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Preparation for treating sore mouth disease and preparation method thereof

A kind of oral ulcer and preparation technology, which is applied in the field of preparation for treating oral ulcer and its preparation, and can solve the problems of limited therapeutic effect, poor selectivity and specificity of transdermal agents, and not very wide range of application.

Active Publication Date: 2019-04-05
绿亚生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Transdermal administration has a long history in traditional Chinese medicine in my country. Traditional lotions, liniments, pastes, and ointments in China belong to the category of transdermal agents. However, due to the limitations of related technologies, traditional transdermal agents are selective and The specificity is poor, the transdermal rate and transdermal rate of the drug are relatively low, the therapeutic effect is limited, and long-term medication and repeated medication are often required, so the scope of application is not very wide

Method used

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  • Preparation for treating sore mouth disease and preparation method thereof
  • Preparation for treating sore mouth disease and preparation method thereof
  • Preparation for treating sore mouth disease and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The following examples facilitate a better understanding of the present invention, but do not limit the present invention. The experimental methods in the following examples are conventional methods unless otherwise specified. The test materials used in the following examples are commercially available unless otherwise specified. Embodiment 1 Molecular distillation method extracts garlic essential oil

[0023] Molecular distillation is a special liquid-liquid separation technology. It is different from traditional distillation which relies on the separation principle of boiling point difference, but relies on the difference in the mean free path of molecular motion of different substances to achieve separation. When the liquid mixture flows along the heating plate and is heated, the light and heavy molecules will escape from the liquid surface and enter the gas phase. Since the free paths of the light and heavy molecules are different, the molecules of different substa...

Embodiment 2

[0039] Glycyrrhizin is the main active ingredient in licorice, which can inhibit hepatitis virus, etc.; garlic essential oil is composed of a variety of volatile substances, which can be antibacterial and virus; tea tree oil is highly volatile and permeable, and can be antibacterial and virus. The present invention finds that these three active ingredients are used to prepare a preparation for treating aphthous ulcers, which has achieved very good results, and no relevant research has been reported.

[0040] 1. Experimental part

[0041] 1.1 See Table 2 for approvals and manufacturers of excipients.

[0042] Table 2 Excipient approval and manufacturer

[0043]

[0044] 1.2 Prescription Composition

[0045]According to the antiviral activity of glycyrrhizin, together with garlic essential oil and tea tree essential oil as activity enhancers, skin penetration and other characteristics, the present invention selects glycyrrhizin, garlic essential oil and tea tree essential o...

Embodiment 3

[0081] Clinical efficacy test of embodiment 3 aphthous ulcer preparation

[0082] Sheep oral ulcer, also known as sheep contagious pustular or sheep contagious pustular dermatitis, is an acute contact infectious disease caused by contact with contagious pustular dermatitis virus in sheep, characterized by oral mucosa, lips, face, legs and Papules, pustules, ulcers, and thick, warty scabs form on the skin of the breasts. In recent years, the inventors of the present application have used glycyrrhizin, tea tree essential oil and garlic essential oil to prepare new preparations for treating aphthous ulcers, all of which have achieved significant curative effects. In order to further determine the optimum therapeutic concentration and clinical efficacy of the preparation, this experiment was carried out.

[0083] 1 Materials and methods

[0084] 1.1 Materials

[0085] 1.1.1 Source of Drugs Oral ulcer preparation No. 2 prepared in Example 2 (that is, a prescription containing 2 p...

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Abstract

The invention provides a preparation for treating a sore mouth disease. The preparation is characterized by being prepared from the following components in parts by mass: 0 to 4 parts of glycyrrhizin,0 to 4 parts of garlic essential oil and 0 to 4 parts of tea tree essential oil, wherein the total amount of the three components is 6 parts by mass. The invention further provides a preparation method of the preparation. The glycyrrhizin is a main effective component in liquorice root; the garlic essential oil is separated from garlic and consists of various volatile matters; the tea tree essential oil is obtained by distilling whole tea tree plants through water steam and has strong volatility and permeability; the three active components respectively have antibacterial and anti-virus activity; however, the activity does not become stronger certainly when compounds with activity are combined together. A novel preparation for treating the sore mouth disease is prepared through scientificcombination on the basis of a lot of tests; a very good clinical utilization effect is obtained and related researches are not reported.

Description

technical field [0001] The invention belongs to the technical field of veterinary medicine, and in particular relates to a preparation for treating aphthous ulcer and a preparation method thereof. Background technique [0002] An epitheliophilic infectious disease caused by aphthous aphthus is called aphthous aphthous disease, which can affect both humans and animals. Its onset is characterized by the formation of blisters on the mouth, lips, tongue, nose, palate, etc. , pustules, and verrucous scabs. Oral aphthous disease often occurs in spring and autumn, and young lambs are most likely to develop the disease. Although the mortality rate of aphthous oral canal disease is not high, the speed of transmission and infection is fast. If the disease is severe, it will cause serious diseases such as secondary pneumonia, so it is still necessary in the breeding industry. attention. [0003] Glycyrrhizin preparations were originally used in the treatment of skin diseases, and the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8962A61K9/00A61K47/10A61P31/02A61P31/04A61P31/20A61K31/704
CPCA61K9/0014A61K9/006A61K31/704A61K36/61A61K36/8962A61K47/10A61K2236/331A61K2236/37A61P31/02A61P31/04A61P31/20A61K2300/00
Inventor 梁剑平刘宇梁妍党岩郝宝成王学红尚若锋赵凤舞于鹏贾忠郭建钊刘建枝王保海王震
Owner 绿亚生物科技有限公司