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Medicine for treating renal injury caused by lithium salt and use thereof

A kidney injury, lithium salt technology, applied in the field of medicine, can solve problems such as no improvement in urine concentration function

Active Publication Date: 2019-01-18
郑士平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Acetazolamide has been shown to improve polyuria associated with lithium-induced renal injury, but has no effect on urine concentration

Method used

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  • Medicine for treating renal injury caused by lithium salt and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Oral tablets for treating kidney injury caused by lithium salt

[0023] Party:

[0024] Ta Bonin 25g

[0025] N-acetylcysteine ​​250g

[0026] 700g of lactose

[0027] Microcrystalline cellulose 400g

[0028] Hydroxypropyl cellulose 100g

[0029] Sodium starch glycolate 60g

[0030] Magnesium stearate 90g

[0031] Polyethylene glycol 6000 80g

[0032] Povidone K30 61g

[0033] Take the prescription amount of Tabonine, N-acetylcysteine, lactose, microcrystalline cellulose, hydroxypropyl cellulose, sodium starch glycolate, magnesium stearate, polyethylene glycol 6000, and povidone K30. 80 mesh sieve;

[0034] Take the prescription amount of Povidone K30 and add water to prepare an aqueous solution with a concentration of 5%;

[0035] Take the prescription amount of Tabonine, N-acetylcysteine, lactose, hydroxypropyl cellulose, polyethylene glycol 6000 and 200g microcrystalline cellulose and mix them uniformly, and then use povidone K30 aqueous solution to prepare soft material, a...

Embodiment 2

[0036] Example 2 Oral tablets for treating kidney injury caused by lithium salt

[0037] Party:

[0038] Ta Bonin 25g

[0039] N-acetylcysteine ​​375g

[0040] 700g of lactose

[0041] Microcrystalline cellulose 400g

[0042] Hydroxypropyl cellulose 100g

[0043] Sodium starch glycolate 60g

[0044] Magnesium stearate 90g

[0045] Polyethylene glycol 6000 80g

[0046] Povidone K30 61g

[0047] Take the prescription amount of Tabonine, N-acetylcysteine, lactose, microcrystalline cellulose, hydroxypropyl cellulose, sodium starch glycolate, magnesium stearate, polyethylene glycol 6000, and povidone K30. 80 mesh sieve;

[0048] Take the prescription amount of Povidone K30 and add water to prepare an aqueous solution with a concentration of 5%;

[0049] Take the prescription amount of Tabonine, N-acetylcysteine, lactose, hydroxypropyl cellulose, polyethylene glycol 6000 and 200g microcrystalline cellulose and mix them uniformly, and then use povidone K30 aqueous solution to prepare soft material, a...

Embodiment 3

[0050] Example 3 Oral tablets for treating kidney injury caused by lithium salt

[0051] Party:

[0052] Ta Bonin 25g

[0053] N-acetylcysteine ​​500g

[0054] 700g of lactose

[0055] Microcrystalline cellulose 400g

[0056] Hydroxypropyl cellulose 100g

[0057] Sodium starch glycolate 60g

[0058] Magnesium stearate 90g

[0059] Polyethylene glycol 6000 80g

[0060] Povidone K30 61g

[0061] Take the prescription amount of Tabonine, N-acetylcysteine, lactose, microcrystalline cellulose, hydroxypropyl cellulose, sodium starch glycolate, magnesium stearate, polyethylene glycol 6000, and povidone K30. 80 mesh sieve;

[0062] Take the prescription amount of Povidone K30 and add water to prepare an aqueous solution with a concentration of 5%;

[0063] Take the prescription amount of Tabonine, N-acetylcysteine, lactose, hydroxypropyl cellulose, polyethylene glycol 6000 and 200g microcrystalline cellulose and mix them uniformly, and then use povidone K30 aqueous solution to prepare soft material, a...

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PUM

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Abstract

The invention belongs to the field of medicine, in particular to a medicine for treating renal injury caused by lithium salts and use thereof. The active ingredients of the medicine for treating lithium salt-induced kidney injury are tabonine and a thiol antioxidant, wherein the thiol antioxidant is preferably N-Acetylcysteine. The drug is preferably an oral tablet, and the pharmaceutical adjuvantis preferably lactose, microcrystalline cellulose, hydroxypropyl cellulose, sodium carboxymethyl starch, magnesium stearate, polyethylene glycol 6000, and polyvidone. The pharmaceutical adjuvant is preferably lactose, microcrystalline cellulose, hydroxypropyl cellulose, sodium carboxymethyl starch, magnesium stearate, polyethylene glycol 6000, and polyvidone. These drugs can improve the renal pathological changes and specific symptoms of renal injury induced by lithium salt.

Description

Technical field [0001] The invention belongs to the field of medicine, and specifically relates to a medicine for treating kidney damage caused by lithium salt and its use. Background technique [0002] Metal salt drugs have been widely used in the treatment of human diseases, such as iron salts, calcium salts, and lithium salts. Among them, oral preparations of lithium salts such as lithium carbonate have been approved for the treatment of mania, which has a good therapeutic and preventive effect on bipolar disorder with alternating episodes of mania and depression, and can also prevent recurrent episodes of depression. It can also be used to treat schizoaffective psychosis. [0003] For the treatment of mental diseases, drugs often need to be used for a long time to maintain the control effect on mental activity. Long-term use of drugs often causes damage to organs. As early as 1876, humans have noticed the effects of lithium on the kidneys, and then reports of acute kidney da...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/438A61K31/198A61P13/12
CPCA61K31/198A61K31/438A61P13/12A61K2300/00
Inventor 郑士平宋秀艳张晶
Owner 郑士平