Accurate positioning of nonpalpable focus of subclinical breast cancer by jointly using nuclein and methylene blue

Abstract

The invention discloses accurate positioning of a nonpalpable focus of a subclinical breast cancer by jointly using nuclein and methylene blue. Specifically, low-dosage nuclein and low-volume methylene blue are jointly injected into a focus under stereo positioning, and accordingly the nonpalpable breast focus is accurately positioned and a lump-free breast focus is excised. By adopting the method, on one hand, the body surface position of the focus can be determined under the assistance of a probe, and a surgical separation direction is guided; on the other hand, the low-volume methylene blueplays a visual effect, a surgeon is helped to determine the part and range for surgical excision, and it is ensured that the focus is located at the center of a specimen. Compared with a standard steel wire positioning method, the method is simpler and more convenient and has more superiority on the aspects of decrease of excised tissues and incisal edge positive rate.

Description

technical field [0001] The invention belongs to the technical field of biomedicine. More specifically, it involves radionuclide combined with methylene blue to accurately locate non-palpable lesions of subclinical breast cancer and its resection method. Background technique [0002] Subclinical breast cancer (nonpalpable breast cancer, subclinical breast cancer), also known as preclinical breast cancer, refers to breast cancer that is clinically non-palpable breast mass and detected by imaging examination. With the improvement of breast imaging equipment and technology, and the promotion of breast cancer screening, more and more subclinical breast lesions have been discovered. How to diagnose and treat such breast lesions has become the focus of global breast cancer clinical researchers. Subclinical breast cancer has no clinically palpable breast mass, and most of them belong to BI-RADS category 4 or 5 in imaging examination, and many of these lesions are benign, so it is ...

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Problems solved by technology

However, it also has many disadvantages: (a) the positioning cannot be adjusted in dense glandular tissue, and it is easy to shift in loose adipose tissue; (b) the thin steel wire is easily burned by the electric knife during the operation; (c) High rate of positive margins after surgery; (d) easy to cause discomfort to patients; (e) relatively expensive, etc.

④The localization method of blue dye staining is to inject blue dye into the lesion under stereotaxic, and then the surgeon will excise and biopsy the lesion according to the position and range of the blue dye. However, after the dye is injected, the surgeon still cannot determine the location of the lesion. The projection of the body surface, the surgical incision has a certain degree of blindness

Like the wire localization method, the nuclide is injected into the subclinical lesion under stereotaxic first, and then the body surface projection of the lesion is detected from the body surface with a hand-held γ probe, so the position closest to the lesion can be selected for biopsy incision. The probe can also help to find the position of the lesion in the breast and assist in the resection of the lesion. However, this method cannot directly look at the lesion, making the operation relatively cumbersome, and it is difficult to control the extent of resection, resulting in a high rate of positive margins

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