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Medical super-hydrophobic antibacterial dressing and method for preparing same

A superhydrophobic and hydrophobic technology, applied in the field of medical products, can solve the problems of bacteria breeding, wound reinfection, patient injury, etc., and achieve the effect of preventing bacterial colonization, enhancing antibacterial ability, and simple operation

Active Publication Date: 2019-03-08
WENZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Gauze is one of the commonly used materials in hospitals. Now hospitals generally use single-layer degreased gauze, which has the following problems: First, according to the traditional weaving method, the stretchability is poor, and the gauze is made of cotton fibers. If it is not replaced for a long time, it is easy to breed bacteria, cause re-infection of the wound, and slow down the healing speed of the wound; secondly, due to the single-layer absorbent cotton structure, it is easy to absorb water when it encounters water. , it is easy to cause wound inflammation, and at the same time, the secretion of the wound sticks to the gauze. It is very easy to breed bacteria, cause wound re-infection, and cause great harm to patients. In modern prevention and treatment technology, silver ions are generally used to achieve the target effect of antibacterial. At the same time, it can promote blood circulation, eliminate or significantly reduce fatigue, and is beneficial to wound healing. Fast healing, but metal ions are generally more toxic to organisms

Method used

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  • Medical super-hydrophobic antibacterial dressing and method for preparing same
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  • Medical super-hydrophobic antibacterial dressing and method for preparing same

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preparation example Construction

[0022] The present invention provides a kind of preparation method of medical superhydrophobic antibacterial dressing, it comprises:

[0023] S1. Put the dressing and dopamine or dopamine salt in a weak alkaline buffer to prepare the first dressing sample modified by polydopamine by self-polymerization of dopamine. That is, through the oxidative polymerization reaction of dopamine under alkaline conditions, a layer of polydopamine film is evenly grown on the limiting surface of the dressing. The polydopamine film has better biocompatibility.

[0024] Among them, the dressing is obtained by weaving or interweaving fibers. For example, the dressing is made of gauze products, cotton products, cloth products or other materials that can be used for medical purposes. Different specifications can be set according to actual conditions. In a preferred embodiment of the present invention, the dressing is selected from medical gauze or medical non-woven fabric, for example, the dressing...

Embodiment 1

[0042] A medical superhydrophobic antibacterial dressing, which includes a dressing and an antibacterial hydrophobic unit, the antibacterial hydrophobic unit is composed of polydopamine modified with fluorine and doped with silver nanoparticles, and the antibacterial hydrophobic unit is attached to the fiber surface of the dressing through the polydopamine.

[0043] Medical superhydrophobic antibacterial dressing is made by following method:

[0044] S1. Soak 50 mg of ordinary medical gauze in 30 ml of Tris buffer solution with a concentration of 10 mM pH=8.5, then add 120 mg of dopamine hydrochloride, and react overnight for 12 hours, so that dopamine spontaneously gathers on the medical gauze to obtain polydopamine polydopamine Modified first dressing sample.

[0045] S2. The first dressing sample was washed 3 times with deionized water to remove excess dopamine, and rinsed with absolute ethanol, then soaked in ethanol at a volume ratio of 1H, 1H, 2H, 2H-perfluorodecanethiol...

Embodiment 2

[0048] A medical superhydrophobic antibacterial dressing, which includes a dressing and an antibacterial hydrophobic unit, the antibacterial hydrophobic unit is composed of polydopamine modified with fluorine and doped with silver nanoparticles, and the antibacterial hydrophobic unit is attached to the fiber surface of the dressing through the polydopamine.

[0049] Medical superhydrophobic antibacterial dressing is made by following method:

[0050] S1. Soak 50 mg of ordinary medical gauze in 30 ml of Tris buffer solution with a concentration of 10 mM and pH=8.5, then add 100 mg of dopamine hydrochloride, and react overnight for 12 hours, so that dopamine spontaneously gathers on the medical gauze to obtain polydopamine polydopamine Modified first dressing sample.

[0051] S2. The first dressing sample was washed 3 times with deionized water to remove excess dopamine, and rinsed with absolute ethanol, then soaked in ethanol at a volume ratio of 1H, 1H, 2H, 2H-perfluorodecanet...

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Abstract

The invention relates to medical super-hydrophobic antibacterial dressing and a method for preparing the same, and relates to the field of medical products. The method for preparing the medical super-hydrophobic antibacterial dressing includes placing dressing in alkaline buffer solution with dopamine and preparing polydopamine-modified first dressing samples by the aid of self-polymerization of the dopamine; placing the first dressing samples in solution with fluorine modifiers, and carrying out reaction to obtain fluorine-embellished polydopamine-modified second dressing samples; placing thesecond dressing samples in silver ionic solution, and carrying out reaction so as to carry out reduction on silver ions on polydopamine to obtain silver nanometer particles. The medical super-hydrophobic antibacterial dressing and the method have the advantages that the medical super-hydrophobic antibacterial dressing can be easily and controllably operated, and the sterilization and anti-adhesion purposes can be achieved by the medical super-hydrophobic antibacterial dressing under the control of the method at different wound healing phases; the medical super-hydrophobic antibacterial dressing is excellent in hydrophobic property and antibacterial property and can be used as acute wound or infected wound dressing.

Description

technical field [0001] The invention relates to the field of medical products, and in particular to a medical superhydrophobic antibacterial dressing and a preparation method thereof. Background technique [0002] Gauze is one of the commonly used materials in hospitals. Now hospitals generally use single-layer degreased gauze, which has the following problems: First, according to the traditional weaving method, the stretchability is poor, and the gauze is made of cotton fibers. If it is not replaced for a long time, it is easy to breed bacteria, cause re-infection of the wound, and slow down the healing speed of the wound; secondly, due to the single-layer absorbent cotton structure, it is easy to absorb water when it encounters water. , it is easy to cause wound inflammation, and at the same time, the secretion of the wound sticks to the gauze. It is very easy to breed bacteria, cause wound re-infection, and cause great harm to patients. In modern prevention and treatment...

Claims

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Application Information

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IPC IPC(8): A61L15/46A61L15/18A61L15/26A61L15/20A61L15/42
CPCA61L15/18A61L15/20A61L15/26A61L15/42A61L15/46A61L2300/104A61L2400/04A61L2400/12A61L2300/404C08L79/02
Inventor 何华成吴疆李圣宇宣暄陈安琪潘跃晓
Owner WENZHOU UNIVERSITY
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