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Application of mesenchymal stem cells, composition and injection in preparation of diabetes treating drug

A technology of mesenchymal stem cells and composition, applied in the application field of mesenchymal stem cells, can solve the problems of insulin resistance, inability to repair islet function, etc.

Inactive Publication Date: 2019-03-12
CENTURY BIOSTRENGTH BEIJING PTY LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current treatment mainly adopts drug therapy. Although drug therapy can lower blood sugar, it cannot restore the function of pancreatic islets. Treatment with insulin can control symptoms, but long-term use will lead to resistance to insulin.

Method used

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  • Application of mesenchymal stem cells, composition and injection in preparation of diabetes treating drug
  • Application of mesenchymal stem cells, composition and injection in preparation of diabetes treating drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A mesenchymal stem cell, the mesenchymal stem cell is a mesenchymal stem cell obtained after culturing, and the specific method of culturing is as follows: the mesenchymal stem cell is placed under the conditions of 37±0.5°C and 5±0.2% carbon dioxide volume fraction, Add the first culture medium for culture, when the confluence of the cultured cells reaches 85%, add the second culture medium for subculture, and collect the fourth-generation mesenchymal stem cells; the first culture medium consists of DMEM culture fluid and the first additive Composition, the components of the first additive and their concentrations in DMEM culture fluid are 1 μg / mL polyethylene glycol laurate, 3 μg / mL calcium stearoyl lactylate, 5 μg / mL vitamin E, 20 μg / mL sorbic acid Potassium, 1 μg / mL dextran, 6 μg / mL chlorogenic acid, 3 μg / mL Folium Folium water extract and 15 μg / mL Dandelion water extract; Composed of two additives, the total fraction of the fetal bovine serum in the DMEM culture fl...

Embodiment 2

[0028] A mesenchymal stem cell, the mesenchymal stem cell is a mesenchymal stem cell obtained after culturing, and the specific method of culturing is as follows: the mesenchymal stem cell is placed under the conditions of 37±0.5°C and 5±0.2% carbon dioxide volume fraction, Add the first culture medium for culture, when the confluence of the cultured cells reaches 87%, add the second culture medium for subculture, and collect the fourth-generation mesenchymal stem cells; the first culture medium consists of DMEM culture fluid and the first additive Composition, the components of the first additive and their concentrations in DMEM culture fluid are 2 μg / mL polyethylene glycol laurate, 4 μg / mL calcium stearoyl lactylate, 7.5 μg / mL vitamin E, 22 μg / mL sorbic acid Potassium acid potassium, 2 μg / mL dextran, 7 μg / mL chlorogenic acid, 4 μg / mL Folium Folium water extract and 17.5 μg / mL dandelion water extract; and the second additive composition, the total fraction of the fetal bovine...

Embodiment 3

[0030] A mesenchymal stem cell, the mesenchymal stem cell is a mesenchymal stem cell obtained after culturing, and the specific method of culturing is as follows: the mesenchymal stem cell is placed under the conditions of 37±0.5°C and 5±0.2% carbon dioxide volume fraction, Add the first culture medium for culture, when the confluence of the cultured cells reaches 90%, add the second culture medium for subculture, and collect the fourth-generation mesenchymal stem cells; the first culture medium consists of DMEM culture fluid and the first additive Composition, the components of the first additive and their concentration in DMEM culture fluid are 3 μg / mL polyethylene glycol laurate, 5 μg / mL calcium stearoyl lactylate, 10 μg / mL vitamin E, 25 μg / mL sorbic acid Potassium, 3 μg / mL dextran, 8 μg / mL chlorogenic acid, 5 μg / mL Folium Folium water extract and 20 μg / mL Dandelion water extract; Composed of two additives, the total fraction of the fetal bovine serum in the DMEM culture me...

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Abstract

The invention provides application of mesenchymal stem cells, a composition and an injection in preparation of a diabetes treating drug. The mesenchymal stem cells and the composition thereof and theinjection can improve the blood sugar regulating ability of a damaged rat; and after being used with placental hematopoietic stem cells or traditional Chinese medicine extracts, the mesenchymal stem cells and the composition thereof and the injection are more outstanding in blood sugar reducing effect, so that the mesenchymal stem cells and the composition thereof and the injection which are provided by the invention can be used for treating the diabetes.

Description

technical field [0001] The invention belongs to the application field of mesenchymal stem cells, and in particular relates to the application of mesenchymal stem cells, compositions and injections in the preparation of drugs for treating diabetes. Background technique [0002] Diabetes mellitus is a series of clinical syndromes caused by absolute or relative insufficiency of insulin in the body, mainly including type I and type II diabetes. In recent years, the incidence of diabetes is on the rise, and tends to be younger. Diabetes has become a major chronic disease that threatens human health. Different types of diabetes can cause the beta cells in the pancreas to fail to produce enough insulin to lower blood sugar levels, resulting in hyperglycemia. The current treatment method mainly adopts drug therapy. Although drug therapy can lower blood sugar, it cannot repair islet function. Treatment with insulin can control symptoms, but long-term use will lead to resistance to i...

Claims

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Application Information

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IPC IPC(8): A61K35/28A61K36/88A61K9/08A61K47/36A61P3/10C12N5/0775
CPCA61K9/0019A61K9/08A61K35/28A61K36/28A61K36/328A61K36/47A61K36/88A61K47/36A61K2236/15A61K2236/331A61K2236/35A61K2236/51A61P3/10C12N5/0665C12N2500/12C12N2500/30C12N2500/32C12N2500/34C12N2500/38C12N2500/76C12N2501/115A61K2300/00
Inventor 刘世红董明珠潘新卢承前
Owner CENTURY BIOSTRENGTH BEIJING PTY LTD
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