Implantable flexible neural electrode integrating optical stimulation and electrical recording
A light stimulation and electrode technology, applied in the field of microelectrodes, can solve the problems of reducing the immune rejection of brain tissue, and the application performance needs to be explored, and achieve the effect of improving long-term usability, good volt-ampere characteristics, and low impedance.
Pending Publication Date: 2019-01-18
ACADEMY OF MILITARY MEDICAL SCI
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Problems solved by technology
Studies have shown that implanted electrodes on the surface of fluffy materials can reduce the immune rejection of brain tissue. Polyvinyl alcohol / multi-walled carbon nanotubes (PVA / MWCNT) gels are used in nerve electrode modification due to their good biocompatibility and mechanical properties. However, its application performance as a flexible nerve electrode modification material remains to be explored.
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[0043] The present invention will be described in detail below in conjunction with the drawings and embodiments, but the implementation of the present invention is not limited to this.
[0044] Such as figure 1 As shown, a flexible nerve electrode integrated with light stimulation and electrical recording is composed of an electrode body 1, an electrical signal interface 2 and an optical fiber ferrule 3. A section of electrode microwire extends from the rear of the electrode body, and the end 131 of the electrode microwire is connected to the pin 21 at the bottom of the electrical signal interface by welding; the outer diameter of the electrode body 1 exactly matches the inner diameter of the optical fiber ferrule 3. The rear section of the electrode body 1 can be inserted into the optical fiber ferrule. In this embodiment, the three are encapsulated as a whole by epoxy resin glue.
[0045] Such as figure 2 Shown as a schematic longitudinal cross-sectional view of the electrode ma...
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The invention discloses a flexible neural electrode integrating optical stimulation and electrical recording in the technical field of neural engineering and brain science. The electrode has flexibleencapsulation. And the outer layer of the electrode has the elastic modulus similar to the brain tissue, which reduces the mechanical damage to the brain tissue in the electrode implantation process.The long-term usability of the electrode implantation is improved because of the good biocompatibility of the outer layer of the electrode material. The PEDOT / PSS / MWCNT modified electrode has lower impedance and better voltammetric characteristics, which can significantly improve its electrical and biological properties.
Description
Technical field [0001] The invention belongs to the technical field of microelectrodes of neural engineering and brain science, and specifically relates to a flexible neural electrode integrated with light stimulation and electrical recording and a preparation method thereof. Background technique [0002] Optogenetic technology provides neuroscience with a research method of changing personality, which can realize the regulation of specific types of neuron activity. In optogenetic research, the photoelectrode plays a role in delivering light stimulation to the target area, and under the promotion of recent research, it has developed multiple functions such as electrical signal recording and drug delivery with the light stimulation area at the same time. Initially, the main form of photoelectrodes was the integration of optical fibers and microwire electrodes to achieve optical stimulation while recording neuronal electrical signals (Alexexai VKiavite, Keita Tamura, etc.), which c...
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IPC IPC(8): A61B5/04A61N5/06
CPCA61N5/0622A61B5/24
Inventor 王常勇周瑾李斯伟赵宇伟
Owner ACADEMY OF MILITARY MEDICAL SCI