Supercharge Your Innovation With Domain-Expert AI Agents!

Preparation method of condensed heterocyclic compound

A technology of compounds and fused heterocycles, which is applied in the field of preparation of fused heterocycles, can solve the problems of restricting the widespread use of existing methods, complex separation and purification, and cumbersome steps

Active Publication Date: 2020-04-14
SOUTH CHINA AGRI UNIV
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the existing synthetic methods, the steps are cumbersome, many reagents are used, the separation and purification are complicated, and expensive or toxic metal catalysts are required, which further limits the widespread use of the existing methods

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of condensed heterocyclic compound
  • Preparation method of condensed heterocyclic compound
  • Preparation method of condensed heterocyclic compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1: raw material A

[0048] In a 50 ml reaction flask, add 0.25 mmol 5-amino-1-(2-bromo-4-trifluoromethylphenyl)-4-trifluoromethylsulfinylpyrazole-3-carbonitrile, 0.275 mmol butane Dimethyl olefinic acid was reacted under the conditions in Table 1. After the reaction was completed, cool to room temperature, add aqueous solution and extract three times with ethyl acetate, dry over anhydrous magnesium sulfate, filter and rotary evaporate to remove the solvent, pass through the column layer Analysis, separation and purification to obtain the product, the column chromatography eluent used is petroleum ether: ethyl acetate mixed solvent with a volume ratio of 10:1-5:1.

[0049] Table 1

[0050] serial number Alkali additive solvent Reaction temperature (°C) Yield(%) Condition 1 K 2 CO 3

MeCN 80 82 Condition 2 K 2 CO 3

MeOH 80 68 Condition 3 K 2 CO 3

DMF 80 65 Condition 4 K 2 CO 3

...

Embodiment 2

[0070] Embodiment 2: insecticidal activity embodiment

[0071] (1) Insecticidal activity against 2nd instar larvae of diamondback moth

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method of a fused heterocyclic compound. The preparation method comprises taking 5-amino-1H-phenyl pyrazole substrate as a raw material A to react with a raw material B in alkali additives and solvent to obtain the fused heterocyclic compound, wherein the raw material A is shown as follows, and the raw material B is shown as follows. The preparation method ofthe fused heterocyclic compound has the advantages of simple processes, easy agent acquisition, high yield and the like and is applicable to large-scale production of fused heterocyclic compounds.

Description

technical field [0001] The invention belongs to the field of synthesis of heterocyclic compounds, in particular to a preparation method of condensed heterocyclic compounds. Background technique [0002] The inventors found that the fused heterocyclic compounds listed in CN201711069917.7 and CN201810219338.4 have high killing activity against agricultural and forestry pests and sanitary pests. However, in the existing synthetic methods, the steps are cumbersome, many reagents are used, the separation and purification are complicated, and expensive or toxic metal catalysts need to be used, which further limits the wide application of the existing methods. Therefore, it is necessary to develop a more convenient preparation method. After reviewing the literature, it was found that transition metal-catalyzed carbon-hydrogen bond activation has been extensively studied in the past ten years. Among them, the carbon-hydrogen bond activation reaction of amine-containing compounds, f...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07D487/04A01P7/04
Inventor 徐汉虹江薰垣杨帅邓成菊张志祥林菲
Owner SOUTH CHINA AGRI UNIV
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com