Preparation method of sodium trimetaphosphate cross-linked hyaluronic acid gel and product of preparation method

A technology for cross-linking hyaluronic acid and sodium trimetaphosphate is applied in the preparation of sodium trimetaphosphate cross-linked hyaluronic acid gel and its product field, and can solve the problems of low yield, complicated gel preparation process and sticky feeling. It can achieve the effect of simple preparation process, lower production cost, and improved skin feel.

Inactive Publication Date: 2019-05-17
BLOOMAGE BIOTECHNOLOGY CORP LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the problems of complex gel preparation process, low yield and strong sticky feeling, the invention provides a preparation method of sodium trimetaphosphate cross-linked hyaluronic acid gel and its product

Method used

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  • Preparation method of sodium trimetaphosphate cross-linked hyaluronic acid gel and product of preparation method
  • Preparation method of sodium trimetaphosphate cross-linked hyaluronic acid gel and product of preparation method
  • Preparation method of sodium trimetaphosphate cross-linked hyaluronic acid gel and product of preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Dissolve 0.5 g of sodium hydroxide in 74 g of purified water, then add 6.0 g of sodium trimetaphosphate, dissolve under stirring, then add 20 g of hyaluronic acid (HA) (molecular weight: 1.48 million Daltons) under stirring, and disperse Evenly, place it in a water bath at 25°C to react for 4 hours. After the reaction is over, cut the gel into 0.1 cm small pieces, soak in 0.1 mol / L 900 mL hydrochloric acid solution, stir intermittently, swell until the volume remains constant, and wash with purified water 3 times, the dynamic viscosity is 2.25×10 5 mPa·s particle-free gel.

Embodiment 2

[0027] Dissolve 0.25 g of sodium hydroxide in 74 g of purified water, then add 6.0 g of sodium trimetaphosphate, dissolve under stirring, then add 20 g of HA (molecular weight is 700,000 Daltons) under stirring, disperse evenly, and place React in a water bath at 25°C for 18 h. After the reaction is over, cut the gel block into 0.1 cm small pieces, soak in 0.05 mol / L 900 mL hydrochloric acid solution, stir intermittently, swell until the volume remains constant, and wash 3 times with purified water , to obtain a dynamic viscosity of 1.50×10 5 mPa·s particle-free gel.

Embodiment 3

[0029] Dissolve 0.5 g sodium hydroxide in 74 g purified water, then add 3.0 g sodium trimetaphosphate, dissolve under stirring, then add 20 g HA (molecular weight is 1.77 million Daltons) under stirring, disperse evenly, place in React in a water bath at 25°C for 18 h. After the reaction is over, cut the gel block into 0.1 cm pieces, soak in 0.1 mol / L 900 mL hydrochloric acid solution, stir intermittently, swell until the volume remains constant, and wash twice with purified water , to obtain a dynamic viscosity of 2.34×10 5 mPa·s particle-free gel.

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Abstract

The invention belongs to the technical field of hyaluronic acid, and particularly relates to a preparation method and product of cross-linked hyaluronic acid gel. The hyaluronic acid is cross-linked by cross-linking agent sodium trimetaphosphate in an alkaline solution, and then the gel is cut into small pieces and immersed in the acid solution to swell, and when the volume remained the same, thehyaluronic acid cross-linked hydrogel which is colorless to light yellow, transparent and granuleless is obtained. The cross-linked gel is simple in preparation process, low in production cost, high in yield and convenient in enlargement production, and the gel has good moisturizing property and silky feeling, is not sticky, and can be used in cosmetics and medical fields.

Description

Background technique [0001] Hyaluronic acid (HA) is an acidic macromolecular mucopolysaccharide composed of N D-glucuronic acid and N-acetylglucosamine disaccharide units, also known as hyaluronic acid (Hyaluronan), sodium hyaluronate. Since hyaluronic acid molecules can carry more than 500 times of water, it is recognized as the best natural moisturizing ingredient today and is widely used in skin care products and cosmetics. However, when high-molecular-weight hyaluronic acid is used in cosmetics, it is prone to stringiness and mud formation during application. When sweating or in a relatively humid environment, the skin is prone to stickiness and poor skin feel. Cross-linked or modified hyaluronic acid has different rheological properties on the basis of retaining the original good biocompatibility and moisturizing effects of natural hyaluronic acid, which may improve its use in the field of cosmetics, such as improving skin Sensitive, anti-wrinkle, anti-aging. [0002] A...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08L5/08
Inventor 李霞魏健郭学平王玉玲石艳丽郭文逸耿凤
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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