Uses of bicyclol and pharmaceutically acceptable derivative thereof in prevention or treatment of drug-induced liver damage

A therapeutic drug, bicyclol technology, applied in the prevention or treatment of drug-induced liver injury, bicyclol and its pharmaceutically acceptable derivatives, can solve the problems of liver injury, AST and ALT, and reduce serum ALT and AST, copy The effect of increasing the number, preventing or treating drug-induced liver injury

Inactive Publication Date: 2019-01-01
BEIJING UNION PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that long-term and excessive use of azithromycin and dic...

Method used

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  • Uses of bicyclol and pharmaceutically acceptable derivative thereof in prevention or treatment of drug-induced liver damage
  • Uses of bicyclol and pharmaceutically acceptable derivative thereof in prevention or treatment of drug-induced liver damage
  • Uses of bicyclol and pharmaceutically acceptable derivative thereof in prevention or treatment of drug-induced liver damage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: Animal experiments on mice for preventing or treating drug-induced liver injury caused by azithromycin with bicyclol

[0034] 80 healthy male KM mice (provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., certificate number: SCXK (Beijing) 2012-0001) were randomly divided into 8 groups, namely blank control group, azithromycin liver injury Model control group (model control group), 100mg / kg bicyclol prevention group (low dose prevention group), 200mg / kg bicyclol prevention group (medium dose prevention group), 300mg / kg bicyclol prevention group (high dose prevention group) , 100mg / kg bicyclol treatment group (low dose treatment group), 200mg / kg bicyclol treatment group (middle dose treatment group), 300mg / kg bicyclol treatment group (high dose treatment group), 10 in every group.

[0035] The mice in the blank control group had a normal diet throughout the experiment, and were not given azithromycin and bicyclol. After the experiment, th...

Embodiment 2

[0042] Embodiment 2: the mouse animal experiment of embodiment 1 keeps the detection of blood sample and liver tissue sample

[0043] ALT, AST, MDA, GSH, CAT, SOD, NO, NOS, ATPase were measured with corresponding kits produced and sold by Nanjing Jiancheng Bioengineering Research Institute; DNA and RNA were extracted with kits produced and sold by Dalian Bao Biological Company; ELISA kits were used to measure serum inflammatory factors IL-1β and TNF-α; liver tissue samples were made into pathological sections to observe the morphological changes. YBRGreen MIX was purchased from Nanjing Aibimeng Company.

[0044] 1. Protective effect of bicyclol on liver injury induced by azithromycin

[0045] Bicyclol preventive and therapeutic administration groups can reduce the elevation of serum ALT and AST in mice with azithromycin-induced liver injury, which is significantly different from the model control group, and has a certain dose-effect relationship. The results are shown in T...

Embodiment 3

[0145] Embodiment 3: Bicyclol prevention or treatment of drug-induced liver injury caused by diclofenac sodium animal experiment

[0146] 80 healthy male ICR mice (provided by Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., certificate number: SCXK (Beijing) 2012-0001) were randomly divided into 8 groups, namely blank control group, diclofenac sodium liver Injury model control group (model control group), 100mg / kg bicyclol prevention group (low dose prevention group), 200mg / kg bicyclol prevention group (medium dose prevention group), 300mg / kg bicyclol prevention group (high dose prevention group) ), 100mg / kg bicyclol treatment group (low dose treatment group), 200mg / kg bicyclol treatment group (middle dose treatment group), 300mg / kg bicyclol treatment group (high dose treatment group), 10 in every group.

[0147] The mice in the blank control group had a normal diet throughout the test period, and were not given diclofenac sodium and bicyclol, and the mice in the...

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PUM

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Abstract

The invention belongs to the technical field of chemical medicines, and relates to uses of bicyclol and a pharmaceutically acceptable derivative thereof in prevention or treatment of drug-induced liver damage. According to the present invention, with the application of the bicyclol and the pharmaceutically acceptable derivative thereof to prevent or treat drug-induced liver damage, the ALT level and the AST level in serum can be significantly reduced, the activity of citrate synthase can be significantly restored, the liver mitochondrial gene copy number can be significantly increased, and theexpressions of liver autophagy gene, liver oxidative stress gene, liver endoplasmic reticulum stress gene and liver mitochondrial Sab gene can be significantly increased.

Description

technical field [0001] The invention belongs to the technical field of chemical medicines, and relates to the use of bicyclol and its pharmaceutically acceptable derivatives for preventing or treating drug-induced liver injury. Background technique [0002] Bicyclol, the chemical name is 4,4'-dimethoxy-5,6,5',6'-bis(methylenedioxy)-2-hydroxymethyl-2'-methoxycarbonyl Biphenyl, an innovative anti-hepatitis drug with independent intellectual property rights developed by the Institute of Materia Medica, Chinese Academy of Medical Sciences, has obtained patent protection in 16 countries and regions, and is currently on the market in the form of oral tablets. [0003] The bicyclol raw material and its tablets obtained the national new drug certificate and production approval in 2001, and are exclusively produced by Beijing Union Medical College Pharmaceutical Factory. Bicyclol can reduce the increase of aminotransferase in acute liver injury caused by carbon tetrachloride, D-gala...

Claims

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Application Information

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IPC IPC(8): A61K31/36A61P1/16
CPCA61K31/36
Inventor 赵立敏李燕王晨
Owner BEIJING UNION PHARMA FACTORY
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