N-nitrone substituted aryl amide derivative and preparation method thereof

Abstract

The invention relates to an N-nitrone substituted aryl amide derivative and a preparation method thereof. The structural formula of the N-nitrone substituted aryl amide derivative is shown in a formula I. The N-nitrone substituted aryl amide derivative has tert-butyl nitrone group and amide group at adjacent positions on a benzene ring, is an organic synthesis intermediate with wide application, has important application value in the field of pharmaceutical production and organic synthesis, is commonly used for producing vitamins and hormones, and can be used for preparing antibacterial and antimalarial medicines; and meanwhile, the tert-butyl nitrone group has the effect of capturing free radicals, so that the compound can be used for preparing medicines for reducing and preventing damages caused by the free radicals in a biological system, such as medicines with pharmacological effects of resisting platelet aggregation, oxidation, and the free radicals, and reducing blood lipid and the like.

Description

technical field [0001] The invention belongs to the field of aromatic amide derivatives, and in particular relates to an N-nitrone substituted aromatic amide derivative and a preparation method thereof. Background technique [0002] Amide derivatives are an important class of organic synthesis intermediates, which have important application value in the fields of natural product synthesis, chemical industry, medicine, etc., and their synthesis methods have attracted extensive attention from researchers in related fields. The synthesis method of amide derivatives is of great significance. [0003] In the prior art, it is known that aromatic amide derivatives have bactericidal or antimalarial activity. For example, the Chinese patent application with publication number CN106699732A discloses a pyrazole amide derivative and its application as a fungicide. The Chinese patent application with the publication number CN106905247A discloses an acetamide compound, which has an inhi...

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Problems solved by technology

[0007] The object of the present invention is to provide a kind of N-nitrone substituted aromatic amide derivatives, to solve the problem that the active group properties of the existing aromatic amide derivatives are single and the application field is limited

[0008] The second object of the present invention is to provide the preparation method of the above-mentioned N-nitrone substituted aromatic amide derivatives, so as to solve the problems of low reaction efficiency, harsh conditions and small scope of application of substrates in the existing preparation methods

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