Supermolecular chiral porous polymer separation medium and preparation method and application thereof

Abstract

The invention discloses a supermolecular chiral porous polymer separation medium. A preparation method of the supermolecular chiral porous polymer separation medium comprises the following steps: in the presence of potassium carbonate, performing a reaction of cyclodextrin and a tetrafluoroterephthalonitrile monomer at a certain temperature; then introducing methyl by a post modification method toprepare a supermolecular chiral porous polymer adsorption material. According to the reaction, a supermolecular chiral porous polymer chromatographic stationary phase material is prepared by a layer-by-layer modification method. The chiral separation medium synthesized by adopting the method has the advantages of simple and convenient synthesis method, wide application range of the preparation method and the like. A cyclodextrin cavity structure in a porous polymer structure has various acting sites such as inclusion interaction, hydrogen-bond interaction and host-guest recognition. As a chiral chromatographic stationary phase and a chiral adsorbent, the supermolecular chiral porous polymer separation medium can recognize and separate certain chiral substances. The chiral separation medium has specific recognition and retaining acting force to certain polar chiral substances such as alcohols, aromatic carboxylic acids and aromatic amine.

Description

technical field [0001] The invention relates to a separation material, in particular to a porous polymer chiral separation medium with large specific surface area and stable property and structure, and also relates to a preparation method and application of the separation medium material. Background technique [0002] The separation of chiral drugs plays an extremely important role in the pharmaceutical industry, and their enantiomers often exhibit different pharmacological and toxicological properties. So far, chiral recognition and separation is still an important technical problem. Especially the separation of polar chiral compounds is one of the most challenging research. Chromatography is an attractive technique for the separation of chiral compounds. The design and synthesis of chiral materials with high surface area and multiple active sites is an important means of high performance separation. In recent years, chiral porous materials have attracted extensive atten...

AI Technical Summary

Problems solved by technology

However, for most chiral MOFs materials, their ability to be used as chiral separation media is greatly limited due to their instability in water, organic solvents, and acidic environments.

The main disadvantage of CCOFs stationary phase is the heterogeneity of the material (irregular shape, submicron size, wide size distribution)

In addition, some chiral ligands are expensive, and the synthesis of CCOFs can be extremely complex

Images