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Application of diosmetin in preparation of drug for preventing and/or treating hyperuricemic nephropathy

A technology of hyperuricemia and geranialignin, applied in the field of biomedicine, can solve the problems of difficult tolerance of patients, limited clinical use, large toxic and side effects, etc.

Active Publication Date: 2019-03-01
WUHAN POLYTECHNIC UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The present invention aims at the defects of existing medicines for treating hyperuricemia nephropathy with large toxic and side effects, difficult tolerance of patients, and limited clinical use, and aims to develop an anti-hyperuricemia nephropathy medicine with high efficiency and low toxicity, so as to solve the current problems. Toxicity of clinically used drugs, improving patient tolerance and compliance

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  • Application of diosmetin in preparation of drug for preventing and/or treating hyperuricemic nephropathy
  • Application of diosmetin in preparation of drug for preventing and/or treating hyperuricemic nephropathy
  • Application of diosmetin in preparation of drug for preventing and/or treating hyperuricemic nephropathy

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Embodiment Construction

[0019] Preferred embodiments of the present invention will be described in more detail below. Although preferred embodiments of the present invention are described below, it should be understood that the present invention can be embodied in various forms and should not be limited by the embodiments set forth herein.

[0020] The present invention is studied using in vitro and in vivo methods.

[0021] 1. Inhibitory effect of diosmin on xanthine oxidase in vitro

[0022] 1.1 Materials

[0023] 1.1.1 Drugs and reagents

[0024] Diyerin (purity ≥ 97%), batch number D17081604, purchased from Nanjing Dierge Pharmaceutical Technology Co., Ltd.; dipotassium hydrogen phosphate (analytical pure), purchased from Tianjin Tianli Chemical Reagent Co., Ltd.; anhydrous potassium dihydrogen phosphate (analytical Pure), purchased from Guangfu Institute of Fine Chemicals, Tianjin; EDTA-2Na (analytical pure), purchased from Biosharp; xanthine (purity 98%, batch number: D1606030), purchased fr...

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Abstract

The invention belongs to the field of biomedicine, and particularly relates to application of diosmetin in the preparation of a drug for preventing and / or treating hyperuricemic nephropathy. The single use of the diosmetin or the combined use of the diosmetin with allopurinol can significantly reduce serum urea nitrogen and the creatinine level while reducing serum uric acid in mice with the hyperuricemic nephropathy, and can also reduce the increase of the renal index and the spleen index of the mice induced by hyperuricemia, indicating that the combined use of the two drugs can reverse the injury to the renal function of the mice caused by the increase of the serum uric acid while reducing the uric acid of the mice with the hyperuricemic nephropathy to further protect the renal functionof the mice with the hyperuricemic nephropathy and protect an immune system of the mice.

Description

technical field [0001] The present invention belongs to the field of biomedicine, and more specifically relates to the application of diosmin in the preparation of medicines for treating hyperuricemia nephropathy, and the active component is diosmin alone or a drug combination of diosin and allopurinol Combination of diosmin and allopurinol in the preparation of medicine for treating hyperuricemia nephropathy. Background technique [0002] In recent years, with the improvement of people's living standards and changes in dietary structure, the incidence of asymptomatic hyperuricemia and hyperuricemia nephropathy has increased significantly. About 2 / 3 of the uric acid produced by the human body is excreted with the urine through the kidneys. Therefore, hyperuricemia can lead to a decline in renal function. Uric acid nephropathy refers to the short-term deposition of a large number of urate crystals in the renal collecting duct, renal pelvis, and ureter, blocking the renal tub...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61K31/519A61P13/12A61P19/06
CPCA61K31/352A61K31/519A61P13/12A61P19/06A61K2300/00
Inventor 徐凌云刘永杰裴忆雪
Owner WUHAN POLYTECHNIC UNIVERSITY
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