Application of brucetin a in the preparation of drugs for preventing and treating osteoporosis
A technology for osteoporosis and bruceicin, applied in the direction of drug combinations, pharmaceutical formulas, bone diseases, etc., can solve the problems of great harm, heavy burden, side effects, etc., to reverse the loss of trabecular bone and increase trabecular bone Thickness, effect of increasing bone volume fraction
Active Publication Date: 2021-05-04
MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI
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Problems solved by technology
[0003] Osteoporosis is a metabolic imbalance between bone resorption and bone production, characterized by decreased bone mass, damage to the fine structure of bone tissue, and increased risk of fragility fractures. The most serious consequence of osteoporosis is fragility fractures. increase the rate of disability and mortality; in addition, the society needs to invest a lot of manpower and material resources in the care and prevention of osteoporosis, which creates a heavy burden on the family and society
[0004] At present, the drug treatment of osteoporosis mainly uses two methods of anti-bone resorption and bone-promoting. Most of the anti-osteoporosis drugs that have been marketed still have many side effects while exerting their curative effect. For example, teriparatide Subcutaneous injection of the representative parathyroid hormone is inconvenient, and other therapeutic drugs (such as drugs that inhibit bone resorption) need to be used after more than 24 months of use; estrogen drugs can inhibit bone resorption and reduce bone turnover in postmenopausal women However, long-term use has side effects; bisphosphonates have side effects such as hypocalcemia, esophageal irritation, atypical femur fracture, kidney irritation, and rare osteonecrosis of the jaw
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Embodiment 1
[0022] Material:
[0023] 8-week-old osteoporosis model mice db / db mice and healthy control db / m mice (both SPF grade) were purchased from Nanjing University-Nanjing Institute of Biomedicine; Company; Micro CT detection system purchased from Germany Siemens.
[0024] Animal feeding and grouping:
[0025] The experimental mice were raised in the experimental animal barrier system of the Institute of Medical Biotechnology, Chinese Academy of Medical Sciences, given normal feed, free to eat and drink, and alternately illuminated 12 hours a day. The experiment has been approved by the Animal Experiment Ethics Committee of the Institute of Medical Biotechnology, Chinese Academy of Medical Sciences.
[0026] 30 db / db mice were randomly divided into 3 groups, 10 in each group, respectively osteoporosis model group, BA low-dose group (0.5mg / kg), BA high-dose group (5mg / kg), and a control group 10 db / m mice.
[0027] Dosing regimen:
[0028] After the 8-week-old experimental mice w...
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The present invention provides the application of brucein A in the preparation of drugs for the prevention and treatment of osteoporosis, which belongs to the technical field of preparation and application of traditional Chinese medicine. Cholin A can significantly increase bone mass, reverse bone trabecular loss, increase bone volume fraction and bone trabecular thickness, and play a role in preventing and treating osteoporosis.
Description
technical field [0001] The invention belongs to the technical field of preparation and application of traditional Chinese medicines, and in particular relates to the application of brucetin A in the preparation and prevention of osteoporosis. Background technique [0002] Osteoporosis is one of the common clinical bone diseases, and it is the seventh most common disease in the world. With the advent of an aging society, the incidence rate is increasing at an alarming rate. According to the epidemiological survey in my country in 2010, the prevalence rate of osteoporosis in women over 70 years old is 40.0% to 59.3%, and that in men is 14.2% to 18.9%. , Prevention and treatment of osteoporosis has become a research hotspot today. [0003] Osteoporosis is a metabolic imbalance between bone resorption and bone production, characterized by decreased bone mass, damage to the fine structure of bone tissue, and increased risk of fragility fractures. The most serious consequence of o...
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IPC IPC(8): A61K31/366A61P19/10
CPCA61K31/366A61P19/10
Inventor 王真赵晓丽李会英林帅邱强
Owner MEDICINE & BIOENG INST OF CHINESE ACAD OF MEDICAL SCI