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Antibacterial liquid dressing for wounds and preparation method thereof

A technology for liquid dressing and wound surface, which is applied in the fields of medical science and bandages to achieve the effects of long-term release, easy application, good practical value and significance of promotion and application.

Inactive Publication Date: 2019-02-01
HENAN HUIBO MEDICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The main purpose of this application is to provide an antibacterial liquid dressing product, which can partially overcome and solve the product defects of existing liquid band-aid products for wound surface, so as to better meet people's medical protection needs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment

[0040] The technical solution of the present application is explained in detail below in conjunction with the embodiments. Before introducing the specific embodiments, a brief introduction of some materials involved in the following embodiments is as follows.

[0041] Experimental raw materials:

[0042] Nitrocellulose (CAS No.: 9004-70-0), chemically pure (>99%); Shandong West Asia Reagent;

[0043] Isopropyl Alcohol (CAS No. 67-63-0), Pharmaceutical Grade; Ethyl Acetate (CAS No. 141-78-6, Pharmaceutical Grade; Benzyl Alcohol (CAS No.: 100-51-6), Pharmaceutical Grade; Both It is a product of Jiangxi Alpha Hi-Tech Pharmaceutical Co., Ltd.;

[0044] Castor oil (CAS No.: 8001-79-4), pharmaceutical grade; Hunan Erkang Pharmaceutical Co., Ltd.;

[0045] Glycerin (CAS No.: 56-81-5), pharmaceutical grade; Jiangsu Taike Zonghua Pharmaceutical Co., Ltd.;

[0046] Octenidine hydrochloride (CAS No.: 70775-75-6), pharmaceutical grade; Wuhan Jiesheng Biotechnology Co., Ltd.;

[0047]...

Embodiment 1

[0049] This example briefly introduces the preparation method of the antibacterial chitosan and octenidine hydrochloride embedding involved in the antibacterial liquid dressing product for wounds provided by the present application as follows.

[0050] (1) Dissolve 4.0g chitosan oligosaccharide in 500ml purified water, then add 4.0g tragacanth gum, 9.0g Tween 80, 0.4g octenidine hydrochloride, and homogeneously emulsify at 10000rpm for 10min;

[0051] (2) Add the homogeneous emulsified solution in step (1) to the chitosan acetic acid solution (0.5g chitosan is dissolved in 50ml 1.0% acetic acid solution);

[0052] (3) Use 5% acetic acid solution to adjust the pH of the mixed solution in step (2) to about 5.0, stir and react at 55°C for 30 minutes, then add 0.2 g of cross-linking agent to cross-link and cure for 4 hours, after the cross-linking and curing is completed, adjust the pH to about 7.0 , continue to stir for 3h;

[0053] The crosslinking agent is carbodiimide hydrochlo...

Embodiment 2~3

[0056] Based on the antibacterial materials prepared in the examples, the inventors have prepared antibacterial liquid dressing products for wounds with different ratios. The specific preparation methods are as follows.

[0057] (1) In the mixing tank, add volatile agent, pain reliever, and then add film-forming agent, mix evenly and swell for about 6 hours to ensure sufficient swelling,

[0058] (2) After swelling in step (1), antibacterial substances, plasticizers, and humectants in the material were stirred at 50 rpm for 2 hours to ensure uniform mixing, and finally sealed and vacuumed for 30 minutes under a negative pressure of 0.08MPA to obtain no bubbles, transparent, colorless and viscous The thick liquid is the antibacterial liquid dressing product for wounds provided by this application.

[0059] In embodiment 2, the concrete proportioning of each material is:

[0060] 3% film-forming agent nitrocellulose, 0.1% antibacterial chitosan and octenidine hydrochloride embe...

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PUM

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Abstract

Belonging to the technical field of antibacterial drugs, the invention in particular relates to an antibacterial liquid dressing product for wounds. By mass percentage, the product comprises: 3-6.5% of a film-forming agent, 0.1-0.3% of an antibacterial substance and the balance a volatile agent. The preferable composition also includes: 0.55-3.2% of an analgesic agent, 0.5-1.5% of a plasticizer and 0.5-2% of a moisturizing agent. The film-forming agent is nitrocellulose. The antibacterial substance is a chitosan oligosaccharide-octenidine hydrochloride embedded substance. The specific preparation process includes: preparation of the antibacterial chitosan oligosaccharide-octenidine hydrochloride embedded substance, preparation of the antibacterial chitosan-octenidine hydrochloride embeddedsubstance and other steps. In general, the antibacterial liquid dressing product for wounds provided by the invention has good long-acting antibacterial effect, can adapt wounds at different parts and of different areas. At the same time, as the relevant preparation method is mature, the antibacterial liquid dressing product for wounds has good practical value and popularization and application significance.

Description

technical field [0001] This application belongs to the technical field of antibacterial drugs, and specifically relates to a patent application for an antibacterial liquid dressing for wounds and a preparation method thereof. Background technique [0002] In the prior art, Band-Aid is the most widely used and commonly used wound protection product for small-area wounds. Because its ingredients contain certain antibacterial ingredients, it is mainly used to prevent possible infection of the wound. Due to its advantages of small size, simple use, and portability, it is also one of the necessary medical supplies for families. [0003] With the expansion of the scope of use of Band-Aid products, people have found that there are certain limitations in the use of such products. The main manifestations are: the existing conventional Band-Aid products are mainly pasted on the skin surface by medical tape, but the skin of some people is due to I am allergic to the ingredients of the...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0023A61L26/0066A61L2300/204A61L2300/216A61L2300/404C08L1/18
Inventor 杨帅张建鑫袁召曹晶晶王川周新钦
Owner HENAN HUIBO MEDICAL CO LTD
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