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Application of bruceine A in preparation of drug for prevention and treatment of osteoporosis

A technology for osteoporosis and brucea, which is applied in drug combinations, bone diseases, and pharmaceutical formulations, can solve problems such as heavy burden, great harm, and side effects, and achieve increased bone volume fraction and trabecular bone thickness , reverse the effect of trabecular bone loss

Active Publication Date: 2019-01-18
MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Osteoporosis is a metabolic imbalance between bone resorption and bone production, characterized by decreased bone mass, damage to the fine structure of bone tissue, and increased risk of fragility fractures. The most serious consequence of osteoporosis is fragility fractures. increase the rate of disability and mortality; in addition, the society needs to invest a lot of manpower and material resources in the care and prevention of osteoporosis, which creates a heavy burden on the family and society
[0004] At present, the drug treatment of osteoporosis mainly uses two methods of anti-bone resorption and bone-promoting. Most of the anti-osteoporosis drugs that have been marketed still have many side effects while exerting their curative effect. For example, teriparatide Subcutaneous injection of the representative parathyroid hormone is inconvenient, and other therapeutic drugs (such as drugs that inhibit bone resorption) need to be used after more than 24 months of use; estrogen drugs can inhibit bone resorption and reduce bone turnover in postmenopausal women However, long-term use has side effects; bisphosphonates have side effects such as hypocalcemia, esophageal irritation, atypical femur fracture, kidney irritation, and rare osteonecrosis of the jaw

Method used

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  • Application of bruceine A in preparation of drug for prevention and treatment of osteoporosis
  • Application of bruceine A in preparation of drug for prevention and treatment of osteoporosis

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Embodiment 1

[0022] Material:

[0023] 8-week-old osteoporosis model mice db / db mice and healthy control db / m mice (both SPF grade) were purchased from Nanjing University-Nanjing Institute of Biomedicine; Company; Micro CT detection system purchased from Germany Siemens.

[0024] Animal feeding and grouping:

[0025] The experimental mice were raised in the experimental animal barrier system of the Institute of Medical Biotechnology, Chinese Academy of Medical Sciences, given normal feed, free to eat and drink, and alternately illuminated 12 hours a day. The experiment has been approved by the Animal Experiment Ethics Committee of the Institute of Medical Biotechnology, Chinese Academy of Medical Sciences.

[0026] 30 db / db mice were randomly divided into 3 groups, 10 in each group, respectively osteoporosis model group, BA low-dose group (0.5mg / kg), BA high-dose group (5mg / kg), and a control group 10 db / m mice.

[0027] Dosing regimen:

[0028] After the 8-week-old experimental mice w...

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Abstract

The invention provides application of bruceine A in preparation of drug for prevention and treatment of osteoporosis, and belongs to the technical field of traditional Chinese medicine preparation andapplication. The present invention provides a new application of bruceain A, according to the embodiment. bruceain A can significantly increase bone mass, reverse trabecular bone loss, increase bonevolume fraction and trabecular thickness, and play a role in prevention and treatment of osteoporosis.

Description

technical field [0001] The invention belongs to the technical field of preparation and application of traditional Chinese medicines, and in particular relates to the application of brucetin A in the preparation and prevention of osteoporosis. Background technique [0002] Osteoporosis is one of the common clinical bone diseases, and it is the seventh most common disease in the world. With the advent of an aging society, the incidence rate is increasing at an alarming rate. According to the epidemiological survey in my country in 2010, the prevalence rate of osteoporosis in women over 70 years old is 40.0% to 59.3%, and that in men is 14.2% to 18.9%. , Prevention and treatment of osteoporosis has become a research hotspot today. [0003] Osteoporosis is a metabolic imbalance between bone resorption and bone production, characterized by decreased bone mass, damage to the fine structure of bone tissue, and increased risk of fragility fractures. The most serious consequence of o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/366A61P19/10
CPCA61K31/366A61P19/10
Inventor 王真赵晓丽李会英林帅邱强
Owner MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
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