Supermolecular chiral porous polymer separation medium and preparation method and application thereof

A technology of porous polymer and separation medium, applied in the field of separation materials, can solve the problems of limiting the ability of chiral separation medium, wide size distribution, heterogeneous shape of materials, etc., and achieves wide applicability of the preparation method and stable physical and chemical properties. , the effect of a simple synthesis method

Active Publication Date: 2019-05-17
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for most chiral MOFs materials, their ability to be used as chiral separation media is greatly limited due to their instability in water, organic solvents, and acidic environments.
The main disadvantage of C

Method used

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  • Supermolecular chiral porous polymer separation medium and preparation method and application thereof
  • Supermolecular chiral porous polymer separation medium and preparation method and application thereof
  • Supermolecular chiral porous polymer separation medium and preparation method and application thereof

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Embodiment Construction

[0036] Below in conjunction with embodiment the present invention will be described in further detail

[0037] The invention provides a supramolecular chiral porous polymer separation medium (MP-CDPs), which has the following structural formula:

[0038]

[0039]The present invention also provides a supramolecular chiral porous polymer separation medium (MP-CDPs@SiO 2 ), its structural formula is:

[0040]

[0041] The MP-CDPs and MP-CDPs@SiO 2 For the preparation method, see figure 1 and figure 2 , figure 1 Prepare a flow chart for the MP-CDPs of the present invention; figure 2 For the present invention MP-CDPs@SiO 2 The preparation flowchart; Comprise following specific steps:

[0042] Preparation of MP-CDPs:

[0043] The first step, the synthesis of P-CDPs:

[0044] Weigh 1.0g of cyclodextrin (β-CD), 0.50g of tetrafluoroterephthalonitrile, and 1.50g of potassium carbonate into a 250mL three-neck flask, add 40mL of anhydrous tetrahydrofuran, ultrasonic for 1...

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Abstract

The invention discloses a supermolecular chiral porous polymer separation medium. A preparation method of the supermolecular chiral porous polymer separation medium comprises the following steps: in the presence of potassium carbonate, performing a reaction of cyclodextrin and a tetrafluoroterephthalonitrile monomer at a certain temperature; then introducing methyl by a post modification method toprepare a supermolecular chiral porous polymer adsorption material. According to the reaction, a supermolecular chiral porous polymer chromatographic stationary phase material is prepared by a layer-by-layer modification method. The chiral separation medium synthesized by adopting the method has the advantages of simple and convenient synthesis method, wide application range of the preparation method and the like. A cyclodextrin cavity structure in a porous polymer structure has various acting sites such as inclusion interaction, hydrogen-bond interaction and host-guest recognition. As a chiral chromatographic stationary phase and a chiral adsorbent, the supermolecular chiral porous polymer separation medium can recognize and separate certain chiral substances. The chiral separation medium has specific recognition and retaining acting force to certain polar chiral substances such as alcohols, aromatic carboxylic acids and aromatic amine.

Description

technical field [0001] The invention relates to a separation material, in particular to a porous polymer chiral separation medium with large specific surface area and stable property and structure, and also relates to a preparation method and application of the separation medium material. Background technique [0002] The separation of chiral drugs plays an extremely important role in the pharmaceutical industry, and their enantiomers often exhibit different pharmacological and toxicological properties. So far, chiral recognition and separation is still an important technical problem. Especially the separation of polar chiral compounds is one of the most challenging research. Chromatography is an attractive technique for the separation of chiral compounds. The design and synthesis of chiral materials with high surface area and multiple active sites is an important means of high performance separation. In recent years, chiral porous materials have attracted extensive atten...

Claims

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Application Information

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IPC IPC(8): C08B37/16C08G83/00B01D15/08
Inventor 李攻科陈彦龙胡玉玲卢梓程
Owner SUN YAT SEN UNIV
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