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Application of azadirachtin in the preparation of drugs for preventing and treating fungal infections

A technology of azadirachtin and a drug is applied in the directions of an antifungal agent, a pharmaceutical formulation, a medical preparation containing an active ingredient, etc., and can solve the problems of a drug without azadirachtin ringworm, and achieve the desired effect.

Active Publication Date: 2020-11-27
GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there is no relevant report about the application of azadirachtin in the preparation of drugs for preventing and treating pityrosporum folliculitis or ringworm caused by Trichophyton rubrum

Method used

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  • Application of azadirachtin in the preparation of drugs for preventing and treating fungal infections

Examples

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Effect test

Embodiment 1

[0028] (1) Preparation and sterilization of Leeming&Notman medium: weigh 10g of peptone, 5g of glucose, 10g of yeast extract, 1g of glycerin, 0.5g of glyceryl monostearate, 0.5g of Tween-60, 20g of olive oil, and 20g of agar powder , mixed, dissolved in 1000mL of water, stirred until completely dissolved, and then subjected to high temperature and high pressure steam sterilization at a sterilization temperature of 121°C and a sterilization time of 20 minutes.

[0029] (2) Malassezia furfur CMCC(F)Y17 was cultured in a constant temperature incubator at 35°C for 72 hours, then diluted with sterile water to OD 600 =1.0 is prepared as a working solution of bacterial suspension; Trichophyton rubrum CMCC(F)Tla is cultivated in a constant temperature incubator at 30°C for 72h, then diluted to OD with sterile water 600 =1.0 Prepare the working solution of bacterial suspension.

[0030] (3) Take 1 mL of Malassezia furfur CMCC(F)Y17 bacterial suspension onto a sterilized plate with a d...

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Abstract

The invention discloses application of toosendanin in preparation of medicines for preventing and controlling fungus infection, in particular to application of toosendanin in preparation of medicinesfor preventing and controlling tinea symptoms caused by pityros porum folliculitis or trichophyton rubrum. The experiment of the toosendanin pre-adding bacterial liquid pouring plate punching for bacteria inhibiting shows that the application has the advantages that the toosendanin with content of 10.0 mg / g can be used for effectively treating the pityros porum folliculitis infected by malasseziafurfur CMCC(F)Y17, or the hand tinea, foot tinea, head tinea and the like caused by trichophyton rubrum CMCC(F)Tla; the effect is very ideal, the green and environment-friendly effects are realized, and the influence on the health of a human body is avoided.

Description

technical field [0001] The invention relates to the technical field of natural medicines, in particular to the application of azadirachtin in the preparation of medicines for preventing and treating fungal infections. Background technique [0002] In the research of searching for substances with bactericidal and insecticidal activity from natural plants, it has been found that about 1,600 species of plants in the world have excellent bactericidal and insecticidal activities, among which the most studied are plants of the Meliaceae family, mainly neem, neem and neem . This kind of tree is rarely infested with insects. It has a natural bactericidal effect, which not only beautifies the environment, but also has the functions of dust retention, bacteriostasis, and air purification. According to "Compendium of Materia Medica", neem has the effects of clearing away heat and detoxification, removing liver fire, relieving pain, treating hernia, scabies and expelling parasites as m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/58A61P31/10
CPCA61K31/58A61P31/10
Inventor 彭红周刚王颖思谢小保施庆珊李素娟袁英姿
Owner GUANGDONG INST OF MICROBIOLOGY GUANGDONG DETECTION CENT OF MICROBIOLOGY