Flexible multi-lead cap-type brain magnetic instrument and high-precision imaging method thereof

Abstract

The invention discloses a flexible multi-lead cap-type brain magnetic instrument and a high-precision imaging method thereof. The brain magnetic instrument comprises a flexible multi-lead cap, a magnetic sensor array, a magnetic shielding and compensation module, a magnetic sensor position and posture calibration module, a signal detection and storage module and a brain magnetic imaging module. According to the flexible multi-lead cap-type brain magnetic instrument, by introducing the magnetic sensor position and posture calibration module, the center positions of a magnetic sensor and a standard point can be determined, the posture of the magnetic sensor relative to the tested head can be determined, and the imaging precision can be improved. According to the MEG imaging method based on CT and multi-mode MRI, multi-mode MRI at least comprises T1, T2 and DT1, and the problem of low precision of brain magnetic imaging of infants can be solved. The flexible multi-lead cap-type brain magnetic instrument is flexible to use, comfortable to wear and low in production cost; the imaging method of the instrument is easy to operate and high in imaging precision.

Description

technical field [0001] The invention relates to the field of magnetoencephalometers, in particular to a flexible multi-lead cap-type magnetoencephalometer and a high-precision imaging method thereof. Background technique [0002] The magnetoencephalometer (MEG) uses sophisticated electronic instruments such as high-sensitivity magnetic sensors to measure and record the extremely weak magnetic field information generated by the intracranial cortical neural activity outside the subject's head, and is established by signal processing and other methods. The correlation between the above-mentioned magnetic field information and neural activity (magnetic brain signal imaging), and then assisting the research of scientific issues such as diseases / brain cognition. Compared with brain signal acquisition instruments such as MRI, MEG signal time resolution is higher, about 1ms, which is more suitable for capturing and analyzing rapidly changing neural activities. Compared with EEG, ME...

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Problems solved by technology

However, the materials used in these two magnetic brain caps are traditional silicone / elastic cloth, which is not suitable for long-term wearing because of their poor skin-friendliness. Moreover, flexible wearing will cause unpredictable changes in the position of the magnetic sensor and the posture of the head relative to the subject. , although the use of the eye magnetic field measurement magnetic sensor to calibrate the position of all magnetic sensors is added to the Shanghai magnetoencephalometer, but this method cannot realize the measurement of the attitude of the magnetic sensor. It is also impossible to measure the initial posture of the device, and to a certain extent increases the weight of the headset

To sum up, the existing flexible brain magnetometers cannot realize the initial attitude measurement of the magnetic sensor relative to the subject's head, which will directly reduce the imaging accuracy and affect the follow-up clinical / scientific research.

[0006] In addition, all magnetoencephalometers have not yet been applied to infants, and almost all magnetoencephalography algorithms are designed for adults or older children. Directly applying the above algorithms to infants will cause problems due to the differences in brain tissue and brain structure of infants. Larger imaging errors due to the particularity of the disease affect research on clinical / scientific issues related to infants and young children

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