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Icotinib-containing external use drug compound for skin and application thereof

The technology of an external drug, Icotinib, is applied in the field of skin topical pharmaceutical composition

Inactive Publication Date: 2019-03-26
BETTA PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are currently no established psoriasis drugs on the market that use tyrosine kinase inhibitors

Method used

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  • Icotinib-containing external use drug compound for skin and application thereof
  • Icotinib-containing external use drug compound for skin and application thereof
  • Icotinib-containing external use drug compound for skin and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-10

[0086] 1. Formulation (see Table 1)

[0087] Table 1

[0088]

[0089] 2. the preparation method of embodiment 1-10

[0090] (1) take the carbomer of recipe quantity, swell completely in propylene glycol;

[0091] (2) Weigh the Icotinib hydrochloride, Transcutol P and / or Labrasol of the prescribed amount respectively, and mix them uniformly;

[0092] (3) adding the mixture obtained in step (2) to the swollen carbomer solution obtained in step (1);

[0093] (4) Stir the mixture obtained in step (3) at room temperature until transparent.

Embodiment 11-14

[0095] 1. Formulation (see Table 2)

[0096] Table 2

[0097]

[0098] 2. The preparation method of embodiment 11-14

[0099] (1) Take respectively Icotinib hydrochloride, Transcutol P and Labrasol of prescription quantity, mix homogeneously;

[0100] (2) the mixture obtained in step (1) is added in the propylene glycol solution;

[0101] (3) Stir the mixture obtained in step (2) at room temperature until transparent.

Embodiment 15-20

[0103] 1. Formulation (see Table 3)

[0104] table 3

[0105]

[0106] 2. The preparation method of embodiment 15-20

[0107] (1) Carbomer and ethylparaben that take prescription quantity respectively, swell completely in propylene glycol;

[0108] (2) Take respectively Icotinib hydrochloride, Transcutol P and Labrasol of prescription quantity, mix homogeneously;

[0109] (3) adding the mixture obtained in step (2) to the swelled carbomer solution obtained in step (1);

[0110] (4) Stir the mixture obtained in step (3) at room temperature until it becomes transparent.

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PUM

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Abstract

The invention relates to an external use preparation for restraining tyrosine kinase and a preparation method thereof and especially relates to an external use drug compound for restraining tyrosine kinase and the preparation method thereof. Icotinib or a pharmacologically acceptable salt thereof is taken as an active ingredient of the external use preparation provided by the invention. The preparation is suitable for local application, has little skin irritation and has no adverse reaction, such as pruritus, burning sensation, pricking, dry skin, erythema and rash; no parahormone side effect,such as adermotrophia, chromatosis or lysis, occurs after long-term use of the preparation; no related dermatologic symptom occurs after drug withdrawal. The preparation method has the advantages ofsimple and easy operation and control, easiness in industrialization, and the like.

Description

[0001] This application is a divisional application of an application with an application date of October 11, 2014, an application number of 201480001225.7, and an invention title of "a pharmaceutical composition for external use containing icotinib and its application". technical field [0002] The invention relates to a skin external pharmaceutical composition containing icotinib or a pharmaceutically acceptable salt thereof and application thereof. Background technique [0003] Dermatosis is a disease related to the skin, and is one of common diseases and frequently-occurring diseases that seriously affect people's health, such as leprosy, scabies, fungal diseases, psoriasis, skin bacterial infections, etc. Dermatosis is the skin (including hair and nails) affected by internal and external factors, its shape, structure and function all change, resulting in pathological process, and correspondingly produce various clinical manifestations. The incidence of skin diseases is ...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/32A61K47/14A61K47/10A61K31/519A61P35/00A61P17/00A61P17/06
Inventor 王印祥袁树军王燕萍胡邵京胡云雁
Owner BETTA PHARM CO LTD
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