Lactobacillus gasseri and application thereof in preparing premature delivery preventing medicine

Abstract

The invention discloses female vaginal dominant bacteria lactobacillus gasseri H87 and application thereof in preparing a premature delivery preventing medicine, and belongs to the technical field ofmedical microorganisms. The L.gasseri H87 is a novel bacterial genus of a lactobacillus gasseri genus separated from a human body, a repelling effect is avoided, specifically, antibacterial peptide gassericin of the L.gasseri H87 maintains balance of a vaginal flora, and has higher capability of adhering to vaginal epithelial cells, the risk of inflammation of a urogenital region of a patient is reduced, meanwhile, the risk of pregnancy complications of a pregnant woman is reduced, and the strain can be stored for a long term, so that production is facilitated. Lactobacillus gasseri deficiencycan cause a bad pregnancy outcome, such as premature delivery, for the pregnant woman, and a female vaginal microenvironment is reshaped, and therefore the strain can well meet the actual clinical application requirements, and a novel idea is provided for reducing the premature birth rate.

Description

technical field

[0001] The present invention relates to a kind of Lactobacillus gasseri and its application in the preparation of medicines for preventing premature birth, especially a kind of Lactobacillus gasseri (Lactobacillus gasseri) H87, which plays a role in regulating vaginal microenvironment, inhibiting Gardnerella vaginalis (BV pathogenic At the same time, it has the effect of obviously inhibiting Candida and pathogenic bacteria, and has the potential of unique therapeutic advantages for clinical gynecological diseases (preterm birth), and belongs to the field of medical microbiology technology. Background technique

[0002] In 1961, WHO initiated the definition of preterm birth as delivery between 28 weeks of gestation (196d) and 37 weeks of gestation (259d), and the newborn was premature. Preterm birth includes spontaneous premature birth and iatrogenic premature birth caused by mother or fetus (induced labor or cesarean section accounts for about 30%-35%), and s...

Images