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Na-K-Mg-Ca glucose injection and preparation method

A technology of glucose injection and glucose, applied in the field of sodium potassium magnesium calcium glucose injection and preparation, can solve the problems that patients are prone to cause acidosis, liver burden and the like, achieve the protection of liver and kidney function, correct acidosis, and simple preparation process. Effect

Inactive Publication Date: 2019-03-22
南京恩泰医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, among the clinical measures for correcting water and electrolyte disorders, sodium lactate Ringer injection is widely used for intravenous injection. However, because sodium lactate Ringer injection contains sodium lactate, sodium lactate needs liver metabolism, which has a greater effect on the liver. Large burden, which is prone to acidosis in patients with liver dysfunction

Method used

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  • Na-K-Mg-Ca glucose injection and preparation method
  • Na-K-Mg-Ca glucose injection and preparation method
  • Na-K-Mg-Ca glucose injection and preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0022] Embodiment 1: the preparation of sodium potassium magnesium calcium glucose injection comprises the following steps:

[0023] S1: Weigh 40% of the total amount of water for injection in the dilute preparation tank, cool down to 70°C-80°C, add 100g of glucose monohydrate, stir to dissolve, and transfer to a constant volume tank;

[0024] S2: Weigh 40% of the total amount of water for injection in the dilute tank, cool down to 50°C-60°C, add 0.876g of sodium chloride, 0.748g of potassium chloride, 0.304g of magnesium chloride hexahydrate, 1.12g of calcium gluconate, Potassium dihydrogen phosphate 1.36g, stir well;

[0025] S3: Add an appropriate amount of citric acid, stir to dissolve, then add 2.72 g of sodium acetate trihydrate, stir to dissolve, transfer to a constant volume tank, and lower the temperature of the constant volume tank to below 50°C;

[0026] S4: Add citric acid to adjust the pH of the solution to 4.7, and add water for injection to 1000 mL;

[0027] S...

Embodiment 2

[0031] Embodiment 2: the preparation of sodium potassium magnesium calcium glucose injection comprises the following steps:

[0032] S1: Weigh 40% of the total amount of water for injection in the dilute preparation tank, cool down to 70°C-80°C, add 100g of glucose monohydrate, stir to dissolve, and transfer to a constant volume tank;

[0033] S2: Weigh 40% of the total amount of water for injection in the dilute tank, cool down to 50°C-60°C, add 0.876g of sodium chloride, 0.748g of potassium chloride, 0.304g of magnesium chloride hexahydrate, 1.12g of calcium gluconate, Potassium dihydrogen phosphate 1.36g, stir well;

[0034] S3: Add an appropriate amount of citric acid, stir to dissolve, then add 2.72 g of sodium acetate trihydrate, stir to dissolve, transfer to a constant volume tank, and lower the temperature of the constant volume tank to below 50°C;

[0035] S4: Add citric acid, adjust the pH value of the solution to 5.3, and add water for injection to 1000 mL;

[003...

Embodiment 3

[0040] Embodiment 3: the preparation of sodium potassium magnesium calcium glucose injection comprises the following steps:

[0041] S1: Weigh 40% of the total amount of water for injection in the dilute preparation tank, cool down to 70°C-80°C, add 100g of glucose monohydrate, stir to dissolve, and transfer to a constant volume tank;

[0042] S2: Weigh 40% of the total amount of water for injection in the dilute tank, cool down to 50°C-60°C, add 0.876g of sodium chloride, 0.748g of potassium chloride, 0.304g of magnesium chloride hexahydrate, 1.12g of calcium gluconate, Potassium dihydrogen phosphate 1.36g, stir well;

[0043] S3: Add an appropriate amount of citric acid, stir to dissolve, then add 2.72 g of sodium acetate trihydrate, stir to dissolve, transfer to a constant volume tank, and lower the temperature of the constant volume tank to below 50°C;

[0044] S4: Add citric acid, adjust the pH value of the solution to 5.0, and replenish water for injection to 1000 mL; ...

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Abstract

The invention discloses Na-K-Mg-Ca glucose injection. The Na-K-Mg-Ca glucose injection is prepared from the following components as shown in the description. The Na-K-Mg-Ca glucose injection is used for supplementing water and maintaining in-vivo electrolyte balance, is capable of effectively correcting acidosis, and is beneficial for protecting the hepatic and renal functions. The invention alsoprovides a preparation method of the Na-K-Mg-Ca glucose injection. The preparation method provided by the invention is simple in technology, and is capable of effectively controlling the content of 5-hydroxyl furfuraldehyde in a product.

Description

technical field [0001] The invention relates to a sodium-potassium-magnesium-calcium-glucose injection and a preparation method thereof, belonging to the technical field of injection supplements. Background technique [0002] Water and electrolyte disorders are very common in clinical practice, such as diarrhea, vomiting, burns, renal insufficiency, etc. can lead to dehydration and electrolyte disorders in the human body. If it is not corrected in time, water and electrolyte disorders can lead to corresponding disorders in the physiological functions of various organ systems and the body's substance metabolism, especially in the cardiovascular system and nervous system. Severe water and electrolyte disturbances can even lead to death. Therefore, it is necessary to pay attention to the disturbance of water and electrolyte. [0003] At present, among the clinical measures for correcting water and electrolyte disorders, sodium lactate Ringer's injection is widely used for int...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/42A61K9/08A61P3/12A61P39/02A61P1/16A61P13/12A61K33/14A61K33/06A61K31/7004A61K31/191A61K31/19
CPCA61K9/0019A61K9/08A61K31/19A61K31/191A61K31/7004A61K33/06A61K33/14A61K33/42A61P1/16A61P3/12A61P13/12A61P39/02A61K2300/00
Inventor 朱垒垒夏季红孙磊董萱
Owner 南京恩泰医药科技有限公司
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