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Heparinoid composition-containing film coating agent

A technology of composition and coating agent, which is applied in the direction of drug combination, medical preparations with non-active ingredients, and non-effective ingredients of polymer compounds, etc. It can solve the problems of imperfect application of heparin-like compositions and achieve the purpose of inhibiting the proliferation of smooth muscle cells , Improve blood circulation and control inflammation

Inactive Publication Date: 2019-03-15
沈阳亿欣源生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, in the prior art, the application of the heparinoid composition on the skin, mucous membrane and other action sites is not perfect.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: A coating agent containing a heparinoid composition, including 30 parts of heparin, 10 parts of polyvinyl alcohol, 1 part of castor oil, 1 part of ethanol, 0.1 part of azone, 0.1 part of vitamin C, and sorbic acid Potassium 0.1 part, glycerin 3 parts, collagen 0.5 part.

Embodiment 2

[0028] Example 2: A coating agent containing a heparinoid composition, including 10 parts of heparin, 20 parts of polyvinyl alcohol, 2 parts of castor oil, 2 parts of ethanol, 1 part of azone, 0.125 parts of vitamin C, and sorbic acid Potassium 0.125 parts, glycerin 10 parts, collagen 5 parts.

Embodiment 3

[0029]Example 3: A film-coating agent containing a heparinoid composition, including 0.5 parts of heparin, 40 parts of polyvinyl alcohol, 5 parts of castor oil, 5 parts of ethanol, 2 parts of azone, 0.2 parts of vitamin C, and sorbic acid Potassium 0.2 parts, glycerin 15 parts, collagen 5 parts.

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PUM

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Abstract

The invention discloses a heparinoid composition-containing film coating agent and belongs to the technical field of biology. The heparinoid composition-containing film coating agent is characterizedby comprising 0.01-30 parts of mucopolysaccharide, 10-90 parts of film forming material, 0.1-5 parts of plasticizer, 0.1-5 parts of volatilizer, 0.01-5 parts of transdermal absorbent, 0.01-5 parts ofantioxidant, 0.01-5 parts of bacteriostatic agent, 0.01-5 parts of surfactant, and 0.1-5 parts of humectant. Under the synergistic effects of a cutin softener and the natural humectant, the excessivegrowth of a collagenous fiber is inhibited, the formation of a scar is alleviated; the moisture on the surface of the skin is retained, the collagenous fiber is softened, the elasticity is strengthened, and the heparinoid composition-containing film coating agent has a softening effect on the hypertrophic scar.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a coating agent containing a heparin-like composition used in medicines, medical equipment, cosmetics, disinfection products and the like. Background technique [0002] Heparinoid is a mucopolysaccharide. In 1948, when Jorpes and Gardell prepared heparin from liver and lung, they obtained a polysaccharide composed of D-glucuronic acid and D-glucosamine. These substances are similar in structure to heparin , but the degree of sulfation is low, and the anticoagulant activity is low, but after more sulfation, its properties change greatly. By combining with the surface of vascular endothelium, it promotes the release of endogenous amino polysaccharides with antithrombotic activity, which can improve local microcirculation, increase blood flow and blood flow velocity, thereby improving intermediate metabolism, promoting skin nutrition supply and waste excretion , play a role...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/727A61K31/737A61K47/32A61K47/36A61K47/38A61K47/42A61P9/14A61P17/02A61P29/00A61P31/02A61P31/04A61P31/10A61P31/14A61P7/10
CPCA61K9/7007A61K31/727A61K31/737A61K47/32A61K47/36A61K47/38A61K47/42A61P7/10A61P9/14A61P17/02A61P29/00A61P31/02A61P31/04A61P31/10A61P31/14
Inventor 唐财坤李丹关云成刘德华满国荣朱凯月肖秀梅马立强
Owner 沈阳亿欣源生物科技有限公司
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