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Joint cavity injection preparation and application thereof

A technology for injection preparations and joint cavity, which is applied in the direction of medical preparations containing active ingredients, bone diseases, organic active ingredients, etc. It can solve the problems of not easy to degrade, affect the use effect, and slow removal, and achieve good biocompatibility and safety effect

Active Publication Date: 2019-01-25
SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent application 2017100752628 discloses pharmaceutical preparations containing low molecular weight xanthan gum for intra-articular injection and its preparation method, and mentions that pharmaceutical preparations containing low molecular weight xanthan gum with a relative molecular mass of 100,000-1.99 million can be used to prevent rheumatism, class Rheumatoid arthritis, osteoarthritis, the role of protecting articular cartilage in osteoarthritis and repairing damaged articular cartilage, mainly solves the problem that xanthan gum with conventional molecular weight (relative molecular weight is 2 million to 20 million) is not easily absorbed by enzymes in vivo due to its stability. and free radical degradation, difficult to be excreted by the body's metabolism
However, low-molecular-weight xanthan gum pharmaceutical preparations are used in the treatment of osteoarthritis. Due to their stable structure, they enter the visceral tissues through the blood circulation after intra-articular injection. Dosage injection is likely to cause the disadvantages of increased spleen weight and mononuclear cell count, and poor biocompatibility, which seriously affects its use effect and hinders its further use; and deacetylated xanthan gum with a considerable molecular weight, even with a higher molecular weight and concentration High deacetylated xanthan gum can solve the above problems well while ensuring excellent therapeutic effect

Method used

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  • Joint cavity injection preparation and application thereof
  • Joint cavity injection preparation and application thereof
  • Joint cavity injection preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The preparation method of deacetylated xanthan gum:

[0030] Take 10g of xanthan gum with a molecular weight of 3 million and fully dissolve it in 1000mL of water, adjust the pH to 11, stir at a temperature of 50°C for 0.5h, adjust the pH to 2.0, place it at 0.1MPa for 20min, adjust the pH to 7.0 after cooling, use Precipitate with ethanol, and dry the precipitated product under reduced pressure at 40°C for 24h, to obtain.

[0031] The Mw of the deacetylated xanthan gum detected by multi-angle laser is 1 million, and the hydroxylamine hydrochloride colorimetric method is used to detect that there is no acetyl group in its structure.

Embodiment 2

[0033] The preparation method of deacetylated xanthan gum:

[0034] Take 20g of xanthan gum with a molecular weight of 3 million and fully dissolve it in 1000mL of water, adjust the pH to 11, stir at 60°C for 2 hours, adjust the pH to 3.0, place it at 0.1MPa for 30 minutes, adjust the pH to 7.0 after cooling, and use ethanol Precipitate, and the precipitated product is dried under reduced pressure at 40°C for 24h to obtain it.

[0035] The Mw of the deacetylated xanthan gum detected by multi-angle laser is 2 million, and the hydroxylamine hydrochloride colorimetric method is used to detect that there is no acetyl group in its structure.

Embodiment 3

[0037] The preparation method of deacetylated xanthan gum:

[0038] Take 30g of xanthan gum with a molecular weight of 5 million and fully dissolve it in 1000mL of water, adjust the pH to 12, stir at a temperature of 50°C for 1 hour, adjust the pH to 5.0, place it at 0.1MPa to react for 20 minutes, adjust the pH to 7.0 after cooling, and use ethanol Precipitate, and the precipitated product is dried under reduced pressure at 40°C for 24h, to obtain.

[0039] The Mw of the deacetylated xanthan gum detected by multi-angle laser is 4 million, and the hydroxylamine hydrochloride colorimetric method is used to detect that the structure does not contain acetyl groups.

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Abstract

The invention relates to the technical field of orthopaedics medicine, in particular to a joint cavity injection preparation and application thereof. Compared with the existing xanthan gum joint cavity injection preparation, the deacetylated xanthan gum joint cavity injection preparation has excellent therapeutic effect, can ensure better biocompatibility, has higher safe dose range, and is saferto use.

Description

technical field [0001] The invention relates to the technical field of orthopedic medicine, in particular to a preparation for intra-articular injection and its application. Background technique [0002] Osteoarthritis (OA) is a common degenerative joint disease characterized by destruction of articular cartilage and bone hyperplasia, and the incidence is higher in the elderly. With the aging of the population and the increase in the number of obese people in my country, the incidence of OA continues to rise. In OA lesions, the viscoelasticity of synovial fluid is significantly reduced, and cartilage is degraded and destroyed, resulting in joint dysfunction. [0003] Viscosupplementation (viscosupplementation) is one of the main methods of clinical treatment of OA. By injecting exogenous hyaluronic acid (HA) into the joint cavity, it can restore the lubrication and buffer function of joint synovial fluid and promote the repair of cartilage tissue. Relieve OA symptoms and i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/723A61K9/08A61P19/02C08B37/02
CPCA61P19/02A61K9/0019A61K9/08A61K31/723C08B37/0033A61K31/722A61K31/7016A61K31/728A61K31/737
Inventor 凌沛学刘飞邵华荣陈磊张治云张晓元陈启鑫韩冠英程艳玲张建强张岱州
Owner SHANDONG ACADEMY OF PHARMACEUTICAL SCIENCES
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