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Combination process of nicotinamide riboside and its derivative with pyrroloquinoline quinone and its sodium salt

A technology of nicotinamide ribose and pyrroloquinoline quinone is applied in the field of medicine to achieve the effects of beauty or treatment of diseases and delaying human aging.

Pending Publication Date: 2019-02-19
深圳市龙格生技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no combination of nicotinamide riboside and its derivatives with pyrroloquinoline quinone and its sodium salt in food, beauty products and medicines

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Take two compounds of nicotinamide riboside (NR) (chloride, or nicotinamide riboside) and β-nicotinamide mononucleotide (NMN); or nicotinamide riboside (NR) (chloride, or nicotinamide riboside) Glycoside) and nicotinamide adenine dinucleotide (NADH) two compounds; or nicotinamide ribose (NR) (chloride, or nicotinamide riboside) and pyrroloquinoline quinone disodium salt (PQQ) two compounds or β-nicotinamide mononucleotide (NMN) and nicotinamide adenine dinucleotide (NADH) two compounds; or β-nicotinamide mononucleotide (NMN) and pyrroloquinoline quinone disodium salt ( PQQ) two compounds; or two compounds of nicotinamide adenine dinucleotide (NADH) and pyrroloquinoline quinone disodium salt (PQQ), any two of the above compounds are combined into one formula to make food and health food , beauty products or medicines enter the human body to play a role in the form of external use, oral administration or injection.

[0027] In the above-mentioned embodiments, the dosage ...

Embodiment 2

[0032] Take nicotinamide riboside (NR) (chloride, or nicotinamide riboside), β-nicotinamide mononucleotide (NMN) and nicotinamide adenine dinucleotide (NADH) three compounds; or take nicotinamide Ribose (NR) (chloride, or nicotinamide riboside), β-nicotinamide mononucleotide (NMN) and pyrroloquinoline quinone disodium salt (PQQ) three compounds; or nicotinamide ribose (NR) (chloride, or nicotinamide riboside), nicotinamide adenine dinucleotide (NADH) and pyrroloquinoline quinone disodium salt (PQQ) three compounds; or take β-nicotinamide mononucleotide (NMN ), nicotinamide adenine dinucleotide (NADH) and pyrroloquinoline quinone disodium salt (PQQ); any of the above three different compounds are combined into one formula to make food, health food, beauty product or Drugs, which are used externally, taken orally or injected, enter the human body to play a role;

[0033] In the above-mentioned embodiments, the dosage of nicotinamide riboside (NR) (chloride, or called nicotinami...

Embodiment 3

[0038] Take nicotinamide ribose (NR) (chloride, or nicotinamide riboside), β-nicotinamide mononucleotide (NMN), nicotinamide adenine dinucleotide (NADH) and pyrroloquinoline quinone disodium salt (PQQ) Four different compounds are combined into one formula, made into food, health food, beauty product or medicine, and enter the human body to play a role in the form of external application, oral administration or injection;

[0039] In the above-mentioned embodiments, the dosage of nicotinamide riboside (NR) (chloride, or called nicotinamide riboside) in the combination formula as a single component or the daily dosage range is as follows: a single dosage of 1 mg to 100000 mg, the daily dosage or limited amount 1mg to 100000mg, including applications in food, health products, beauty products and pharmaceuticals.

[0040] In the above-mentioned embodiments, the dose of β-nicotinamide mononucleotide (NMN) in the combination formula is as follows: a single dose of 1 mg to 100000 mg...

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PUM

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Abstract

The invention discloses a combination process of nicotinamide riboside and its derivative with pyrroloquinoline quinone and its sodium salt. The combination process includes: combining any two or three of or all of NR (nicotinamide riboside) (a chloride, or nicotinamide riboside), NMN (beta-nicotinamide mononucleotide), NADH (nicotinamide adenine dinucleotide) and PQQ (pyrroloquinoline quinone disodium salt) into a formulation for making foods, health foods, cosmetics or drugs; the formulation is injected into the human body in external application, oral application or injection manner to takeeffect. The nicotinamide riboside and its derivative function to defy age; the pyrroloquinoline quinone and its sodium salt have the like function and are functionally complementary to nicotinamide riboside; the nicotinamide riboside or its derivative is combined with pyrroloquinoline quinone or its sodium salt into a formulation for making products, such as food additives, health foods, cosmetics and drugs, thereby delaying human senility, maintaining beauty or treating diseases.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a combination process of nicotinamide ribose and its derivatives, pyrroloquinoline quinone and its sodium salt. Background technique [0002] Nicotinamide riboside (NR) (chloride) (English name: nicotinamide riboside, NR for short) is also called nicotinamide riboside, CAS 23111-00-4. Nicotinamide riboside is a kind of vitamin B3 cluster and is the precursor of the important coenzyme nicotinamide adenine dinucleotide. [0003] Nicotinamide adenine dinucleotide (Coenzyme Ⅰ, English: Nicotinamide adenine dinucleotide, abbreviated: NADH). This coenzyme factor is also called "Noga factor" because of the support of six Nobel Prize winners for its related research. It is a coenzyme that transfers protons (more precisely, hydrogen ions), and it participates in the Various physiological activities such as material metabolism, energy synthesis, and cellular DNA repair. Nicotinamide ri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/706A61K31/7084A61K31/4745A61P39/00A23L33/10A61K8/49A61K8/60A61Q19/08
CPCA23L33/10A23V2002/00A61K8/4926A61K8/606A61K31/4745A61K31/706A61K31/7084A61P39/00A61Q19/08A61K2300/00A23V2200/302
Inventor 杨葆生
Owner 深圳市龙格生技术有限公司
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