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Method for preparing cold-soluble Dendrobium officinale extract

A technology of Dendrobium officinale and extract is applied in the field of preparation of cold-dissolving Dendrobium officinale extract, and can solve the problems of different effects of active ingredients, poor water solubility of polysaccharides, and untargeted application of active ingredients, and the like, To achieve the effects of easy absorption by the human body, high extraction rate and simple preparation method

Pending Publication Date: 2018-12-18
DAMIN FOODSTUFF ZHANGZHOU CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The medicinal effect of Dendrobium officinale is mainly because it contains a variety of active ingredients, such as alkaloids, polysaccharides, amino acids, etc., but the efficacy of various active ingredients is not the same
However, the clinical application of Dendrobium candidum mainly takes effect by making decoction from medicinal materials of Dendrobium candidum, and the efficacy of each active ingredient has not been targetedly applied. Therefore, some researchers have extracted and separated different active ingredients of Dendrobium candidum, and devoted Further development of medicinal value of Dendrobium officinale
At present, many researchers have extracted polysaccharides from Dendrobium candidum. Although many technologies have been able to obtain polysaccharides from Dendrobium candidum with high extraction rates, the water solubility of these extracted polysaccharides is not good, which affects the use of polysaccharides from Dendrobium candidum and the Pharmacological and pharmacodynamic studies of polysaccharides

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0014] A preparation method of cold-soluble dendrobium officinale extract, it comprises the following steps:

[0015] (1) crushing and soaking of Dendrobium candidum: adding hot water to soaking after the dendrobium candidum is pulverized, obtains initial feed liquid;

[0016] (2) Enzymolysis: add cellulase enzymolysis to the primary feed liquid described in step (1), and then add pectinase enzymolysis to obtain secondary feed liquid;

[0017] (3) Filtration: the secondary feed liquid of step (2) gained is filtered to obtain coarse feed liquid;

[0018] (4) Purification: the crude material liquid obtained in step (3) is adsorbed by a macroporous adsorption resin, then eluted with water-ethanol as the eluent, and the effluent is collected;

[0019] (5) concentration: the effluent collected in step (4) is concentrated to obtain a concentrated solution;

[0020] (6) cooling and filtering: the concentrated solution obtained in step (5) is cooled, then filtered, and the filtrate ...

Embodiment 1

[0036] A preparation method of cold-soluble dendrobium officinale extract, it comprises the following steps:

[0037] (1) Crushing and soaking of Dendrobium candidum: first crush the whole herb of Dendrobium candidum to 10 meshes, then add the crushed Dendrobium candidum to 60°C hot water and soak for 30 minutes to obtain the initial material liquid; wherein, the material of Dendrobium candidum and hot water The liquid ratio is 1:10g / mL.

[0038] (2) Enzymolysis: the initial feed solution of step (1) gained is cooled to 40 ℃, then adds the cellulase that accounts for 0.05% of the weight of Dendrobium candidum, and reacts for 45 minutes; After the reaction finishes, add 0.05% of the weight of Dendrobium candidum pectinase, hydrolyzed at 40°C for 60 minutes to obtain secondary feed solution.

[0039] (3) Filtration: The secondary feed liquid obtained in step (2) does not need to be cooled, and is directly firstly filtered through a 40-mesh filter to collect the filtrate; then t...

Embodiment 2

[0045] A preparation method of cold-soluble dendrobium officinale extract, it comprises the following steps:

[0046] (1) Crushing and soaking of Dendrobium candidum: first crush the whole herb of Dendrobium candidum to 15 meshes, then add the crushed Dendrobium candidum to 80°C hot water and soak for 60 minutes to obtain the initial material liquid; wherein, the material of Dendrobium candidum and hot water The liquid ratio is 1:15g / mL.

[0047] (2) Enzymolysis: the initial feed liquid of step (1) gained is cooled to 45 ℃, then adds the cellulase that accounts for 0.1% of the weight of Dendrobium candidum, and reacts for 60 minutes; After the reaction finishes, add 0.1% of the weight of Dendrobium candidum pectinase, hydrolyzed at 45°C for 90 minutes to obtain secondary feed solution.

[0048] (3) Filtration: The secondary feed liquid obtained in step (2) does not need to be cooled, and directly first uses an 80-mesh filter screen for thermal filtration to collect the filtra...

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Abstract

The invention relates to a method for preparing cold-soluble Dendrobium officinale extract. The method comprises the following steps: (1) crushing and soaking of Dendrobium officinale; (2) enzymatic hydrolysis; (3) filtration; (4) purification; (5) concentration; (6) cooling and filtration; and (7) drying and powder discharging for obtaining the cold-soluble Dendrobium officinale extract. The preparation method allows the water-soluble Dendrobium officinale extract to be obtained, and the Dendrobium officinale extract is Dendrobium officinale polysaccharides. The Dendrobium officinale extractcan be quickly dissolved in cold water, the minimum dissolution temperature can reach 8 DEG C, and 6 g of the Dendrobium officinale extract can be dissolved in 100 g of 8 DEG C water, so the Dendrobium officinale extract prepared in the invention is a cold-soluble substance. The Dendrobium officinale extract has good water solubility, so the Dendrobium officinale extract can be used in the deep researches of the pharmacology and efficacy of the Dendrobium officinale polysaccharides.

Description

technical field [0001] The invention relates to a preparation method of a cold-soluble dendrobium officinale extract. Background technique [0002] Dendrobium officinale is a perennial epiphytic herb of the family Dendrobium genus. It is the top grade of Dendrobium medicinal materials. It is sweet in taste, heavy in quality, flexible and sticky. Treatment of febrile disease, body fluid injury, deficiency of stomach yin, flaccidity of muscles and bones, etc. Modern pharmacological studies have shown that Dendrobium officinale can enhance both non-specific and specific immunity, and has significant pharmacological effects in anti-tumor, anti-oxidation, lowering blood sugar and treating cataracts. The medicinal effect of Dendrobium officinale is mainly because it contains a variety of active ingredients, such as alkaloids, polysaccharides, amino acids, etc., but the efficacy of various active ingredients is not the same. However, the clinical application of Dendrobium candidu...

Claims

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Application Information

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IPC IPC(8): A61K36/8984A23L33/105A61K135/00
CPCA23L33/105A61K36/8984A61K2236/19A61K2236/331A61K2236/51A61K2236/53A61K2236/55
Inventor 吴庆山赵祎武洪荣艺
Owner DAMIN FOODSTUFF ZHANGZHOU CO LTD
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