Application of 3-hydroxybutyrate and derivatives thereof in preparation of products for preventing and treating obesity obesity-related diseases
A technology of hydroxybutyric acid and its derivatives, applied in the field of medicine, can solve the problems of small side effects, treatment and prevention of obesity and related diseases, local or systemic drug allergy, calculation errors, etc., and achieve high safety, small side effects, and small doses Effect
Pending Publication Date: 2019-05-03
TSINGHUA UNIV
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Problems solved by technology
For patients, the use of exogenous insulin is an expensive and painful method, and it also brings many complications to the patient
Insulin response (hypoglycemia) due to miscalculation of insulin doses, for example, due to missing meals or erratic exercise
In addition, local or systemic allergy or immune resistance to the drug may occur with the use of the drug
[0007] At present, there is no effective method and drug for the treatment and prevention of obesity and its related diseases with little side effects in this field, so there is an urgent need to develop a new, non-toxic and side effect-resistant method for even in high-fat diets. Drugs for the treatment and prevention of obesity and its related diseases
Method used
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[0034] Experimental Materials
[0035]Mice: apoe knockout mice were purchased from the Experimental Animal Center of Peking University Health Science Center. They were normally bred mice, 5 weeks old, with a total of 40 mice. The mice were grown in the same environment and fed the same food.
[0036] High-fat food: containing 40% fat, 1.25% cholesterol, and 0.5% bile acid, purchased from Changzhou Shuyishuer Biotechnology Co., Ltd.
[0037] The repurchased mice were placed in the same environment, fed with a high-fat diet for 1 week, then fed for 9 weeks, and 200 mg / kg, 100 mg / kg, 50 mg / kg of sodium salt of 3-hydroxybutyrate were administered orally once a day, and regularly The body weight and physical condition of the mice were monitored, and the food intake of the mice was recorded every day. Sodium 3-hydroxybutyrate was intragastrically administered once a day, and sodium 3-hydroxybutyrate could significantly reduce the body weight of apoe knockout mice fed a high-fat die...
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The invention belongs to the field of medicines, and particularly relates to application of 3-hydroxybutyrate and derivatives thereof in preparation of products for preventing and treating obesity obesity-related diseases, including application of medicines, drinks, foods, or animal feed compositions and the like. 3-hydroxybutyrate and derivatives thereof can be easily absorbed by human bodies, have high safe dosage and no toxic or side effect, and are suitable for long-time administration. Experimental results further indicate that the 3-hydroxybutyrate and derivatives thereof can be used forreducing the weight of an apoe gene knockout mouse under the situation of high fat diet.
Description
technical field [0001] The invention belongs to the field of medicine, and specifically relates to the application of 3-hydroxybutyric acid and its derivatives in the preparation of products for preventing and treating obesity and obesity-related diseases. Background technique [0002] Obesity is a chronic disease, many factors can lead to obesity, its origin has not been studied clearly. Obesity is also an inducing factor for a series of diseases, such as hypertension, diabetes, coronary heart disease, gallbladder disease, osteoarthritis, sleep apnea, respiratory disorders, uterine tumors, prostate cancer, breast cancer and colon cancer. According to reports, about 97 million Americans are currently overweight and obese, of which about 15.1 million are related to type II diabetes, and about 200,000 people die from obesity-related diseases every year. [0003] Obesity is usually excess body fat due to altered physiological or biochemical functions. Fats generally include n...
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IPC IPC(8): A23L33/10A23L2/52A23K20/105A61K31/19A61P3/04
Inventor 陈国强张书杰李子华张雨点
Owner TSINGHUA UNIV