Application of SNP bite of CLIP3 gene

Abstract

The invention discloses a full-exon sequence detecting technology screening based and aortic dissection disease related SNP bite. The SNP bite comprises the following aortic dissection easily-sensed SNP bites: CLIP3: NM_001199570: exon1: c. 32C) T: p. P11L. The invention further provides application of the SNP bite in a detection product for detecting aortic dissection disease. According to the application, the aortic dissection easily-sensed SNP bite of SEQ ID NO.3 is found out, and the application prospect thereof in early prediction of the aortic dissection is researched. The gene bite related to the aortic dissection disease is possibly an early biomarker of the aortic dissection; and a new direction is supplied to further research the genetic molecular mechanism of the aortic dissection and explore a medicine target for early prevention and treatment of the aortic dissection.

Description

technical field

[0001] The invention relates to the technical field of biomedical detection, in particular to the application of the SNP site of the CLIP3 gene related to aortic dissection disease. Background technique

[0002] Aortic dissection (AD) refers to a series of external factors (such as high blood pressure, trauma, etc.), based on the presence or absence of lesions in the aortic wall itself, a breach in the aortic intima occurs. Blood in the aortic intimal breach invades the middle layer of the aortic wall, and the aortic middle layer is continuously torn and separated longitudinally, resulting in a state of coexistence of true and false aortic lumens. Aortic dissection has sudden onset, rapid development, and severe prognosis. Despite the continuous improvement of various current treatment methods, the morbidity and mortality of AD are still high, and if proper and timely treatment is not carried out, the mortality rate of AD is extremely high. It has been repo...

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