Method for constructing 6-(3-fluorophenyl)indolo[1,2-a]quinoxaline guided by primary amine

A technology of fluorophenyl and quinoxaline, which is applied in the field of primary amine-directed construction of 6-indolo[1,2-a]quinoxaline, can solve the problems of difficult preparation of substrates and high reaction temperature, and achieves operation Simple, high-yield, and step-economy results

Inactive Publication Date: 2019-04-05
GUILIN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

And in these known reactions, there are deficiencies such as reaction temperature is high, substrate is difficult to prepare, etc.

Method used

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  • Method for constructing 6-(3-fluorophenyl)indolo[1,2-a]quinoxaline guided by primary amine
  • Method for constructing 6-(3-fluorophenyl)indolo[1,2-a]quinoxaline guided by primary amine
  • Method for constructing 6-(3-fluorophenyl)indolo[1,2-a]quinoxaline guided by primary amine

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] 0.2 mmol of 2-(1H-indol-1-yl)aniline, 0.01 mmol of palladium chloride, 0.4 mmol of potassium persulfate and 0.4 mmol of 3-fluorobenzoylformic acid were successively added into the reaction tube. Then add 2 ml of 1,4-dioxane as a solvent, stir the reaction at 78°C for 12 hours, then stop the reaction, cool to room temperature and filter, and extract the filtrate three times with ethyl acetate, combine the organic phases and use 0.5 g Dried over anhydrous magnesium sulfate, filtered, and rotary evaporated under reduced pressure to obtain a crude product, which was finally separated and purified by column chromatography, and the column chromatography eluent used was a mixed solvent of petroleum ether:ethyl acetate with a volume ratio of 55:1. Pure 6-(3-fluorophenyl)indolo[1,2-a]quinoxaline was obtained with a yield of 65%.

Embodiment 2

[0022] 0.2 mmol of 2-(1H-indol-1-yl)aniline, 0.01 mmol of palladium acetate, 0.4 mmol of potassium persulfate and 0.4 mmol of 3-fluorobenzoylformic acid were successively added into the reaction tube. Then add 2 ml of 1,4-dioxane as a solvent, stir the reaction at 78°C for 12 hours, stop the reaction, cool to room temperature and filter, and extract the filtrate three times with ethyl acetate, combine the organic phases and use 0.5 g Dry over anhydrous magnesium sulfate, filter, and rotary evaporate under reduced pressure to obtain a crude product, which is finally separated and purified by column chromatography, and the eluent used in column chromatography is a mixed solvent of petroleum ether:ethyl acetate with a volume ratio of 55:1. Pure 6-(3-fluorophenyl)indolo[1,2-a]quinoxaline was obtained with a yield of 69%.

Embodiment 3

[0024] 0.2 mmol of 2-(1H-indol-1-yl)aniline, 0.01 mmol of palladium trifluoroacetate, 0.4 mmol of potassium persulfate and 0.4 mmol of 3-fluorobenzoylformic acid were successively added to the reaction tube. Then add 2 ml of 1,4-dioxane as a solvent, stir the reaction at 78°C for 12 hours, stop the reaction, cool to room temperature and filter, and extract the filtrate three times with ethyl acetate, combine the organic phases and use 0.5 g Dry over anhydrous magnesium sulfate, filter, and rotary evaporate under reduced pressure to obtain a crude product, which is finally separated and purified by column chromatography, and the eluent used in column chromatography is a mixed solvent of petroleum ether:ethyl acetate with a volume ratio of 55:1. Pure 6-(3-fluorophenyl)indolo[1,2-a]quinoxaline was obtained with a yield of 43%.

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Abstract

The invention relates to a method for constructing 6-(3-fluorophenyl)indolo[1,2-a]quinoxaline guided by primary amine. The method comprises the following steps: adding 2-(1H-indole-1-base)aniline and3-fluorobenzoylformic acid as raw materials in a reaction test tube to prepare 6-(3-fluorophenyl)indolo[1,2-a]quinoxaline by virtue of acylation / cyclization reaction. According to the invention, the primary amine is used as a traceless guiding group, so that the step economical performance of the reaction is improved; and moreover, the raw materials required for the reaction are cheap and easily available, the conditions are mild, the operation is simple, the selectivity is single, the separation yield is high, the industrial production is facilitated, and the development requirement of greenorganic chemistry can be met.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical chemical synthesis, in particular to a method for constructing 6-(3-fluorophenyl)indolo[1,2-a]quinoxaline guided by a primary amine. Background technique [0002] In recent years, organometallic chemistry has achieved unprecedented development and has become an important means of constructing carbon-carbon bonds and carbon-heterobonds. Directing group-assisted C–H functionalization reactions have attracted extensive attention from scientists due to their good selectivity and reactivity. After decades of development, a series of nitrogen-containing directing groups have been successfully used in C-H functionalization reactions, including primary amines, pyridines, amides, imines, oximes, enamines and various nitrogen-containing heterocycles. It is worth noting that there are very few reports on the C-H functionalization reaction of primary amines as directing groups, because primary amines ...

Claims

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Application Information

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IPC IPC(8): C07D487/04
CPCC07D487/04
Inventor 蒋光彬王守才及方华
Owner GUILIN UNIVERSITY OF TECHNOLOGY
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