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A molecularly imprinted ratiometric fluorescent sensor and its preparation and application

A ratiometric fluorescence, molecular imprinting technology, applied in the fields of chemistry, materials and food testing, can solve the problems of unstable fluorescence detection, instrument fluctuation, changing fluorescence intensity, etc.

Active Publication Date: 2019-03-26
YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are two main deficiencies in molecularly imprinted fluorescent sensors: (1) Fluorescence detection is unstable, and will be interfered by various factors that are not related to the target, resulting in data distortion, such as background fluorescence, instrument fluctuations, etc.; (2) Traditional molecularly imprinted fluorescent sensors have only one emission peak, and can only change the fluorescence intensity when detecting the target, which is limited to light and dark changes visually, and cannot provide more direct color changes

Method used

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  • A molecularly imprinted ratiometric fluorescent sensor and its preparation and application
  • A molecularly imprinted ratiometric fluorescent sensor and its preparation and application
  • A molecularly imprinted ratiometric fluorescent sensor and its preparation and application

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Embodiment 1

[0039] Such as figure 1 with figure 2 As shown, a method for preparing a molecularly imprinted ratiometric fluorescent sensor, the steps are as follows:

[0040] (1) Preparation of dual fluorescent emission CdTe / ZnQ 2 Nanoparticles: Add 8 mL of CdTe quantum dots to a mixed solution of 25 mL of zinc chloride (1 mmol / L) and glutathione (4 mmol / L), stir well, and react at pH 8 at 100 °C After 40 minutes, a CdTe / ZnS quantum dot solution was obtained. Take 14mL of CdTe / ZnS quantum dot solution, add 50 μL of 8-hydroxyquinoline ethanol solution (15 mmol / L), and stir for 15 minutes to obtain double fluorescence emission CdTe / ZnQ 2 Nanoparticle solution.

[0041] (2) Molecularly imprinted ratiometric sensors (MIPs) prepared by sol-gel method: to the above CdTe / ZnQ 2 Add 37 μL APTES and 3.2 mg brilliant blue to the nanoparticle solution, stir for 1 hour, then add 800 μL CTAB (0.2mol / L), 100 μL sodium hydroxide (0.2 mol / L), 178 μL TEOS and 178 μL ammonia water , react in a dark en...

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Abstract

The invention belongs to the fields of chemistry, materials and food safety, and relates to a molecular imprinting ratio fluorescent sensor, a preparation method and application thereof. The preparation method of the molecular imprinting ratio fluorescent sensor includes the steps that molecular imprinting is carried out through sol-gel polymerization, single-component dual-fluorescence emission cadmium telluride / 8-hydroxyquinoline zinc nanoparticles provide fluorescence signals, holes after eluting bright blue are recognition sites, a mesoporous structure is formed after hexadecyl trimethyl ammonium bromide is eluted, and bright blue imprinted microspheres with the mesoporous structure are obtained, that is, the molecular imprinting ratio fluorescent sensor based on the single-component dual-fluorescence emission nanoparticles. According to the molecular imprinting ratio fluorescent sensor, preparation and application thereof, the obtained sensor prepared by the preparation method candetect bright blue with high selectivity and sensitivity, and provides color evolution and self-correction functions; and in addition, by effectively adjusting the emission wavelength of the sensor,the molecular imprinting ratio fluorescent sensor can be more widely used in detection of various colored substances.

Description

technical field [0001] The invention relates to the technical fields of chemistry, materials and food detection, in particular to a molecular imprinted ratio fluorescence sensor and its preparation and application. Background technique [0002] Colorants have been used in the food industry for a long time, with the main purpose of imparting and improving food color and increasing the sensory appeal of food. Compared with natural food colorants, food synthetic colorants have higher physical and chemical stability, and are of high quality and low price. However, long-term excessive intake of synthetic coloring agents will affect the health of consumers, which may cause poisoning, allergies, asthma and even cancer; it will also affect the behavior of young children, such as ADHD. With the improvement of people's food safety awareness, it is imminent to develop a method that can quickly, conveniently and reliably detect the content of synthetic colorants in food. [0003] Mole...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/64
CPCG01N21/6402
Inventor 陈令新杨倩李金花
Owner YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
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