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Degradable magnesium alloy bone nail with scaly bone-like nanostructure coating and preparation method thereof

A nanostructure, magnesium alloy technology, applied in coatings, surface reaction electrolytic coatings, medical preparations containing active ingredients, etc., to achieve the effect of dense coating, high bonding strength, and improved bone formation ability

Active Publication Date: 2021-12-21
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to address the above-mentioned shortcomings of artificial hard tissue substitute materials, and propose a degradable magnesium alloy with a scaly bone-like nanostructure coating on the surface and a preparation method thereof, which can significantly improve the surface biological activity, cell Bone nail with regulating ability and multiple beneficial functions and preparation method thereof by micro-arc oxidation

Method used

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  • Degradable magnesium alloy bone nail with scaly bone-like nanostructure coating and preparation method thereof
  • Degradable magnesium alloy bone nail with scaly bone-like nanostructure coating and preparation method thereof
  • Degradable magnesium alloy bone nail with scaly bone-like nanostructure coating and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0027] (1) First, choose AZ31B magnesium alloy to process the bone nail;

[0028] (2) Bone nail pretreatment: AZ31B magnesium alloy bone nails are polished and polished step by step with metallographic sandpaper with labels of 600#, 800#, and 1000# from coarse sand to fine sand, and then use acetone, 70% alcohol, Ultrasonic cleaning with distilled water and drying for later use.

[0029] (3) Configuration of electrolyte solution: use sodium phosphate solution system, prepare 10L of sodium phosphate solution with a concentration of 5g / L and sodium hydroxide solution with a concentration of 2g / L, for use;

[0030] (4) Micro-arc oxidation of bone nails: place the AZ31B magnesium alloy bone nails in the electrolytic cell of the bipolar pulse micro-arc oxidation equipment and add the prepared electrolyte solution, use the AZ31B magnesium alloy bone screws as the anode, and the stainless steel electrolytic cell as Cathode, adjust process parameters to carry out micro-arc oxidation ...

Embodiment 2

[0035] (1) First, choose AZ31B magnesium alloy to process the bone nail;

[0036] (2) Bone nail pretreatment: AZ31B magnesium alloy bone nails are polished and polished step by step with metallographic sandpaper with labels of 600#, 800#, and 1000# from coarse sand to fine sand, and then use acetone, 70% alcohol, Ultrasonic cleaning with distilled water and drying for later use.

[0037] (3) Configuration of electrolyte solution: use sodium phosphate solution system, configure 10L sodium phosphate solution with a concentration of 10g / L and sodium hydroxide solution with a concentration of 1g / L for use;

[0038] (4) Micro-arc oxidation of bone nails: place the AZ31B magnesium alloy bone nails in the electrolytic cell of the bipolar pulse micro-arc oxidation equipment and add the prepared electrolyte solution, use the AZ31B magnesium alloy bone screws as the anode, and the stainless steel electrolytic cell as Cathode, adjust process parameters to carry out micro-arc oxidation o...

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Abstract

The invention relates to a degradable magnesium alloy bone nail with a scaly bone-like nanostructure coating on the surface and a preparation method thereof. The degradable bone nail consists of an AZ31B magnesium alloy bone nail base and PLGA-bone morphogenetic protein BMP loaded Squamous bone-mimicking nanostructures composed of MgO bioceramic coatings. The magnesium oxide bioceramic coating with a scaly bone-like nanostructure is combined with the surface of a metal substrate, and a nanoscale scaly nanostructure is constructed on the surface of the substrate by a micro-arc oxidation technique. BMP fills and loads between magnesium oxide squamous bone-like nanostructure layers through centrifugal force and capillary action. The preparation method is as follows: firstly, the AZ31B magnesium alloy is processed into a bone nail; then, a magnesium oxide ceramic coating with scaly bone-like nanostructure characteristics is obtained on the surface of the substrate by micro-arc oxidation technology; Loading of PLGA‑bone morphogenetic protein between layers of bone nanostructures.

Description

technical field [0001] The invention relates to a degradable magnesium alloy bone nail with a scaly bone-like nanostructure coating and a preparation method thereof, in particular to a substrate made of an AZ31B magnesium alloy, and a scaly-like bone nail is constructed on its surface by a micro-arc oxidation method. The magnesium oxide bioceramic coating of bone nanostructure, the bone nail loaded with PLGA-bone morphogenetic protein BMP through centrifugal loading technology and the preparation method thereof belong to the technical field of orthopedic implant materials. Background technique [0002] Bone nail is a commonly used orthopedic implant material, and is currently widely used in the treatment of orthopedic diseases. However, commonly used stainless steel and titanium alloy bone nails are not degradable in the human body, causing patients to have to remove the implant after bone tissue regeneration is complete, suffering secondary pain. Absorbable and degradable ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/18A61L31/10A61L31/08A61L31/02A61L31/14A61L31/16C25D11/30
CPCA61L31/022A61L31/088A61L31/10A61L31/14A61L31/148A61L31/16C25D11/026C25D11/30A61L2300/412A61L2300/404A61L2300/252A61L2420/04A61L2420/02A61L2400/12A61L2400/18A61L2300/606A61L2300/602C08L89/00C08L67/04
Inventor 饶席袁伊蝶杨济涵张永平
Owner SOUTHWEST UNIV
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