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Inosine injection and preparation method thereof

A technique for inosine injection and injection, which is applied in the field of inosine injection and its preparation, can solve problems such as unstable properties of inosine injection, and achieve the effects of avoiding adverse effects, stable performance, and avoiding yellowing of color and luster.

Active Publication Date: 2021-09-24
江西诺立医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to provide a kind of inosine injection and preparation method thereof in order to overcome the unstable property of inosine injection existing in the prior art, this inosine injection has stable property, easy storage, long storage period advantage

Method used

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  • Inosine injection and preparation method thereof
  • Inosine injection and preparation method thereof
  • Inosine injection and preparation method thereof

Examples

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Effect test

Embodiment 1

[0040] This example is used to illustrate the inosine injection of the present invention and its preparation method.

[0041] Accurately take the raw materials and auxiliary materials of each formulation amount with 1000L injection as the unit: inosine 5.9kg, sodium chloride 9.2kg, glycine 1kg, sodium benzoate 1.5kg, prepare this inosine injection by the following method:

[0042] (1) prepare the sodium hydroxide aqueous solution that pH value is 9.0;

[0043] (2) Add inosine to the aqueous sodium hydroxide solution, heat and stir until the inosine is dissolved, and obtain an aqueous solution of inosine;

[0044] (3) add sodium chloride after the inosine aqueous solution is incubated at 75° C. for 40 min, and then add glucosine and sodium benzoate to dissolve after the sodium chloride dissolves;

[0045] (4) Add 1 kg of activated carbon to the above solution, filter after stirring, add water for injection to dilute to 960L;

[0046] (5) Adjust the pH of the solution obtained...

Embodiment 2

[0051] This example is used to illustrate the inosine injection of the present invention and its preparation method.

[0052] Accurately weigh the raw materials and auxiliary materials of each formulation amount in units of 1000L injection: inosine 6.1kg, sodium chloride 8.8kg, glycine 1.2kg, sodium benzoate 0.5kg. Prepare this inosine injection according to the following method:

[0053] (1) prepare the sodium hydroxide aqueous solution that pH value is 9.5;

[0054] (2) Add inosine to the aqueous sodium hydroxide solution, heat and stir until the inosine is dissolved, and obtain an aqueous solution of inosine;

[0055] (3) add sodium chloride after the inosine aqueous solution is incubated at 85° C. for 20 minutes, and then add glucosine and sodium benzoate to dissolve after the sodium chloride dissolves;

[0056] (4) Add 1.2kg of activated carbon to the above solution, filter after stirring, add water for injection to dilute to 980L;

[0057] (5) Adjust the pH of the sol...

Embodiment 3

[0062] This example is used to illustrate the inosine injection of the present invention and its preparation method.

[0063] Accurately take by weighing the raw materials and auxiliary materials of each formulation amount with 1000L injection as the unit: inosine 6kg, sodium chloride 9kg, glycine 1.1kg, sodium benzoate 0.61kg. Prepare this inosine injection according to the following method:

[0064] (1) prepare the sodium hydroxide aqueous solution that pH value is 9.2;

[0065] (2) Add inosine to the aqueous sodium hydroxide solution, heat and stir until the inosine is dissolved, and obtain an aqueous solution of inosine;

[0066] (3) add sodium chloride after the inosine aqueous solution is incubated at 80° C. for 30 minutes, and then add glucosine and sodium benzoate to dissolve after the sodium chloride dissolves;

[0067] (4) Add 1.5kg of activated carbon to the above solution, filter after stirring, add water for injection to dilute, and dilute to 970L;

[0068] (5)...

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Abstract

The invention relates to the technical field of medical injections, and discloses an inosine injection and a preparation method thereof, wherein, every 100mL of the injection contains: 0.58-0.62g of inosine, 0.85-0.95g of sodium chloride, glycosine 0.08‑0.12g and sodium benzoate 0.05‑0.5g. The method for preparing the injection comprises: adding inosine to an aqueous solution of sodium hydroxide to obtain an aqueous solution of inosine; mixing the aqueous solution of inosine with sodium chloride, glucosine and sodium benzoate; adding activated carbon, filtering after stirring, and injecting Dilute with water; adjust pH of solution to 7‑8. In the present invention, by adding a small amount of glucosine and sodium benzoate as auxiliary agents in the inosine injection, the phenomenon of yellowing of the injection is avoided, and the performance of the injection is more stable; in addition, the present invention also maximizes the The adverse effect of the auxiliary agent on the active ingredients of the injection is avoided.

Description

technical field [0001] The invention relates to the technical field of medical injections, in particular to an inosine injection and a preparation method thereof. Background technique [0002] Inosine (Inoside) is also called hypoxanthine nucleoside. Because it can participate in energy metabolism and protein synthesis in the body, activate pyruvate oxidase, make cells continue to metabolize under hypoxic conditions, and promote rapid repair of damaged liver cells and cardiomyocytes, so it is widely used in clinical practice. It is mainly used for white blood cell and thrombocytopenia, various acute and chronic hepatitis, heart disease, central retinitis, and optic atrophy. In recent years, it has also been used in the treatment of psoriasis and flat warts in dermatology. It can also be used to prevent and relieve heart and liver toxicity caused by dysprosium poisoning and other drug poisoning. [0003] Inosine Sodium Chloride Injection has been included in the Chinese Ph...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K47/18A61K47/12A61K31/7076A61P7/00A61P1/16A61P9/00A61P9/10A61P17/12A61P17/06
CPCA61K9/0019A61K9/08A61K31/7076A61K47/12A61K47/183A61P1/16A61P7/00A61P9/00A61P9/10A61P17/06A61P17/12
Inventor 廖年生邹明明徐盼李海荣
Owner 江西诺立医药科技有限公司
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