Microwave solid-phase method for synthesizing tetraphenylporphyrinatozinc (II)

Abstract

The invention discloses a microwave solid-phase method for synthesizing tetraphenylporphyrinatozinc (II). The microwave solid-phase method comprises the following preparation steps: (1) weighing malonic acid, potassium phthalimide and zinc acetate, and mixing and grinding to obtain mixed powder; (2) irradiating the mixed powder through microwaves and completely reacting to obtain a reactant; (3) after cooling the reactant in a dark place, carrying out column chromatography separation. The microwave solid-phase method has the beneficial effects that (1) reaction is carried out under a solid phase, reaction environments are wide, the limitation on reaction conditions is small and the practicality is strong; (2) microwave three-dimensional heating reaction is adopted so that the reaction timeis effectively shortened, a reaction energy barrier is reduced, no thermal sublimation occurs and the yield is improved; (3) the reaction does not need a solvent and utilization and recycling of thesolvent can be avoided so that the cost is reduced; (4) no solvent participates in the reaction and purification is facilitated.

Description

technical field [0001] The invention belongs to the field of organic synthesis, and in particular relates to a synthesis method of tetrabenzoporphyrin zinc (II). Background technique [0002] Metalloporphyrin compounds and their derivatives are a class of macrocyclic aromatic compounds containing 18r electronic structures, which are widely used in the fields of cancer diagnosis and identification, catalysis, photocells, molecular recognition, and photosensitive materials. It can also simulate physiological processes in living organisms and deal with NO in automobile exhaust x Wait. [0003] At present, the methods for synthesizing metalloporphyrin compounds include Alder synthesis method, Lindesy synthesis method, Guo Cancheng's new synthesis method and Gaode's improved new method. These conventional synthetic methods have many operating steps, long reaction times and low yields. The solid direct heating method has serious sublimation and low yield (up to 15%), and also h...

AI Technical Summary

Problems solved by technology

These conventional synthetic methods have many operating steps, long reaction times and low yields.

Due to the serious sublimation of the solid direct heating method, the yield is not high (up to 15%), and there are also disadvantages such as complicated operation, long reaction time, and difficult separation and purification.

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