High-flux sequencing data analysis method and device

A technology for sequencing data and analysis methods, applied in the field of biological information, can solve problems such as inability to accurately analyze variation information, and achieve the effects of fast mutation detection, improved accuracy, and improved analysis speed

Active Publication Date: 2019-05-17
3D BIOMEDICINE SCI & TECH CO LTD
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  • Abstract
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  • Claims
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Problems solved by technology

[0004] In view of the defect that existing high-throughput sequencing data analysis methods such as somatic cell variation sequencing data analysis methods cannot accurately analyze variation information, the present invention provides a high-throughput sequencing data analysis method and device

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  • High-flux sequencing data analysis method and device
  • High-flux sequencing data analysis method and device

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Embodiment Construction

[0058] In order to make the description of the present invention easier to understand, the technical terms used in the specific embodiments are firstly explained below.

[0059]

[0060]

[0061] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments.

[0062] The present invention is applied to electronic devices with display screens and input devices (such as various medical testing devices). The electronic device runs a tumor sample capture sequencing information analysis system (hereinafter also referred to as the "system"), and the specific method flow is shown in Figure 1 to Figure 1. Figure 5 description of.

[0063] In some embodiments, the information analysis process of the present invention may include:

[0064] 1) Remove joint contamination and low-quality data;

[0065] 2) Comparison, stat...

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Abstract

The invention relates to a high-flux sequencing data analysis method and a device. The high-flux sequencing data analysis method comprises the steps of acquiring high-flux sequencing data of a sampleand a reference genome sequence, comparing the high-flux sequencing data with the reference genome sequence, and respectively acquiring locus data of single nucleotide variation (SNV) and locus data of insertion deletion mutation (Indel), and respectively filtering noise points of the SNV data and the Indel data through comparing the difference substantial degrees of the variation and the background, thereby obtaining the variation data. The invention further provides a device for analyzing the high-flux sequencing data and a computer-readable storage medium for storing instructions.

Description

technical field [0001] The invention belongs to the technical field of biological information, and in particular relates to a high-throughput sequencing data analysis method and device. Background technique [0002] High-throughput sequencing technology, also known as Next Generation Sequencing (NGS for short), can sequence hundreds of thousands to tens of millions of molecules in the cell genome in parallel at one time, so it has been widely used in genome research. application. High-throughput sequencing can quickly sequence a large number of sequences, and can be used to detect gene mutations in different individuals, such as tumor patients, and provide useful suggestions and guidance for individualized treatment. However, a large amount of initial data obtained by high-throughput sequencing often includes low-quality sequences such as experimental operations, which seriously affects the analysis of sequencing data and may lead to erroneous analysis conclusions. [0003...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B20/20G16B30/00
Inventor 曹鑫恺董华李福根
Owner 3D BIOMEDICINE SCI & TECH CO LTD
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