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Method for surface enhanced Raman scattering detection

A surface-enhanced Raman and solution technology, applied in Raman scattering, material analysis by optical means, measurement devices, etc., can solve problems such as low hot spot density, poor stability, and difficulty in obtaining highly sensitive and repeatable SERS detection , to achieve high-efficiency Raman scattering signals and avoid direct contact

Active Publication Date: 2019-03-26
CAPITAL NORMAL UNIVERSITY
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Problems solved by technology

[0005] The existing SERS substrates provide low hotspot density and poor stability, making it difficult to obtain highly sensitive and reproducible SERS detection

Method used

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  • Method for surface enhanced Raman scattering detection
  • Method for surface enhanced Raman scattering detection

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Embodiment Construction

[0042] In the drawings, the same or similar reference numerals are used to denote the same or similar elements or elements having the same or similar functions. Embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0043] In the description of the present invention, the terms "central", "longitudinal", "transverse", "front", "rear", "left", "right", "vertical", "horizontal", "top", " The orientation or positional relationship indicated by "bottom", "inner", "outer", etc. is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying the referred device or element Must have a specific orientation, be constructed and operate in a specific orientation, and therefore should not be construed as limiting the scope of the invention.

[0044] figure 1 It is a flowchart ...

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Abstract

The embodiment of the invention discloses a method for surface enhanced Raman scattering detection. The method comprises the following step: preparing core-shell structures of silver core silicon dioxide shells deposited in a nano pore array on an AAO template. When the silver core silicon dioxide shells are taken as a substrate for surface enhanced Raman spectra, the core-shell structures form octahedral interstices, tetrahedral interstices or other irregular interstices like crystal structures in the stacking process. The interstices can form attachment points of probe molecules. As pore wall of the nano pore array on the AAO template is transparent and the shells of the core-shell structures are transparent, incident Raman detection laser can be directly focused to inner cores of the core-shell structures near the probe molecules to enhance the Raman scattering signals of the probe molecules, so that efficient surface enhanced Raman scattering signals are acquired.

Description

technical field [0001] The invention relates to the technical field of surface-enhanced Raman spectroscopy, in particular to a method for performing surface-enhanced Raman scattering detection. Background technique [0002] The Raman scattering phenomenon was first observed experimentally by the Indian physicist Raman (Raman). It is an inelastic scattering phenomenon that occurs when light is irradiated on atoms or molecules, that is, the scattered light has a frequency different from that of the incident light. Light. Raman spectroscopy carries the "fingerprint" information of substances, which provides an effective means for studying the internal structure of crystals and molecules, so Raman spectroscopy is widely used in substance detection. [0003] However, the Raman scattering cross-section of molecules is usually very small, and only a large number of molecules can contribute a measurable Raman signal, which makes it a great limitation as a spectral detection techniq...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 张利胜祁幸男曾卓王培杰李志鹏方炎
Owner CAPITAL NORMAL UNIVERSITY
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