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A kind of compound sulfachloropyridazine and preparation method thereof

A technology of sulfachloropyridazine and compound sulfanilamide, which is applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, antibacterial drugs, etc. Excellent effect

Active Publication Date: 2021-03-26
镇江威特药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Purpose of the invention: for the problems referred to above, one of purpose of the present invention is to provide a kind of compound recipe sulfachloropyridazine, to solve the technical problem of poor antibacterial performance

Method used

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  • A kind of compound sulfachloropyridazine and preparation method thereof
  • A kind of compound sulfachloropyridazine and preparation method thereof
  • A kind of compound sulfachloropyridazine and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A compound of compound sulfamine, including the following components: 70g of sulfamidazine, 3.5g of Omegulin, 26.5 g of starch.

[0028] Among them, the mass ratio of sulfamel chloride and Omeglain is 20: 1.

[0029] The preparation method of the compound sulfamel chloride is as follows: the solution of sulfamel chlorozine, Omeanulin and starch are fully mixed according to the amount, and a powder can be obtained from compound sulfamidazine.

Embodiment 2

[0031] A compound of compound sulfamidazine, including the following components: 60g of sulfamidazine, 6g of Omegulin, 34g of starch.

[0032] Among them, the mass ratio of sulfamel chloride and Omegvin is 10: 1.

[0033] The preparation method of the compound sulfamel chloride is as follows: the solution of sulfamel chlorozine, Omeanulin and starch are fully mixed according to the amount, and a powder can be obtained from compound sulfamidazine.

Embodiment 3

[0035] A compound sulfamel chloride comprising the following components: sulfonamazine sodium 30g Omeglain 30g, glucose 40g.

[0036] Among them, the mass ratio of sodium sulfamerazine and Omegvin is 1: 1.

[0037] Preparation of compound sulfamidazine, including the following steps: Compound sulfamidazine can be obtained by mixing sulfamel chlorozine, sulfamel, oxalin and glucose, making a powder according to formulation.

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Abstract

The invention discloses compound sulfachloropyridazine. The compound sulfachloropyridazine is prepared from sulfachloropyridazine or salt thereof and ormetoprim, wherein the mass ratio of the sulfachloropyridazine or the salt thereof to the ormetoprim ranges from (20 to 1) to (1 to 1); the invention further discloses a preparation method of the compound sulfachloropyridazine; the preparation method comprises the following step: sufficiently mixing the sulfachloropyridazine or the salt thereof and the ormetoprim to prepare the compound sulfachloropyridazine. The compound sulfachloropyridazine has the advantages that the ormetoprim is added into the sulfachloropyridazine or the salt thereof, and the ormetoprim is used for inhibiting bacterial dihydrofolate reductase to interfere the synthesis of tetrahydrofolic acid, so as to inhibit the growth of bacteria; the ormetoprim has a relatively strong self bacterium-inhibiting capability, is combined with the sulfachloropyridazine or the saltthereof to have a stronger antibacterial synergistic effect and has a synergistic effect; the ormetoprim more easily penetrates through a tissue barrier and the compound sulfachloropyridazine more easily enters endometrium to express better medicinal performance.

Description

Technical field [0001] The present invention relates to the field of veterinary drugs, in particular to a compound sulfamel chloride and a preparation method thereof. Background technique [0002] Sulfonamide is a common drug for animal disease prevention, and the growth of bacteria is inhibited by inhibiting dihydrofolate synthase. At present, the sulfama drug is often used in combination with a sulfamer synergist such as methoxy, thereby enhancing the sulfamers. The sulfonamine synergents are synthesized by inhibiting bacterial dihydrofolate reductase to interfere with the synthesis of tetrahydrofubic acid, thereby playing efficiency of the drug efficacy of sulfamers. Methoxy is widely used as a conventional sulfonamine synergist, comprising forming a compound formulation with sulfamer, sulfamer sodium sulfamer, sulfamer, sulfamer. With the large number of sulfamine drugs and meta-methoxy, bacteria have begun to occur on the drug resistance of sulfamers, and the methoxymethridi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/635A61K31/505A61P31/04A61P33/00
CPCA61K31/505A61K31/635A61P31/04A61P33/00A61K2300/00
Inventor 戴荣贵黄文江贺文庆
Owner 镇江威特药业有限责任公司
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