present, the contradiction between supply and demand of high-end bear bile powder is increasingly prominent and the market demand for bear bile powder for low-end raw materials continues to increase, which makes the price of bear bile powder rise steadi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/413A61K35/57A61P31/04
CPCA61K35/413A61K35/57A61P31/04
Inventor 穆竟伟马越鸣杨莉张小利王国明
Owner SHANGHAI KAIBAO PHARMA
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