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36results about How to "Highly economical steps" patented technology

Fluoroalkyl substituted furyl diphosphine oxide compound and preparation method thereof

The invention discloses a fluoroalkyl substituted furyl diphosphine oxide compound and a preparation method thereof. The preparation method comprises the following steps: adding an alkali accelerant and a solvent into a reaction raw material formed by mixing a polyfluoroalkyl substituted peroxide compound and an organic phosphine oxide compound, carrying out stirring and reacting for 1-24 hours inan air atmosphere at 50-90 DEG C, and determining a reaction process by using TLC detection, wherein a reaction product is obtained after the reaction is finished, a molar volume ratio of the polyfluoroalkyl substituted peroxide compound to the organic phosphine oxide compound to the alkali accelerant to the solvent is 1 mmol: (1-3) mmol: (2-6) mmol: (1-3) mL, and the solvent comprises dimethyl sulfoxide and N,N-dimethyl formamide; and washing, extracting and drying the reaction product, and carrying out column chromatography separation to obtain the fluoroalkyl substituted furyl diphosphineoxide compound. According to the method disclosed by the invention, required initial raw materials are simple, wide in source and easy to prepare, and the obtained diphosphine oxide compound has a wide application prospects in the fields of drug synthesis and material research and in related extension fields.
Owner:NANJING UNIV OF TECH

Polyfluoroalkenyl substituted oxazole compound and preparation method thereof

InactiveCN111747904AEfficient formationDiverse functional group toleranceOrganic chemistryPtru catalystNatural product
The invention discloses a polyfluoroalkenyl substituted oxazole compound and a preparation method thereof. The preparation method comprises the following steps: adding a reaction raw material formed by mixing an N-acyl enamine compound and a perfluoroalkyl iodide into an alkali accelerant and a solvent, stirring and reacting for 1-24 hours in an air atmosphere at room temperature, determining a reaction process by TLC detection, obtaining a reaction solution after the reaction is finished, finally, sequentially washing, extracting and drying the reaction solution, and carrying out column chromatography separation to obtain the polyfluoroalkenyl substituted oxazole compound. According to the preparation method, the required raw materials are simple and easy to obtain, various functional group tolerance and substrate ranges are achieved, and natural products and pharmaceutical active molecular skeletons can be introduced, the preparation method disclosed by the invention is mild in reaction condition, does not need an expensive transition metal catalyst, and meets the requirements of green and economic chemistry, and according to the preparation method, a five-membered oxazole heterocyclic ring does not need to be constructed and synthesized in advance, and the highest step economy is achieved.
Owner:NANJING UNIV OF TECH

Method for constructing 2-fluorine-6-phenyl indolo[1,2-a] quinoxaline through primary amine guiding

The invention discloses a method for constructing 2-fluorine-6-phenyl indolo[1,2-a] quinoxaline through primary amine guiding. The method comprises the following steps: adding 4-fluorine-2-(1H-indole-1-yl)phenylamine and benzoyl formic acid as the raw material in a reaction test tube, and preparing 2-fluorine-6-phenyl indolo[1,2-a] quinoxaline in high yield through acylation / cyclization reaction.The primary amine is used as a traceless guide base, and the step economy of the reaction is increased; the raw material required by the reaction is cheap and easy to obtain, the condition is mild andthe operation is simple, the selectivity is single, the separation efficiency is high, and the method is in favor of industrial production and conforms to the development demand of the green organicchemistry.
Owner:GUILIN UNIVERSITY OF TECHNOLOGY

Method for constructing 6-(3-fluorophenyl)indolo[1,2-a]quinoxaline guided by primary amine

The invention relates to a method for constructing 6-(3-fluorophenyl)indolo[1,2-a]quinoxaline guided by primary amine. The method comprises the following steps: adding 2-(1H-indole-1-base)aniline and3-fluorobenzoylformic acid as raw materials in a reaction test tube to prepare 6-(3-fluorophenyl)indolo[1,2-a]quinoxaline by virtue of acylation / cyclization reaction. According to the invention, the primary amine is used as a traceless guiding group, so that the step economical performance of the reaction is improved; and moreover, the raw materials required for the reaction are cheap and easily available, the conditions are mild, the operation is simple, the selectivity is single, the separation yield is high, the industrial production is facilitated, and the development requirement of greenorganic chemistry can be met.
Owner:GUILIN UNIVERSITY OF TECHNOLOGY

Fluoroalkyl substituted furyl monophosphine oxide compound and preparation method thereof

The invention discloses a fluoroalkyl substituted furyl monophosphine oxide compound and a preparation method thereof. The preparation method comprises the following steps: adding an alkali promoter and a solvent into a reaction raw material formed by mixing a polyfluoroalkyl substituted peroxide compound and an organic phosphine oxide compound, stirring and reacting for 1-24 h in an air atmosphere at room temperature, determining a reaction process by TLC detection, and obtaining a reaction product after the reaction is finished, wherein the molar volume ratio of the polyfluoroalkyl substituted peroxide compound to the organic phosphine oxide compound to the alkali promoter to the solvent is 1 mmol: (1-3) mmol: (2-6) mmol: (1-3) mL, and the solvent comprises chloroform, tert-butyl alcohol, acetonitrile and dichloromethane; and washing, extracting and drying the reaction product, and carrying out column chromatography separation to obtain the fluoroalkyl substituted furyl monophosphineoxide compound. The method disclosed by the invention is simple in required initial raw materials, wide in source and easy to prepare, and the obtained monophosphine oxide compound has a wide application prospect in the fields of drug synthesis, material research and related extension.
Owner:NANJING UNIV OF TECH
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