Natural biomaterial for near infrared light excitation response and preparation method and application thereof

A technology of near-infrared light and biomaterials, which can be applied to medical preparations containing active ingredients, wave energy or particle radiation treatment materials, drug combinations, etc., and can solve problems such as research on the photothermal properties of natural biomaterials

Active Publication Date: 2019-05-21
WENZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nanoparticles of photothermal materials mainly include metal nanoparticles, organic nanoparticles, and inorganic nanoparticles, but there is no specific literature or monograph on the photothermal properties of natural biological materials.

Method used

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  • Natural biomaterial for near infrared light excitation response and preparation method and application thereof
  • Natural biomaterial for near infrared light excitation response and preparation method and application thereof
  • Natural biomaterial for near infrared light excitation response and preparation method and application thereof

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preparation example Construction

[0035] This embodiment provides a kind of natural biological material used for near-infrared light excitation response, and its preparation method includes the following steps:

[0036] S100, degreasing the natural pollen.

[0037] Degreasing the natural pollen in the first solvent, removing the solvent containing the ester after degreasing, washing with the first solvent and drying.

[0038] Wherein, the natural pollen includes any one or a mixture of natural sunflower pollen, dandelion pollen, wolfberry pollen, rape flower pollen and natural pine pollen. The dosage ratio of natural pollen to the first solvent is 1g:10-15ml; too much solution will increase the dosage of solvent and increase the cost of the experiment, and too little solvent will result in insufficient degreasing. Preferably, the first solvent includes one or a mixture of diethyl ether, ethyl acetate, and acetone.

[0039] In this embodiment, the first solvent is used for washing several times, for example, ...

Embodiment 1

[0054] Take 20g of dried natural sunflower pollen in a round bottom flask, add 200ml of ether, stir overnight at room temperature under a relative centrifugal force of 600g, remove ether by suction filtration, wash with ether three times, dry at 60°C to obtain defatted natural sunflower pollen, and store at room temperature .

Embodiment 2

[0056] Take 20g of dried natural sunflower pollen in a round bottom flask, add 250ml of ether, stir overnight at room temperature under a relative centrifugal force of 600g, remove ether by suction filtration, wash with ether three times, dry at 60°C to obtain defatted natural sunflower pollen, and store at room temperature .

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Abstract

The invention relates to the field of photothermal materials, and provides a natural biological material for a near infrared light excitation response and a preparation method and application thereof.The preparation method comprises the steps that natural pollen is degreased in a first solvent, the solvent into which ester is dissolved is removed after degreasing, washing is conducted with the first solvent, and then drying is conducted. The obtained natural biomaterial for the near infrared light excitation response is a pure natural biomaterial; in addition, the material can be heated repeatedly for multiple times under near infrared light irradiation, and the biomaterial has the good heating performance. At present, few people propose the idea of using the natural biomaterial as a photothermal treatment material, the natural pollen is processed to form degreased natural pollen to serve as the photothermal treatment material, and the new photothermal treatment material is provided.

Description

technical field [0001] The invention relates to the field of photothermal materials, in particular, to a natural biological material used for near-infrared light excitation response, its preparation method and application. Background technique [0002] Tumor is a disease that mainly threatens human life and health. Traditional tumor treatment methods include tumor resection, biological therapy, traditional Chinese medicine treatment, chemical drug therapy, and radiation therapy. However, each treatment method has some limitations. With the continuous progress of social science, the rapid development of laser and near-infrared technology, the rapid development of research on the method of treating tumors through nanomedicine. As a minimally invasive tumor treatment technology, photothermal therapy has high specificity, can target tumors, and has good biocompatibility. It can use near-infrared excitation light as a light source to excite nanoparticles and convert the light sou...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61P35/00
Inventor 何华成吴疆杨耀李圣宇陈艳欣叶梦琦
Owner WENZHOU UNIVERSITY
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