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Two-component composition

A composition and two-component technology, applied in the field of drug two-component composition, treatment and prevention of emergency myocardial infarction, can solve the problems of dissolution and release of saliva production obstruction, incompetence, etc.

Pending Publication Date: 2019-05-21
阿萨德股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, dissolution and release of ASA from chewable tablets is also often hampered by reduced or insufficient saliva production in patients for the same reasons as above
[0018] In general, even though ASA-containing products are available for emergency applications (see e.g. http: / / dummypage2.tripod.com / indx.htm#origin), such products are ineffective in cases of lack of water or insufficient saliva production The next will also be incompetent

Method used

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  • Two-component composition
  • Two-component composition
  • Two-component composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0118] Example 1: Preparation of a two-component composition, dissolving ASA in water together with citric acid and preservatives

[0119] The following aqueous solutions (test solutions) were prepared by dissolving and mixing citric acid and preservatives in water. The amounts of the ingredients are listed in Table 1.

[0120] Table 1

[0121] test solution

A

B

C

D

Methylparaben

0.1g

0.1g

0.1g

0

Sodium citrate

1.0g

3.0g

5.0g

3.0g

Purified water added

100ml

100ml

100ml

100ml

[0122] Sample D was included to test the effect of the presence of preservative on the dissolution of ASA, and to evaluate whether the presence of preservative resulted in undesired foaming.

[0123] For the purpose of testing the dissolution properties of the test solutions, a device as disclosed in WO 98 / 38104 was used provided by Bormioli Rocco S.p.A., Italy.

[0124] 8, 10, 12 and 14 ml of test solutions A-D were r...

Embodiment 2

[0135] Example 2: Preparation of a two-component composition, dissolving ASA in water together with trisodium citrate and carbonate

[0136] The following aqueous solutions (test solutions) were prepared by dissolving and mixing sodium citrate dihydrate (trisodium citrate) and anhydrous sodium carbonate in water. The amounts of ingredients are listed in Table 2.

[0137] Table 2

[0138] test solution

E

Sodium citrate dihydrate

150g

Anhydrous Sodium Carbonate

10g

Pure water added

1000ml

[0139] Test solution E was tested as described in Example 1 using the apparatus used in Example 1 (disclosed in WO98 / 38104 supplied by Bormioli Rocco S.p.A., Italy).

[0140] 15 ml of test solution E was filled into the container (bottle) of the test device (triple-phase kit with PET bottle, Bormioli Rocco S.p.A., Italy).

[0141] The pH of the aqueous sodium citrate dihydrate and carbonate solution was about 11.5. Therefore, no preservativ...

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Abstract

The present invention relates to a novel two-component composition comprising acetylsalicylic acid (ASA) and which is particularly useful in providing an aqueous solution of ASA for immediate peroraladministration.

Description

technical field [0001] The present invention relates to a new two-component composition for the treatment and prevention of acute myocardial infarction. Specifically, the present invention relates to a pharmaceutical two-component composition comprising a first component and a second component, wherein the first component comprises acetylsalicylic acid (ASA), and the second component comprises an aqueous solution comprising an organic salt of acid. The two-component composition enables immediate dissolution of ASA when the first and second components of the two-component composition of the present invention are mixed, and is particularly useful in the treatment of acute myocardial infarction. In order to avoid the development of a heart attack, or to reduce the extent of the damage of a heart attack, the two-component composition of the present invention is used in particular as an emergency treatment for patients requiring immediate administration of ASA. Background techni...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/616A61K47/12A61J3/07A61K9/48B65D81/32B65D51/28A61P9/10A61J1/20
CPCA61K9/4808A61K9/4858A61K9/485A61K31/616A61P9/10A61J1/2093A61J3/072A61J3/074A61K9/0095A61K47/12A61K31/216A61K47/186A61K33/00A61K9/0053A61K9/08A61K47/14
Inventor 约翰·比约恩·弗雷德里克松
Owner 阿萨德股份有限公司