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A method for preparing n-acetylneuraminic acid by converting n-acetylneuraminic acid hydrate with an organic solvent

A technology of acetylneuraminic acid and organic solvent, which is applied in the field of chemical engineering and achieves the effects of satisfying market demand, high product purity and low cost

Active Publication Date: 2022-04-19
武汉中科光谷绿色生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to solve the problem of converting N-acetylneuraminic acid hydrate to N-acetylneuraminic acid, the present invention provides a method for preparing N-acetylneuraminic acid by converting N-acetylneuraminic acid hydrate with an organic solvent. Obtain N-acetylneuraminic acid with high purity and stable quality to meet the application needs of health care, medicine and other fields

Method used

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  • A method for preparing n-acetylneuraminic acid by converting n-acetylneuraminic acid hydrate with an organic solvent
  • A method for preparing n-acetylneuraminic acid by converting n-acetylneuraminic acid hydrate with an organic solvent

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Embodiment 1

[0021] In this implementation, N-acetylneuraminic acid is prepared from N-acetylneuraminic acid hydrate using an organic solvent as follows:

[0022] 1. Select N-acetylneuraminic acid dihydrate as raw material, and the purity of N-acetylneuraminic acid dihydrate is 98.2%.

[0023] 2. Weigh 10g of the above-mentioned N-acetylneuraminic acid dihydrate, and weigh 60g of ethanol according to the weight ratio of N-acetylneuraminic acid hydrate to ethanol is 6:1;

[0024] 3. Pour the above ethanol into the weighed N-acetylneuraminic acid dihydrate container, and put it into a 30°C water bath for stirring, and keep stirring until all the hydrates are converted into N-acetylneuraminic acid until.

[0025] 4. Filter the converted N-acetylneuraminic acid, filter with filter paper, and then quickly rinse twice with pure water.

[0026] 5. The above washed N-acetylneuraminic acid was put into an oven for drying at 80° C., and then detected by high performance liquid chromatography, the ...

Embodiment 2

[0028] In this implementation, N-acetylneuraminic acid is prepared by dehydrating N-acetylneuraminic acid hydrate with an organic solvent as follows:

[0029] 1. Select N-acetylneuraminic acid dihydrate as raw material, and the purity of N-acetylneuraminic acid dihydrate is 98.5%.

[0030] 2. Weigh 10g of the above-mentioned N-acetylneuraminic acid dihydrate, and at the same time weigh 80g of ethanol according to the ratio of N-acetylneuraminic acid hydrate to ethanol 8:1;

[0031] 3. Pour the above ethanol into the weighed container of N-acetylneuraminic acid dihydrate, and put it into a 60°C water bath for stirring until all the hydrates are converted into N-acetylneuraminic acid until.

[0032] 4. Filter the converted N-acetylneuraminic acid, filter with filter paper, and then quickly rinse twice with pure water.

[0033] 5. The above washed N-acetylneuraminic acid was put into an oven for drying at 60° C., and then detected by high performance liquid chromatography, the ...

Embodiment 3

[0035] This implementation follows the steps of Example 2, except that the ratio of N-acetylneuraminic acid hydrate to ethanol in step 2 is 11:1, the others are the same as the steps of Example 2, and the purity of the finally obtained N-acetylneuraminic acid is 95%. %.

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Abstract

The invention discloses a method for preparing N-acetylneuraminic acid by using an organic solvent to transform N-acetylneuraminic acid hydrate. Under stirring conditions, N-acetylneuraminic acid hydrate is converted into N-acetylneuraminic acid, and then filtered, washed and dried to obtain N-acetylneuraminic acid. This method has simple process, complete conversion reaction and high product purity, which can satisfy the conversion of N-acetylneuraminic acid hydrate to N-acetylneuraminic acid in the industrial production process of N-acetylneuraminic acid. Methods to prepare high-purity N-acetylneuraminic acid.

Description

technical field [0001] The invention relates to a method for preparing N-acetylneuraminic acid by converting N-acetylneuraminic acid hydrate, which is also a preparation method for high-purity N-acetylneuraminic acid monomer, and belongs to the technical field of chemical engineering. Background technique [0002] N-acetylneuraminic acid hydrate is a single crystal compound with high purity and wide application, and can be used in cosmetics, food and other fields. Although the purity of N-acetylneuraminic acid hydrate is very high, it is not suitable for some application fields. For example, in some pharmaceutical synthesis fields, when the application requires no water, N-acetylneuraminic acid hydrate is not suitable. For example, in the preparation of some health care products, in the process of compatibility with other ingredients, due to the need to maintain the stability of the compatibility, moisture may not be needed, and N-acetylneuraminic acid hydrate is also inappr...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H7/033C07H1/00
CPCC07H1/00C07H7/033
Inventor 袁丽霞陈祥松孙立洁吴金勇李翔宇姚建铭朱薇薇王纪王刚王煜费贤春
Owner 武汉中科光谷绿色生物技术有限公司