Ultra-slippery antibacterial material, preparation method thereof and ultra-slippery antibacterial guide pipe

A technology of antibacterial materials and antibacterial layers, applied in the direction of coating, etc., can solve the problems of cell or tissue biotoxicity, promote bacterial drug resistance, etc., achieve the effect of reducing initial adhesion, good sterilization and antibacterial, and improving lubrication performance

Active Publication Date: 2019-03-26
WEIGAO HLDG +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the common antibacterial method on the surface of the catheter is to physically coat the antibacterial agent on the surface. The antibacterial agent released can effectively kill bacteria, but it also has certain biological toxicity to surrounding normal cells or tissues.
In addition, the low-concentration environment of antibacterial agents due to the decline in reserves will promote the emergence of bacterial resistance

Method used

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  • Ultra-slippery antibacterial material, preparation method thereof and ultra-slippery antibacterial guide pipe
  • Ultra-slippery antibacterial material, preparation method thereof and ultra-slippery antibacterial guide pipe
  • Ultra-slippery antibacterial material, preparation method thereof and ultra-slippery antibacterial guide pipe

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preparation example Construction

[0080] The present invention also provides a kind of preparation method of super slippery antibacterial material, comprises the following steps:

[0081] a) providing a solution of a crosslinkable random copolymer, the crosslinkable random copolymer comprising a structure shown in formula (I);

[0082] b) attaching the solution of the cross-linkable random copolymer to the surface of the substrate, and irradiating with ultraviolet light, forming a cross-linked network structure antibacterial layer on the surface of the substrate;

[0083] c) Infiltrating the antibacterial layer with cross-linked network structure with lubricating oil to obtain a super slippery antibacterial material.

[0084] In the preparation method provided by the present invention, firstly, a solution of crosslinkable random copolymer is provided. Wherein, the solution of the crosslinkable random copolymer is composed of a crosslinkable random copolymer and a solvent, and the specific structure of the cro...

Embodiment 1

[0106] 1) Synthesis of crosslinkable random copolymers:

[0107] Add 1.6 mg of initiator azobisisobutyronitrile, 1.57 g of dimethylaminoethyl methacrylate, 10.81 g of trifluorooctyl methacrylate, and 35 mL of toluene as a solvent into the three-necked flask. The air in the bottle was purged with nitrogen for 10 min. The reaction was protected with nitrogen, sealed, and stirred and refluxed at 50°C for 24h. After the mixture was cooled to room temperature, cold ethanol was added until the precipitation of the copolymer was complete. Filter and dry in vacuo to obtain poly(dimethylaminoethyl methacrylate-co-tridecafluorooctyl methacrylate) copolymer. The above copolymer was dissolved in 30 mL of toluene, 1.44 g of dodecane chloride and 0.83 g of 3-(bromomethyl)benzophenone were added, and the mixture was reacted at 60° C. for 24 h. After the reaction was completed, rotary evaporation and vacuum drying gave a light yellow solid. After dissolving the light yellow solid with a l...

Embodiment 2

[0115] 1) Synthesis of crosslinkable random copolymers:

[0116] Add 2.0 mg of initiator azobisisobutyronitrile, 0.57 g of dimethylaminoethyl acrylate, 8.64 g of 2-(perfluorohexyl) ethyl methacrylate, and 20 mL of toluene into the three-necked flask. The air in the bottle was purged with nitrogen for 10 min. The reaction was protected with nitrogen, sealed, and stirred and refluxed at 60°C for 18h. After the mixture was cooled to room temperature, cold ethanol was added until the precipitation of the copolymer was complete. Filter and dry in vacuum to obtain poly(dimethylaminoethyl acrylate-co-2-(perfluorohexyl)ethyl methacrylate) copolymer. The above copolymer was dissolved in 15 mL of toluene, 0.54 g of chloro-n-octane and 0.12 g of 2-bromomethylanthraquinone were added, and the reaction was carried out at 60° C. for 24 h. After the reaction was completed, rotary evaporation and vacuum drying gave a light yellow solid. After dissolving the light yellow solid with a large...

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Abstract

The invention relates to the field of medical instruments and particularly relates to an ultra-slippery antibacterial material, a preparation method thereof and an ultra-slippery antibacterial guide pipe. A pipe body material of the guide pipe is a self-researched and self-developed ultra-slippery antibacterial material. The ultra-slippery antibacterial material comprises a base material, a cross-linking network-structure antibacterial layer and lubricating oil, wherein the cross-linking network-structure antibacterial layer is cross-linked and grafted to the surface of the base material; thelubricating oil, is fixed on the cross-linking network-structure antibacterial layer; and the cross-linking network-structure antibacterial layer is formed by carrying out ultraviolet radiation on a cross-linkable random copolymer, and the cross-linkable random copolymer has a structure represented by a formula (I) (shown in the description). The self-researched and self-developed ultra-slippery antibacterial material is taken as the pipe body material of the guide pipe, so that the guide pipe has good lubricating property and antibacterial property; and the antibacterial components in the guide pipe are in a non-release type, so that the risk caused due to the effusion of the antibacterial components can be avoided, and the safety is relatively high.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a super-smooth antibacterial material, a preparation method thereof, and a super-smooth antibacterial catheter. Background technique [0002] With the development of catheter diagnosis and treatment technology, the demand for medical catheters in clinical practice continues to increase, and nearly ten million cases are used every year. According to statistics, there are nearly 120 kinds of catheters in six categories used in urology in the world, and there are more than 100 kinds of catheters used in the diagnosis and treatment of diseases such as cerebrovascular, cardiovascular, and tumors. Statistics show that the annual global output value of medical catheters exceeds 5 billion US dollars. [0003] During the storage and intervention of medical catheters into the human body, bacteria tend to adhere to the surface of the catheter, and quickly proliferate bacterial biofilms, whic...

Claims

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Application Information

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IPC IPC(8): C08J7/04C08J7/12C08L75/04C08L27/06C09D133/16
CPCC08J7/123C08J2327/06C08J2375/04C08J2433/16C08J7/0427
Inventor 闫顺杰栾世方殷敬华周容涛吴刚陈家悦宋超朱雪真
Owner WEIGAO HLDG
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