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An ionization device and its application

A technology of ionization and atomization gas, which is applied in the direction of measuring devices, ion sources/guns, particle separation tubes, etc., can solve the problems of increasing the manufacturing cost of instruments, the complexity of detection, and the inability to meet the detection requirements

Active Publication Date: 2020-02-14
BEIJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When dealing with complex samples, the use of a single ion source cannot meet the detection requirements for a variety of molecules with different characteristics in complex samples. Usually, multiple ion sources are used in combination to achieve the detection purpose, which increases the manufacturing cost and detection complexity of the instrument.

Method used

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  • An ionization device and its application
  • An ionization device and its application
  • An ionization device and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1, ionization device

[0056] Such as figure 1 Shown is a schematic structural view of the ionization device of the present invention. It includes a sample capillary 1, an atomizing gas capillary 3, a drying gas tube 7, two copper ring electrodes (copper ring electrode a 8 and copper ring electrode b 9) and an AC high voltage power supply. The sample capillary 1 (specifically, it can be made of quartz), the atomizing gas capillary 3 (specifically, it can be made of quartz), and the drying gas tube 7 (specifically, it can be made of glass or quartz) are arranged in sequence from inside to outside on the same axis. And 2 copper ring electrodes, and the copper ring electrode a 8 and the copper ring electrode b 9 are both sleeved on the dry gas pipe.

[0057] One end of the sample capillary 1 is set as a direct sampling interface, and the other end is set as a sample outlet; the section of the sample capillary 1 near the direct sampling interface and the atomiz...

Embodiment 2

[0072] Example 2, signal acquisition of substances with different molecular weights and polarities

[0073] Weigh 2.0 mg of myosin (from horse skeletal muscle), 2.0 mg of cytochrome C (from horse heart), 10 mg of berberine hydrochloride, and 10 mg of biphenyl, each containing 10% (V / V) methanol, 1‰ (V / V) formic acid in water was prepared as a 10mL solution.

[0074] Dissolve 1 mg of dynorphin A (fragments 1-13) in the package with 1 mL of ultrapure water. Take 32 μL of this solution and prepare a 10 mL solution with water containing 10% (V / V) methanol and 1‰ (V / V) formic acid.

[0075] The mass spectrometer using the ionization device in Example 1 of the present invention is set to positive ion full-scan mode, the mass-to-charge ratio range is 200-4000; the capillary temperature is set to 200°C, and the voltage is 50V; the Tube Lens voltage is set to 250V . After turning on the two channels of nitrogen, use the syringe pump to increase the concentration by 50 μL·min from lo...

Embodiment 3

[0076] Embodiment 3, the adjustment effect of ionization power on signal

[0077] Weigh 0.10 g of penicillin G sodium salt powder and dissolve it in 10 mL of methanol water (10% methanol content, the same below) to prepare penicillin G sodium salt solution. After turning on the nitrogen gas, start the syringe pump with a flow rate of 50 μL·min-1. The mass spectrometer using the ionization device in Example 1 of the present invention is set to a positive ion full-scan mode, with a mass-to-charge ratio range of 200-4000. Capillary temperature Capillary temperature is set to 200 ℃, voltage 50V. Tube Lens voltage is set to 250V.

[0078] Adjust the output power of the voltage regulator to 0W, 3.0W, 20W, 38W, 48W. collect the signals separately image 3 The signal shown indicates that the device of the present invention can manipulate the aggregation state of molecules by adjusting the power.

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Abstract

The invention discloses an ionization device and an application thereof. The ionization device comprises a sample capillary tube, an atomizing gas capillary tube, a drying gas tube and two copper ringelectrodes, and an alternating-current high-voltage power supply which are sequentially arranged from inside to outside by adopting the same axis, wherein the two copper ring electrodes are arrangedon the drying gas tube in a sleeved mode; the sample capillary tube and the atomizing gas capillary tube are connected with an atomizing gas tube through a T-shaped tee joint a; the sample capillary tube, the atomizing gas capillary tube and the drying gas tube are connected with a dry gas injection tube through a T-shaped tee joint b; an ionized high-voltage interface connected with a high-voltage output electrode of the alternating-current high-voltage power supply is arranged in one copper ring electrode; a ground wire interface connected with a ground wire is arranged in the other copper ring electrode; and the ground wire is connected with the ground wire of the ionized high-voltage alternating-current power supply and is grounded. According to the ionization device, rapid detection of molecules with different polarities and different sizes can be realized, and a quasi-molecular ion peak is obtained; fragment information is obtained through tuning; and the ionization device is simple in structure, easy to assemble and maintain and capable of being manufactured in a highly integrated mode.

Description

technical field [0001] The invention relates to an ionization device and its application, belonging to the field of organic spectrum analysis. Background technique [0002] Mass spectrometry is a means of ionizing substances and characterizing them by determining the mass-to-charge ratio of the ions. Since most macroscopic substances are electrically neutral or nearly electrically neutral, the sample needs to be ionized before entering the mass spectrometer for detection, so the ion source becomes an important part of the mass spectrometer. In recent years, atmospheric pressure mass spectrometry has developed rapidly, providing a powerful tool for quickly obtaining sample information without sample pretreatment. In the ionization technology of atmospheric pressure mass spectrometry, it is mainly divided into electrospray technology and atmospheric pressure chemical ionization technology. These two techniques are suitable for the ionization detection of highly polar molecul...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01J49/10H01J49/14H01J49/16G01N27/62
CPCG01N27/622H01J49/107H01J49/145H01J49/167
Inventor 那娜王岩欧阳津
Owner BEIJING NORMAL UNIVERSITY
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